Pronestesic 40 mg/ml / 0.036 mg/ml Solution for Injection for Horses, Cattle, Pigs and Sheep
Active ingredients: Epinephrine Acid Tartrate, Procaine Hydrochloride
Form
Injection
Species
Manufacturer
Fatro S.p.A.
VMD MA No.
11557/4002
What it's used for
- Infiltration anaesthesia and perineural anaesthesia (see section 3.5). Amended pages: March 2025 AN: 00644/2024 & 00645/2024
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Pronestesic 40 mg/ml / 0.036 mg/ml Solution for Injection for Horses, Cattle, Pigs and Sheep — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.
Amended pages: March 2025
AN: 00644/2024 & 00645/2024
2.5-10 ml of the veterinary medicinal product/animal (corresponding to 100-400 mg of
procaine hydrochloride + 0.09-0.36 mg of epinephrine bitartrate).
Perineural anaesthesia: inject close to the branch of the nerve
5-10 ml of the veterinary medicinal product/animal (corresponding to 200-400 mg of
procaine hydrochloride + 0.18-0.36 mg of epinephrine bitartrate).
For lower limb blocks in horses, the dose should be divided between two or more injection
sites depending on the dose. See also section 3.5.
The stopper may be broached up to 20 times.
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-
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-
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case of possible allergic cross reactions to p-aminobenzoic acid and sulphonamides.
Do not use:
-
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of tissue necrosis following complete circulatory arrest, due to the presence of
epinephrine (substance with a vasoconstrictor action);
-
a
It should be treated with antihistamines or corticoids.
b
It should be treated with epinephrine.
c
Particularly in horses, phenomena of excitability to the CNS are observed following the
administration of procaine.
d
Epinephrine-caused.
e
To local anaesthetics belonging to the esters subgroup.
f
Excitation of the central nervous system can occur in case of inadvertent intravascular
injection.
Short acting barbiturates should be administered as well as products for acidification of
urine, so as to support renal excretion.
g
Due to respiratory paralysis.
Reporting adverse events is important. It allows continuous safety monitoring of a veterinary
medicinal product. Reports should be sent, preferably via a veterinarian, to either the
marketing authorisation holder or its local representative or the national competent authority
via the national reporting system. See the package leaflet for respective contact details.
Common
(1 to 10 animals / 100 animals
treated):
Allergic reaction
a
.Rare
(1 to 10 animals / 10,000 animals
treated):
Anaphylactic-type reaction
b
.Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Hypotension;
Agitation
c
, Tremor
c
, Convulsion
c
;
Tachycardia
d
Undetermined frequency
(cannot be estimated from the
available data):
Hypersensitivity reaction
e
Restlessness
f
, Tremor
f
, Convulsion
f
, Depression
f
,
Death
f,g
Amended pages: March 2025
AN: 00644/2024 & 00645/2024
Special precautions for safe use in the target species:
To avoid inadvertent intravascular administration, correct placement of the injection needle
should be verified thoroughly by aspiration to check for the absence of blood before injecting.
Due to local tissue damage, wounds or abscesses may be difficult to anaesthetise using
local anaesthetics.
Perform local anaesthesia at ambient temperature. At higher temperatures, the risk of toxic
reactions is higher owing to the greater absorption of procaine.
As with other local anaesthetics containing procaine, the veterinary medicinal product should
be used with caution in animals with epilepsy or with changes in respiratory or renal function.
When injected near to wound edges, the veterinary medicinal product may lead to necrosis
along the edges.
The veterinary medicinal product should be used with caution in lower limb blocks due to
the risk of digital ischaemia.
Use with caution in horses due to risk of coat colour at the site of injection turning
permanently white.
Amended pages: March 2025
AN: 00644/2024 & 00645/2024
Special precautions to be taken by the person administering the veterinary medicinal product
to animals
People with known hypersensitivity to procaine
the ester group as well as derivatives of p-aminobenzoic acid and sulphonamides should
avoid contact with the veterinary medicinal product.
The veterinary medicinal product may be irritant to the skin, eyes and oral mucosa. Avoid
direct contact with the veterinary medicinal product. In case of spillage onto skin, eyes or
oral mucosa, rinse immediately with plenty of water. If irritation occurs, seek medical advice
immediately and show the package leaflet or the label to the physician.
Accidental self-injection may result in cardiorespiratory and/or CNS effects. Care should be
taken to avoid accidental self-injection. In case of accidental self-injection, seek medical
advice immediately and show the package leaflet or the label to the physician. Do not drive.
Special precautions for the protection of the environment:
Not applicable.
aminobenzoic acid, a sulphonamide antagonist.
Procaine prolongs the action of myorelaxants.
Procaine potentiates the action of antiarrhythmics e.g. procainamide.
Epinephrine potentiates the action of analgesic anaesthetics on the heart.
Do not use with cyclopropane- or halothane-based volatile anaesthetics, as they increase
cardiac sensitivity to epinephrine (a sympathomimetic) and may cause arrhythmia.
Due to these interactions, the veterinarian may adjust the dosage and should carefully
monitor the effects on the animal.
Do not administer with other sympathomimetic agents as increased toxicity may result.
Hypertension may result if adrenaline is used with oxytocic agents.
An increased risk of arrhythmias may occur if adrenaline is used concomitantly with digitalis
glycoside (as digoxin).
Certain antihistaminics (as chlorpheniramine) may potentiate the effects of adrenaline.
Keep the vial in the outer carton in order to protect from light.
Meat and offal: Zero days
Milk: Zero hours
Pigs:
Meat and offal: Zero days
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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Other Products Containing Epinephrine Acid Tartrate
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