Prinovox 40 mg + 4 mg Spot-on Solution for Small Cats and Ferrets
Active ingredients: Imidacloprid, Moxidectin
Form
Spot-on
Species
Manufacturer
Elanco Europe Ltd
VMD MA No.
00879/5090
What it's used for
medicinal product is only indicated when use against fleas and one or more of the other target parasites is indicated at the same time: •Ctenocephalides fe...
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Prescription required
Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.
Prinovox 40 mg + 4 mg Spot-on Solution for Small Cats and Ferrets — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.
other target parasites is indicated at the same time:
•Ctenocephalides felis),
•Otodectes cynotis),
•Notoedres cati
•Eucoleus aerophilus (syn. Capillaria aerophila
(adults),
•Aelurostrongylus abstrusus),
•Aelurostrongylus abstrusus (adults),
•Troglostrongylus brevior (adults),
•Thelazia callipaeda (adults),
•Dirofilaria immitis),
•
adults and adults of Toxocara cati and Ancylostoma tubaeforme).
The veterinary medicinal product can be used as part of a treatment strategy for flea
allergy dermatitis (FAD).
For ferrets
medicinal product is only indicated when use against fleas and the prevention of
heartworm disease is indicated at the same time.
•Ctenocephalides felis),
•Dirofilaria immitis).
possible.
Dosage schedule for cats:
The recommended minimum doses are 10 mg/kg bodyweight imidacloprid and 1.0
mg/kg bodyweight moxidectin, equivalent to 0.1 ml/kg bodyweight of the veterinary
medicinal product.
For treatment or prevention of infestations with the parasites indicated for use of this
veterinary medicinal product, the need for and frequency of re-treatment(s) should be
based on professional advice and should take into account the local epidemiological
situation and the animal’s lifestyle.
Weight of
cat
[kg]
Pipette size to be
used
Volume
[ml]
Imidacloprid
[mg/kg bw]
Moxidectin
[mg/kg bw]
≤ 4 kgPrinovox for small
cats and ferrets
0.4minimum of
minimum of 1Cats weighing over 4 kg bodyweight: use Prinovox spot-on solution for large cats
Flea treatment and prevention (Ctenocephalides felis)
One treatment prevents future flea infestation for 4 weeks. Existing pupae in the
environment may emerge for 6 weeks or longer after treatment is initiated, depending
upon climatic conditions. Therefore, it may be necessary to combine veterinary
medicinal product treatment with environmental treatments aimed at breaking the flea
life cycle in the surroundings. This can result in a more rapid reduction in the
household flea population. The veterinary medicinal product should be administered
at monthly intervals when used as part of a treatment strategy for flea allergy
dermatitis.
Treatment of ear mite infestation (Otodectes cynotis)
A single dose of the veterinary medicinal product should be administered. A further
veterinary examination 30 days after treatment is recommended as some animals
may require a second treatment. Do not apply directly to the ear canal.
Treatment of notoedric mange (Notoedres cati)
A single dose of the veterinary medicinal product should be administered.
Treatment of the lungworm Eucoleus aerophilus (syn. Capillaria aerophila) (adults)
A single dose of the veterinary medicinal product should be administered.
Prevention of Aelurostrongylus abstrusus
The veterinary medicinal product should be administered monthly.
Treatment of Aelurostrongylus abstrusus
The veterinary medicinal product should be administered monthly for three
consecutive months.
Treatment of Troglostrongylus brevior (adults)
The veterinary medicinal product should be administered monthly for two consecutive
months.
Treatment of the eye worm Thelazia callipaeda (adults)
A single dose of the veterinary medicinal product should be administered.
Heartworm prevention (Dirofilaria immitis)
Cats in areas endemic for heartworm, or those which have travelled to endemic
areas, may be infected with adult heartworms. Therefore prior to treatment with the
veterinary medicinal product, the advice provided in section 3.5 should be
considered.
For prevention of heartworm disease, the veterinary medicinal product must be
applied at regular monthly intervals during the time of the year when mosquitoes (the
intermediate hosts which carry and transmit heartworm larvae) are present. The
veterinary medicinal product may be administered throughout the year. The first dose
may be given after first possible exposure to mosquitoes, but not more than one
month after this exposure. Treatment should continue at regular monthly intervals
until 1 month after the last exposure to mosquitoes. To establish a treatment routine,
it is recommended that the same day or date be used each month. When replacing
another heartworm preventative product in a heartworm prevention programme, the
first treatment with the veterinary medicinal product must be given within 1 month of
the last dose of the former veterinary medicinal product.
In non-endemic areas there should be no risk of cats having heartworm. Therefore,
they can be treated without special precautions.
Roundworm and hookworm treatment (Toxocara cati and Ancylostoma tubaeforme)
In areas endemic for heartworm, monthly treatment may significantly reduce the risk
of re-infection caused by the respective roundworms and hookworms. In areas non-
endemic for heartworm, the veterinary medicinal product can be used as part of a
seasonal prevention programme against fleas and gastrointestinal nematodes.
Dosage schedule for ferrets:
One pipette of the veterinary medicinal product (0.4 ml) should be administered per
animal. Do not exceed the recommended dose.
For treatment or prevention of infestations with the parasites indicated for use of this
veterinary medicinal product, the need for and frequency of re-treatment(s) should be
based on professional advice and should take into account the local epidemiological
situation and the animal’s lifestyle.
Flea treatment and prevention (Ctenocephalides felis)
One treatment prevents future flea infestation for 3 weeks. Under heavy flea pressure
it may be necessary to repeat administration after 2 weeks.
Heartworm prevention (Dirofilaria immitis)
Ferrets in areas endemic for heartworm, or those which have travelled to endemic
areas, may be infected with adult heartworms. Therefore prior to treatment with the
veterinary medicinal product, the advice provided in section 3.5 should be
considered.
For prevention of heartworm disease, the veterinary medicinal product must be
applied at regular monthly intervals during the time of the year when mosquitoes (the
intermediate hosts which carry and transmit heartworm larvae) are present. The
veterinary medicinal product may be administered throughout the year. The first dose
may be given after first possible exposure to mosquitoes, but not more than one
month after this exposure. Treatment should continue at regular monthly intervals
until 1 month after the last exposure to mosquitoes.
In non-endemic areas there should be no risk of ferrets having heartworm. Therefore,
they can be treated without special precautions.
Method of administration
For external use only.
Remove one pipette from the package. Then hold the pipette in an upright position,
and twist and pull off the cap. Reverse the cap and use it to twist and remove the
seal from the pipette, as shown.
Part the fur on the animal's neck at the base of the skull until the skin is visible. Place
the tip of the pipette on the skin and squeeze the pipette firmly several times to
empty its contents directly onto the skin. Application at the base of the skull will
minimise the opportunity for the animal to lick the veterinary medicinal product. Apply
only to undamaged skin.
Do not use in cases of hypersensitivity to the active substances or to any of the
excipients.
For ferrets: Do not use Prinovox for large cats (0.8 ml) or Prinovox for dogs (any
size).
Do not use in dogs Instead, the corresponding “Prinovox for dogs” product, which
contains 100 mg/ml imidacloprid and 25 mg/ml moxidectin, must be used for dogs.
Do not use on canaries.
Rare
(1 to 10 animals / 10,000 animals
treated):
Application site greasy fur
Vomiting
Hypersensitivity reaction (local)
Erythema
Very rare
(< 1 animal / 10,000 animals treated,
including isolated reports):
Behavioural disorder (e.g. Agitation, Lethargy,
Inappetence)
Hypersalivation
Neurological signs
Pruritus
1
Disappear without further treatment.
Transiently noted and related to sensation at application site.
If the animal licks the application site immediately after treatment. This is not a sign
of intoxication and disappears within minutes without treatment. Correct application
will minimise licking of the application site.
If the animal licks the application site, in most cases transient.
In cats, transient.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.
over 2 kg and therefore the duration of effect might be shorter in these animals.
Brief contact of the animal with water on one or two occasions between monthly
treatments is unlikely to significantly reduce the efficacy of the veterinary medicinal
product. However, frequent shampooing or immersion of the animal in water after
treatment may reduce the efficacy of the veterinary medicinal product.
The possibility that other animals in the same household can be a source of re-
infection with fleas, mites, gastrointestinal nematodes, heartworm and/or lungworm
should be considered, and these should be treated as necessary with an appropriate
product.
Unnecessary use of antiparasitics or use deviating from the instructions given in the
SPC may increase the resistance selection pressure and lead to reduced efficacy.
The decision to use the veterinary medicinal product should be based on
confirmation of the parasitic species and burden, or of the risk of infestation based on
its epidemiological features, for each individual animal.
Special precautions for safe use in the target species:
The treatment of cats weighing less than 1 kg and ferrets weighing less than 0.8 kg
should be based on a benefit-risk assessment.
There is limited experience on the use of the veterinary medicinal product in sick and
debilitated animals, thus the veterinary medicinal product should only be used based
on a benefit-risk assessment for these animals.
Do not apply in the mouth, in the eyes or the ears of the animal.
Care should be taken that the veterinary medicinal product is not ingested by animals
and does not come into contact with the eyes or mouth of the recipient and/or other
animals.
Consider carefully the correct application method described in section 3.9, especially
that the veterinary medicinal product should be applied at the base of the skull in
order to minimise the risk for the animal to lick the veterinary medicinal product.
Do not allow recently treated animals to groom each other. Do not allow treated
animals to come into contact with untreated animals until the application site is dry.
It is recommended that cats and ferrets living in or travelling to areas endemic for
heartworm are treated monthly with the veterinary medicinal product to protect them
from heartworm disease.
Whilst the accuracy of diagnosis of heartworm infection is limited, it is recommended
that attempts be made to check the heartworm status of any cat and ferret aged over
6 months, before beginning prophylactic treatment, as use of the veterinary medicinal
product on cats or ferrets which have adult heartworms may cause serious adverse
effects, including death. If adult heartworm infection is diagnosed, the infection
should be treated in accordance with current scientific knowledge.
In certain individual cats Notoedres cati infestation may be severe. In these severe
cases concomitant supportive treatment is necessary as treatment with the veterinary
medicinal product alone may not be sufficient to prevent death of the animal.
The safety of the veterinary medicinal product has not been established in cats with
severe clinical signs of
cases should be based on the benefit-risk assessment of the veterinarian.
Imidacloprid is toxic for birds, especially canaries.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
In very rare cases the veterinary medicinal product may cause skin sensitisation or
transient skin reactions (for example numbness, irritation or burning/tingling
sensation).
In very rare cases the veterinary medicinal product may cause respiratory irritation in
sensitive individuals.
People with known hypersensitivity to benzyl alcohol, imidacloprid or moxidectin
should administer the veterinary medicinal product with caution.
Ingestion of the veterinary medicinal product is harmful. In order to prevent children
getting access to pipettes, keep the pipette in the original packaging until ready for
use and dispose of used pipettes immediately.
After application, treated animals should not be handled, especially children, until the
application site is dry. This can be ensured by treating animals in the evening.
Do not allow recently treated animals to sleep with owners, especially children.
Avoid contact with skin, eyes or mouth.
In case of accidental spillage onto skin, wash off immediately with soap and water.
If the veterinary medicinal product accidentally gets into eyes, they should be
thoroughly flushed with water.
If skin or eye symptoms persist, or the veterinary medicinal product is accidentally
swallowed, seek medical advice immediately and show the package leaflet or the
label to the physician.
Do not eat, drink or smoke during application.
Wash hands thoroughly after use.
Special precautions for the protection of the environment:
Moxidectin fulfils the criteria for a persistent, bioaccumulative and toxic substance;
therefore, exposure of the environment to moxidectin should be minimised as much
as possible. The veterinary medicinal product should not enter water courses as it
has harmful effects on aquatic organisms. Moxidectin is highly toxic to aquatic
organisms.
See also section 5.5.
Other precautions:
The solvent in the veterinary medicinal product may stain or damage certain
materials including leather, fabrics, plastics and finished surfaces. Allow the
application site to dry before permitting contact with such materials.
macrocyclic lactone should be administered.
No interactions between the veterinary medicinal product and routinely used
veterinary medicinal products or medical or surgical procedures have been observed.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
Prinovox 40 mg + 4 mg Spot-on Solution for Small Cats and Ferrets Prices by Online retailer
Prinovox 40 mg + 4 mg Spot-on Solution for Small Cats and Ferrets is a prescription-only veterinary medicine (POM-V). Prices are listed for information, with every retailer shown on equal terms. To buy it online you need a written prescription from your vet, which the retailer will ask for at checkout. Under the CMA Order your vet must provide one on request, with the fee capped at £21 from 2027. Your prescription rights →
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