POM-V Prescription Required

Rifen 100 mg/ml Solution for Injection for Horses, Cattle and Pigs

Active ingredient: Ketoprofen

Form

Injection

Species

Cattle Horses Pigs

Manufacturer

VetViva Richter GmbH

VMD MA No.

57446/3000

What it's used for

Cattle Diseases associated with inflammation, pain or fever: - - - and to ease uprise post parturition - For the relief of post-operative pain associated w...

Full indications, dosage and side effects ↓

View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for Ketoprofen

1

Ask your vet for a written prescription

They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

Fill it at a registered online retailer

The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Your prescription rights → VMD register of retailers →

Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Rifen 100 mg/ml Solution for Injection for Horses, Cattle and Pigs — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

Cattle
Diseases associated with inflammation, pain or fever:
-
-
-
and to ease uprise post parturition
-
For the relief of post-operative pain associated with dehorning in calves.
Pigs
Diseases associated with inflammation, pain or fever:
-
Metritis Agalactia (MMA) Syndrome
-
-
For the short-term relief of post-operative pain associated with minor soft tissue
surgery such as castration in piglets.
Where necessary ketoprofen should be combined with appropriate antimicrobial
therapy.

Cattle: Intravenous or intramuscular use (i.v. or i.m.)
Pigs: Intramuscular use (i.m.)
To ensure a correct dosage, body weight should be determined as accurately as
possible.
Horses:
2.2 mg ketoprofen/kg body weight/day intravenously once daily for up to 3 to 5
consecutive days, i.e. 1 ml per 45 kg body weight.
In order to treat colic one injection is normally sufficient. A second administration of
ketoprofen requires a reassessment of the patient’s clinical status. See section 3.5
Special precautions for use.
Cattle:
3 mg ketoprofen/kg body weight/day intravenously or deep intramuscularly once daily
for up to 3 consecutive days, i.e. 3 ml per 100 kg body weight.
For the relief of post-operative pain associated with dehorning the veterinary
medicinal product should be administered as a single injection intravenously or deep
intramuscularly 10 – 30 minutes before the procedure.
In cattle, the volume per injection site for i.m. injection should not exceed 9 ml. If the
injection volume exceeds 9 ml, this volume should be divided into multiple doses,
administered at different injection sites.
Pigs:
3 mg ketoprofen/kg body weight as a single deep intramuscular injection, i.e. 3 ml per
100 kg body weight (= 0.03 ml/kg).
For reduction of post-operative pain the veterinary medicinal product should be
injected 10 - 30 minutes before surgical intervention. Particular care should be taken
with regard to the accuracy of dosing including the use of an appropriate dosing
device (i.e.: low dose syringe).

Do not use in cases of hypersensitivity to the active substance, or to any of the
excipients.
Do not use in animals suffering from gastrointestinal lesions, haemorrhagic diathesis,
impaired hepatic, renal or cardiac function.
Do not use with other NSAID drugs concurrently or within 24 hours of each other.

Horses, cattle, pigs:
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Hypersensitivity reaction, Anaphylaxis
.Undetermined frequency
(cannot be estimated from the
available data):
Gastrointestinal irritation
, Gastric ulceration
,
Small intestine ulcer
;
Renal disorder
;
Injection site irritation
;
Inappetence
.
Anaphylaxis may be life-threatening and should be treated symptomatically.
Due to the mechanism of action of NSAIDs (inhibition of prostaglandin synthesis).
Transient, caused by intramuscular injections.
Only in pigs, due to repeated administration, reversible.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.

Treatment of piglets with ketoprofen before castration reduces post-operative pain for
1 hour. To obtain pain relief during surgery co-medication with an appropriate
anaesthetic/sedative is needed.
Treatment of calves with ketoprofen before dehorning reduces post-operative pain.
Ketoprofen alone will not provide adequate pain relief during the dehorning
procedure. To obtain pain relief during dehorning co-medication with an appropriate
local anaesthetic is needed.

Special precautions for safe use in the target species:
Avoid intra-arterial injection. Do not exceed recommended dose or period of
treatment. Special care should be taken when administering the veterinary medicinal
product to animals with severe dehydration, hypovolaemia and hypotension as there
is a potential risk of increased renal toxicity.
The use of ketoprofen is not recommended in foals under the age of 15 days. Use in
animals less than 6 weeks of age or in aged animals may involve additional risk. If
such use cannot be avoided, animals may require a reduced dosage and careful
management. See section 3.7 regarding the use of the veterinary medicinal product
in pregnant mares and sows.
Sufficient drinking water must be supplied at all times during treatment.
In colic, a subsequent dose may be given only after a thorough re-examination.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
In case of accidental self-injection, seek medical advice immediately and show the
package leaflet or the label to the physician. People with known hypersensitivity to
ketoprofen or benzyl alcohol should avoid contact with the veterinary medicinal
product.
Avoid splashes on the skin and eyes. Rinse thoroughly with water should this occur.
If irritation persists seek medical advice. Wash hands after use.
Special precautions for the protection of the environment:
Not applicable.

The veterinary medicinal product must not be administered in conjunction with, or
within 24 hours of administration of other NSAIDs and glucocorticoids. Concurrent
administration of diuretics, nephrotoxic drugs and anticoagulative drugs should be
avoided.
Ketoprofen is highly bound to plasma proteins, and may displace or be displaced by
other highly protein bound medicines, such as anticoagulants with the possibility of
consequent toxic effects due to the unbound fraction of the drug. Due to the fact that
ketoprofen may inhibit platelet aggregation and cause gastrointestinal ulceration, it
should not be used with other medicines that have the same profile of adverse drug
reactions.

Keep the glass vial in the outer carton in order to protect from light.
After first opening the immediate packaging do not store above 25 °C.

Meat and offal:
Horses:1 day (24 hours)
Cattle: i.v. 1 day (24 hours)
i.m. 3 days (72 hours)
Pigs: 4 days
Milk (cattle): Zero hours
Not authorised for use in mares producing milk for human consumption.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.