POM-V
Prescription Required
Companion Animal
Receptal 4 microgram/ml solution for injection
Active ingredient: Buserelin
Form
Injection
Species
Cattle
Horses
Pigs
Rabbits
Trout
Manufacturer
Intervet International B.V.
VMD MA No.
06376/4122
What it's used for
• the luteal phase following artificial insemination. Amended pages: February 2026 AN: 03634/2024 & 03636/2024 Horses (mares): • Pigs (sows, gilts): • prog...
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Clinical information
Receptal 4 microgram/ml solution for injection — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.
•
the luteal phase following artificial insemination.
Amended pages: February 2026
AN: 03634/2024 & 03636/2024
Horses (mares):
•
Pigs (sows, gilts):
•
program.
Rabbits (adult females):
•
Trout:
•
•
the luteal phase following artificial insemination.
Amended pages: February 2026
AN: 03634/2024 & 03636/2024
Horses (mares):
•
Pigs (sows, gilts):
•
program.
Rabbits (adult females):
•
Trout:
•
•
Trout: intramuscular use, 2 cm above the lateral line posterior to the dorsal fin.
The stopper may be safely punctured up to 12 times. When treating groups of animals at
the same time, use a draw-off needle that has been placed in the vial stopper to avoid
excess broaching of the stopper. The draw-off needle should be removed after treatment.
Dosage:
Cattle (cows, heifers): Depending on the indication, a single dose of 10 mcg buserelin per
animal (corresponding to 2.5 ml of the veterinary medicinal product) or 20 mcg buserelin
per animal (corresponding to 5.0 ml of the veterinary medicinal product).
Horses (mares): A single dose of 40 mcg buserelin per animal (corresponding to 10 ml of
the veterinary medicinal product).
Pigs (sows, gilts): A single dose of 10 mcg buserelin per animal (corresponding to 2.5 ml
of the veterinary medicinal product).
Rabbits (adult females): A single dose of 0.8 mcg buserelin per animal (corresponding to
0.2 ml of the veterinary medicinal product).
Trout: A single dose of 3 – 4 mcg buserelin per kg bodyweight (corresponding to 0.75 –
1.0 ml of the veterinary medicinal product).
Protocols for use:
Cattle (cows, heifers)
Treatment of infertility associated with follicular cysts:
Administer a single dose of 20 mcg buserelin per animal.
A response to treatment is expected within 10-14 days. If a palpable corpus luteum does
not develop, or a new cyst forms, the treatment should be repeated. Insemination should
be performed at the first oestrus after treatment.
Induction and synchronisation of oestrus and ovulation in combination with prostaglandin
F2α or its analogues, with or without progestogens, as part of a timed artificial
insemination protocol:
Judgement on the protocol should be chosen by the responsible veterinarian, on the basis
of the intended objective and characteristics of the individual herd or animal. The following
protocols have been evaluated and could be used:
Amended pages: February 2026
AN: 03634/2024 & 03636/2024
In cyclic cows:
Day 0: Administer a single dose of 10 mcg buserelin per animal.
Day 7: Administer prostaglandin or analogue (at luteolytic dosage).
Day 9: Administer a single dose of 10 mcg buserelin per animal.
Artificial insemination 16 to 24 hours after the second (buserelin) injection of this veterinary
medicinal product or at the time of oestrus, if earlier.
In cyclic and non-cyclic cows:
Day 0: Administer a single dose of 10 mcg buserelin per animal and insert a progestogen-
releasing insert.
Day 7: Remove the progestogen-releasing insert and administer prostaglandin or its
analogue (at luteolytic dosage).
Day 9: Administer a single dose of 10 mcg buserelin per animal.
Artificial insemination 16 to 24 hours after the second (buserelin) injection of this veterinary
medicinal product or at the time of oestrus, if earlier.
Alternatively:
Day 0: Administer a single dose of 10 mcg buserelin per animal and insert a progestogen-
releasing insert.
Day 7: Remove the progestogen-releasing insert and administer prostaglandin or its
analogue (at luteolytic dosage) and PMSG (400 – 500 IU).
Day 9: Administer a single dose of 10 mcg buserelin per animal.
Artificial insemination 16 to 24 hours after the second (buserelin) injection of this veterinary
medicinal product or at the time of oestrus, if earlier.
Improvement in conception and / or pregnancy rates in cows with low fertility, during the
luteal phase following artificial insemination:
Administer a single dose of 10 mcg buserelin per animal 11 - 13 days after insemination.
Horses (mares)
Induction of ovulation and improvement in conception and / or pregnancy rates:
Administer a single dose of 40 mcg buserelin per animal on the first day that the follicle
reaches its optimal size (as determined by previous clinical history and transrectal
examinations).
Ovulation usually occurs within 24 - 36 hours after treatment; if the mare has not ovulated
during this period, administration should be repeated.
Pigs (sows, gilts)
Induction of ovulation following oestrus synchronisation as part of an insemination program
Gilts: Administer a single dose of 10 mcg buserelin per animal between 115 - and 120 -
hours following oestrus synchronization with a progestogen. A single artificial insemination
should be performed 30 - 33 hours after administration of the veterinary medicinal product.
Sows: Administer a single dose of 10 mcg buserelin per animal 83 - 89 hours after
weaning. A single artificial insemination should be performed 30 - 33 hours after
administration of the veterinary medicinal product.
In individual cases, oestrus may not be visible 30 - 33 hours after treatment with the
veterinary medicinal product. In such cases, insemination can be carried out later, at a
time when oestrus symptoms are present.
Rabbits (adult females)
Amended pages: February 2026
AN: 03634/2024 & 03636/2024
Induction of ovulation and improvement in conception rates:
Administer a single dose of 0.8 mcg buserelin per animal at the time of mating or
insemination.
For post-partum insemination, administer a single dose of 0.8 mcg buserelin no less than
24 hours post-partum, followed immediately by insemination.
Trout
Facilitation of strip spawning and reduction of mortality after stripping:
Administer a single dose of 3-4 mcg buserelin per kg bodyweight to fish in spawning
condition. Stripping should be performed 2-3 days after treatment with the veterinary
medicinal product.
The stopper may be safely punctured up to 12 times. When treating groups of animals at
the same time, use a draw-off needle that has been placed in the vial stopper to avoid
excess broaching of the stopper. The draw-off needle should be removed after treatment.
Dosage:
Cattle (cows, heifers): Depending on the indication, a single dose of 10 mcg buserelin per
animal (corresponding to 2.5 ml of the veterinary medicinal product) or 20 mcg buserelin
per animal (corresponding to 5.0 ml of the veterinary medicinal product).
Horses (mares): A single dose of 40 mcg buserelin per animal (corresponding to 10 ml of
the veterinary medicinal product).
Pigs (sows, gilts): A single dose of 10 mcg buserelin per animal (corresponding to 2.5 ml
of the veterinary medicinal product).
Rabbits (adult females): A single dose of 0.8 mcg buserelin per animal (corresponding to
0.2 ml of the veterinary medicinal product).
Trout: A single dose of 3 – 4 mcg buserelin per kg bodyweight (corresponding to 0.75 –
1.0 ml of the veterinary medicinal product).
Protocols for use:
Cattle (cows, heifers)
Treatment of infertility associated with follicular cysts:
Administer a single dose of 20 mcg buserelin per animal.
A response to treatment is expected within 10-14 days. If a palpable corpus luteum does
not develop, or a new cyst forms, the treatment should be repeated. Insemination should
be performed at the first oestrus after treatment.
Induction and synchronisation of oestrus and ovulation in combination with prostaglandin
F2α or its analogues, with or without progestogens, as part of a timed artificial
insemination protocol:
Judgement on the protocol should be chosen by the responsible veterinarian, on the basis
of the intended objective and characteristics of the individual herd or animal. The following
protocols have been evaluated and could be used:
Amended pages: February 2026
AN: 03634/2024 & 03636/2024
In cyclic cows:
Day 0: Administer a single dose of 10 mcg buserelin per animal.
Day 7: Administer prostaglandin or analogue (at luteolytic dosage).
Day 9: Administer a single dose of 10 mcg buserelin per animal.
Artificial insemination 16 to 24 hours after the second (buserelin) injection of this veterinary
medicinal product or at the time of oestrus, if earlier.
In cyclic and non-cyclic cows:
Day 0: Administer a single dose of 10 mcg buserelin per animal and insert a progestogen-
releasing insert.
Day 7: Remove the progestogen-releasing insert and administer prostaglandin or its
analogue (at luteolytic dosage).
Day 9: Administer a single dose of 10 mcg buserelin per animal.
Artificial insemination 16 to 24 hours after the second (buserelin) injection of this veterinary
medicinal product or at the time of oestrus, if earlier.
Alternatively:
Day 0: Administer a single dose of 10 mcg buserelin per animal and insert a progestogen-
releasing insert.
Day 7: Remove the progestogen-releasing insert and administer prostaglandin or its
analogue (at luteolytic dosage) and PMSG (400 – 500 IU).
Day 9: Administer a single dose of 10 mcg buserelin per animal.
Artificial insemination 16 to 24 hours after the second (buserelin) injection of this veterinary
medicinal product or at the time of oestrus, if earlier.
Improvement in conception and / or pregnancy rates in cows with low fertility, during the
luteal phase following artificial insemination:
Administer a single dose of 10 mcg buserelin per animal 11 - 13 days after insemination.
Horses (mares)
Induction of ovulation and improvement in conception and / or pregnancy rates:
Administer a single dose of 40 mcg buserelin per animal on the first day that the follicle
reaches its optimal size (as determined by previous clinical history and transrectal
examinations).
Ovulation usually occurs within 24 - 36 hours after treatment; if the mare has not ovulated
during this period, administration should be repeated.
Pigs (sows, gilts)
Induction of ovulation following oestrus synchronisation as part of an insemination program
Gilts: Administer a single dose of 10 mcg buserelin per animal between 115 - and 120 -
hours following oestrus synchronization with a progestogen. A single artificial insemination
should be performed 30 - 33 hours after administration of the veterinary medicinal product.
Sows: Administer a single dose of 10 mcg buserelin per animal 83 - 89 hours after
weaning. A single artificial insemination should be performed 30 - 33 hours after
administration of the veterinary medicinal product.
In individual cases, oestrus may not be visible 30 - 33 hours after treatment with the
veterinary medicinal product. In such cases, insemination can be carried out later, at a
time when oestrus symptoms are present.
Rabbits (adult females)
Amended pages: February 2026
AN: 03634/2024 & 03636/2024
Induction of ovulation and improvement in conception rates:
Administer a single dose of 0.8 mcg buserelin per animal at the time of mating or
insemination.
For post-partum insemination, administer a single dose of 0.8 mcg buserelin no less than
24 hours post-partum, followed immediately by insemination.
Trout
Facilitation of strip spawning and reduction of mortality after stripping:
Administer a single dose of 3-4 mcg buserelin per kg bodyweight to fish in spawning
condition. Stripping should be performed 2-3 days after treatment with the veterinary
medicinal product.
Do not use in cases of hypersensitivity to the active substance or to any of the excipients.
Cattle (cows, heifers), horses (mares), pigs (sows, gilts), rabbits (adult females), trout:
None known.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.
None known.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.
Treatment with a GnRH analogue does not eliminate the underlying cause(s) of the fertility
disorder.
Residues of alcohol and disinfectants may affect the activity of buserelin. Therefore, care
should be taken to ensure that skin and/or stopper of the vial are completely dry after
disinfection before piercing.
Cattle (cows, heifers):
Cattle with a short interval between calving and insemination (< 60 days), low body
condition score or high parity may have a lower pregnancy rate after a standard
synchronization protocol (see section 3.9). There is no guarantee that all cows
synchronized according to protocol will be in oestrus at the time of artificial insemination.
The chances of conception may be higher if the cow is in oestrus at the time of
insemination.
Pigs (sows, gilts):
The presence of a boar at the time of artificial insemination is recommended.
Animals should be checked for signs of oestrus before insemination.
A negative energy balance during lactation may be associated with mobilization of body
reserves resulting in a sharp decrease in the thickness of the fat on the back (more than
about 30%). In these animals, oestrus and ovulation may be delayed, and these animals
should be cared for and bred on an individual basis.
Special precautions for safe use in the target species:
Infection may occur if anaerobic bacteria penetrate tissue at the injection site, in particular
following intramuscular injection. Use aseptic techniques when injecting the veterinary
medicinal product.
Amended pages: February 2026
AN: 03634/2024 & 03636/2024
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
Buserelin may affect reproductive function, as it has been shown to be foetotoxic in
laboratory animals.
Women of childbearing age should handle this veterinary medicinal product with caution.
Pregnant women should not administer this veterinary medicinal product.
When administering the veterinary medicinal product, care should be taken to avoid eye
and skin contact or accidental self-injection.
In case of accidental eye contact, rinse thoroughly with water. Should skin contact with the
veterinary medicinal product occur, wash exposed area immediately with soap and water.
In case of accidental self-injection, seek medical advice immediately and show the
package leaflet or label to the physician.
For GB:
People with known hypersensitivity to GnRH analogues or benzyl alcohol should avoid
contact with the veterinary medicinal product.
For NI:
People with known hypersensitivity to GnRH analogues and benzyl alcohol or any of the
excipients should avoid contact with the veterinary medicinal product.
Special precautions for the protection of the environment:
Not applicable.
disorder.
Residues of alcohol and disinfectants may affect the activity of buserelin. Therefore, care
should be taken to ensure that skin and/or stopper of the vial are completely dry after
disinfection before piercing.
Cattle (cows, heifers):
Cattle with a short interval between calving and insemination (< 60 days), low body
condition score or high parity may have a lower pregnancy rate after a standard
synchronization protocol (see section 3.9). There is no guarantee that all cows
synchronized according to protocol will be in oestrus at the time of artificial insemination.
The chances of conception may be higher if the cow is in oestrus at the time of
insemination.
Pigs (sows, gilts):
The presence of a boar at the time of artificial insemination is recommended.
Animals should be checked for signs of oestrus before insemination.
A negative energy balance during lactation may be associated with mobilization of body
reserves resulting in a sharp decrease in the thickness of the fat on the back (more than
about 30%). In these animals, oestrus and ovulation may be delayed, and these animals
should be cared for and bred on an individual basis.
Special precautions for safe use in the target species:
Infection may occur if anaerobic bacteria penetrate tissue at the injection site, in particular
following intramuscular injection. Use aseptic techniques when injecting the veterinary
medicinal product.
Amended pages: February 2026
AN: 03634/2024 & 03636/2024
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
Buserelin may affect reproductive function, as it has been shown to be foetotoxic in
laboratory animals.
Women of childbearing age should handle this veterinary medicinal product with caution.
Pregnant women should not administer this veterinary medicinal product.
When administering the veterinary medicinal product, care should be taken to avoid eye
and skin contact or accidental self-injection.
In case of accidental eye contact, rinse thoroughly with water. Should skin contact with the
veterinary medicinal product occur, wash exposed area immediately with soap and water.
In case of accidental self-injection, seek medical advice immediately and show the
package leaflet or label to the physician.
For GB:
People with known hypersensitivity to GnRH analogues or benzyl alcohol should avoid
contact with the veterinary medicinal product.
For NI:
People with known hypersensitivity to GnRH analogues and benzyl alcohol or any of the
excipients should avoid contact with the veterinary medicinal product.
Special precautions for the protection of the environment:
Not applicable.
None known.
Do not store above 25 °C.
Keep the vial in the outer carton in order to protect from light.
Keep the vial in the outer carton in order to protect from light.
Cattle, horses
Meat and offal: Zero days.
Milk: Zero hours.
Pigs, rabbits
Meat and offal: Zero days.
Trout
Meat and offal: Zero degree days.
Meat and offal: Zero days.
Milk: Zero hours.
Pigs, rabbits
Meat and offal: Zero days.
Trout
Meat and offal: Zero degree days.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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Same active ingredient
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