Procanest 40 mg/ml + 0.036 mg/ml Solution for Injection for Sheep
Active ingredients: Epinephrine Acid Tartrate, Procaine Hydrochloride
Form
Injection
Species
Manufacturer
VetViva Richter GmbH
VMD MA No.
57446/4021
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Procanest 40 mg/ml + 0.036 mg/ml Solution for Injection for Sheep — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.
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1. Local anaesthesia or by infiltration
Inject into the subcutis or around the area involved.
2.5 – 10 ml of the veterinary medicinal product/animal (i.e. 100 - 400 mg procaine
hydrochloride + 0.09 - 0.36 mg adrenaline tartrate)
2. Perineural anaesthesia
Inject close to the branch of the nerve.
5 – 10 ml of the veterinary medicinal product/animal (i.e. 200 – 400 mg procaine
hydrochloride + 0.18 - 0.36 mg adrenaline tartrate)
The rubber stopper can be punctured a maximum of 25 times.
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Do not use in cases of hypersensitivity to local anaesthetics belonging to the esters
subgroup or in case of possible allergic cross reactions to p-aminobenzoic acid and
sulphonamides.
Do not administer by the intravenous or the intra-articular route.
Do not use to anaesthetise regions with terminal circulation (e.g. ears, tail, penis,
etc.), owing to the risk of tissue necrosis following complete circulatory arrest, due to
the presence of adrenaline (a vasoconstrictor).
Do not use with cyclopropane- or halothane-based anaesthetics (see also section
3.8).
Common
(1 to 10 animals / 100 animals treated):
Allergic reaction
Rare
(1 to 10 animals / 10 000 animals treated):
Anaphylaxis
Undetermined frequency (cannot be
estimated from the available data):
Hypotension
, Tachycardia
;
Agitation
, Restlessness
, Tremor
5,6
,
Convulsion
5,6
, Depression
, Death
6,7
.
To procaine. A hypersensitivity to local anaesthetics belonging to the esters
subgroup is known. It should be treated with antihistamines or corticoids.
Anaphylactic reactions have been observed in rare cases. Allergic shock should be
treated with epinephrine.
Due to procaine.
In exceptional cases. Due to adrenaline.
Particularly in horses, phenomena of excitability to the CNS are observed following
the administration of procaine.
Excitation of the central nervous system can occur in case of inadvertent
intravascular injection. Short acting barbiturates should be administered, as well as
products for acidification of urine, so as to support renal excretion.
Due to respiratory paralysis.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.
effect of procaine itself is short (max. 30 to 60 minutes); with the addition of
adrenaline to the solution, the duration of action is prolonged up to 90 - 120 minutes.
The onset of anaesthetic effect is also dependent upon the target species and the
age of the animal.
Special precautions for safe use in the target species:
To avoid inadvertent intravenous administration, correct placement of the needle
should be verified by aspiration.
Due to local tissue damage wounds or abscesses may be difficult to anaesthetise
using local anaesthetics.
Perform local anaesthesia at ambient temperature. At higher temperatures, the risk
of toxic reactions is higher owing to the greater absorption of procaine.
As with other local anaesthetics containing procaine, the veterinary medicinal product
should be used with caution in animals with epilepsy, cardiac conduction
disturbances, bradycardia, hypovolaemic shock or with changes in respiratory or
renal function.
When injected near to wound edges, the veterinary medicinal product may lead to
necrosis along the edges.
The veterinary medicinal product should be used with caution in lower limb blocks
due to the risk of digital ischaemia.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
People with known hypersensitivity to adrenaline, procaine or other local
anaesthetics of the ester group as well as derivatives of p-aminobenzoic acid and
sulphonamides should avoid contact with the veterinary medicinal product.
This veterinary medicinal product may be irritant to the skin, eyes and oral mucosa.
Avoid contact with the skin, eyes and oral mucosa. Wash any splashes immediately
with plenty of water. Seek medical advice if irritation persists.
Accidental self-injection may result in cardiorespiratory and/or CNS effects. Care
should be taken to avoid accidental self-injection. In case of accidental self-injection
seek medical advice immediately and show the package leaflet or the label to the
physician. Do not drive.
Wash hands after use.
Special precautions for the protection of the environment:
Not applicable.
aminobenzoic acid, a sulphonamide antagonist. Procaine prolongs the effect of
muscle relaxants. Procaine increases the action of antiarrhythmics, e.g.
procainamide.
Adrenaline potentiates the action of analgesic anaesthetics on the heart.
Do not use with cyclopropane- or halothane-based anaesthetics, as they increase
cardiac sensitivity to adrenaline (a sympathomimetic) and may cause arrhythmia.
Do not administer with other sympathomimetic agents as increased toxicity may
result.
Hypertension may result if adrenaline is used with oxytocic agents.
An increased risk of arrhythmias may occur if adrenaline is used concomitantly with
digitalis glycoside (as digoxin).
Certain antihistaminics (as chlorpheniramine) may potentiate the effects of
adrenaline.
Due to these interactions, the veterinarian may adjust the dosage and should
carefully monitor the effects on the animal.
Keep the vial in the outer carton in order to protect from light.
Meat and offal: Zero days.
Milk: Zero hours.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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