POM-V Prescription Required

Dinalgen 150 mg/ml Solution for Injection for Cattle, Pigs and Horses

Active ingredient: Ketoprofen

Form

Injection

Species

Cattle Horses Pigs

Manufacturer

Ecuphar Veterinaria S.L.U.

VMD MA No.

46037/4003

What it's used for

- Reduction of fever associated with bovine respiratory disease. - Reduction of inflammation, fever and pain in acute clinical mastitis in combination with...

Full indications, dosage and side effects ↓

View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for Ketoprofen

1

Ask your vet for a written prescription

They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

Fill it at a registered online retailer

The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Your prescription rights → VMD register of retailers →

Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Dinalgen 150 mg/ml Solution for Injection for Cattle, Pigs and Horses — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

- Reduction of fever associated with bovine respiratory disease.
- Reduction of inflammation, fever and pain in acute clinical mastitis in combination with
antimicrobial therapy where appropriate.
Pigs:
- Reduction of pyrexia in cases of respiratory disease and Postpartum Dysglactia
Syndrome-PDS-(Metritis Mastitis Agalactia syndrome) in sows, in combination with
antimicrobial therapy, where appropriate.
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Horses:
- Reduction of inflammation and pain associated with osteoarticular and musculoskeletal
disorders (lameness, laminitis, osteoarthritis, synovitis, tendinitis, etc.).
- Reduction of postoperative pain and inflammation.
- Reduction of visceral pain associated with colic.

Cattle:
3 mg ketoprofen/kg body weight, i.e. 1ml of veterinary medicinal product per 50 kg body
weight/ day, administered via the intravenous or intramuscular route, preferably in the neck
region.
The duration of treatment is 1-3 days, and should be established according to the severity
and duration of symptoms.
Pigs:
3 mg of ketoprofen/kg body weight i.e. 1 ml of the veterinary medicinal product per 50 kg
body weight/ day, administered via the intramuscular route on a single occasion.
Depending on the response observed and based on the benefit-risk analysis by the
AN: 00752/2024 & 00757/2024
responsible veterinarian treatment may be repeated at intervals of 24 hours for a
maximum of three treatments. Each injection should be given at a different site.
Horses:
2.2 mg of ketoprofen/kg body weight, i.e. 0.75 ml of the veterinary medicinal product. per
50 kg body weight/ day, administered via the intravenous route.
The duration of treatment is 1-5 days, and should be established according to the severity
and duration of symptoms. In the case of colic one injection is normally sufficient. A
second administration of ketoprofen requires a clinical re-examination.

Do not use in animals where there is the possibility of gastro-intestinal ulceration or
bleeding, in order not to aggravate their situation.
Do not use in animals suffering from cardiac, hepatic, or renal disease.
Do not use in cases of hypersensitivity to the active substance or acetyl-salicylic acid or to
any of the excipients.
Do not use in animals with evidence of blood dyscrasia or coagulopathy.
Do not administer other non-steroidal anti-inflammatory drugs (NSAIDs) concurrently or
within 24 hours of each other.

Cattle:
Very rare (<1 animal / 10,000 animals
treated, including isolated reports):
Injections site necrosis
Digestive tract disorders
Renal disorder
When injected intramuscularly. Lesions are subclinical, mild and gradually resolve in
the days after completion of treatment. Administration in the neck region minimizes the
extension and severity of these lesions.
Erosive and ulcerative lesions after repeated administrations, gastric intolerance.
Pigs:
Very rare (<1 animal / 10,000 animals
treated, including isolated reports):
Injections site necrosis
Digestive tract disorders
Renal disorders
When injected intramuscularly. Lesions are subclinical, mild and gradually

resolve in
the days after completion of treatment. Administration in the neck region minimizes the
extension and severity of these lesions.
Erosive and ulcerative lesions after repeated administrations, gastric intolerance.

Horses:
Very rare (<1 animal / 10,000 animals
treated, including isolated reports):
Injection site necrosis
Injection site reactions
Digestive tract disorders
Renal disorders
When injected intramuscularly. Lesions are subclinical, mild and gradually

resolve in
the days after completion of treatment. Administration in the neck region minimizes the
extension and severity of these lesions.
Local reaction resolving after 5 days, after one administration of the veterinary
medicinal product at the recommended volume by extravascular route.
Erosive and ulcerative lesions after repeated administrations, gastric intolerance.

If side effects occur treatment must be stopped and the advice of a veterinarian should be
sought.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
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either the marketing authorisation holder or the national competent authority via the
national reporting system. See the package leaflet for respective contact details.

None.

Special precautions for safe use in the target species:
Do not exceed the recommended dose. Do not exceed the recommended treatment
period.
The use of ketoprofen is not recommended in foals less than one month of age. When
administering to animals of less than 6 weeks of age, ponies or in aged animals it is
necessary to adjust the dose accurately as well as to perform a close clinical follow-up.
Avoid intra-arterial injection.
Avoid use in any dehydrated, hypovolaemic or hypotensive animals as there is a potential
risk of increased renal toxicity.
Since gastric ulceration is a common finding in PMWS (Post-weaning Multisystemic
Wasting Syndrome), the use of ketoprofen in pigs affected by this pathology is not
recommended, in order not to aggravate their situation. In horses, avoid extravascular
administration.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
Hypersensitivity reactions (skin rash, urticaria) could occur. People with known
hypersensitivity to the active substance or to any of the excipients should avoid contact
with the veterinary medicinal product.
Avoid contact with the skin, eyes and mucous membranes.
AN: 00752/2024 & 00757/2024
In case of accidental skin, eye or mucous membrane contact, wash the affected area
thoroughly with clean running water immediately. Seek medical advice if irritation persists.
Avoid accidental self-injection. In case of accidental self-injection, seek medical advice
immediately and show the package leaflet or the label to the physician.
Wash hands after use.
Special precautions for the protection of the environment:
Not applicable.

- Concurrent administration of diuretics or potentially nephrotoxic drugs should be avoided
since there is an increase of renal disturbances, including renal failure. This is secondary
to the diminished renal blood flow caused by the inhibition of renal prostaglandins
synthesis.
- Do not administer other non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids,
anticoagulants or diuretics concurrently or within 24 hours of administration of the
veterinary medicinal product since the risk of gastrointestinal ulceration and other adverse
reactions may be exacerbated.
- The treatment free period should however take into account the pharmacological
properties of the products used previously .
- Ketoprofen is highly bound to plasma proteins and may compete with other highly bound
drugs which can lead to toxic effects.

Keep the vial in the outer carton.
This veterinary medicinal product does not require any special temperature storage
conditions.

Cattle:
Meat and offal: 2 days
Milk: zero hours
Horses:
Meat and offal: 1 day
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Milk: Not authorised for use in mares producing milk for human consumption
Pig:
Meat and offal: 3 days

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.