POM-V
Prescription Required
Companion Animal
Prinocate 80 mg/8 mg Spot-on Solution for Large Cats
Active ingredients: Imidacloprid, Moxidectin
Form
Spot-on
Species
Cats
Manufacturer
KRKA, d.d., Novo mesto
VMD MA No.
01656/4182
What it's used for
(adults), The prevention of lungworm disease (L3/L4 larvae of Aelurostrongylus abstrusus), The treatment of the lungworm Aelurostrongylus abstrusus (adults...
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Clinical information
Prinocate 80 mg/8 mg Spot-on Solution for Large Cats — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.
(adults),
The prevention of lungworm disease (L3/L4 larvae of Aelurostrongylus abstrusus),
The treatment of the lungworm Aelurostrongylus abstrusus (adults),
The treatment of the eye worm Thelazia callipaeda (adults),
AN: 01755/2024 & 01759/2024
The prevention of heartworm disease (L3 and L4 larvae of Dirofilaria immitis),
The treatment of infections with gastrointestinal nematodes (L4 larvae, immature
adults and adults of Toxocara cati and Ancylostoma tubaeforme).
The veterinary medicinal product can be used as part of a treatment strategy for flea
allergy dermatitis (FAD).
The prevention of lungworm disease (L3/L4 larvae of Aelurostrongylus abstrusus),
The treatment of the lungworm Aelurostrongylus abstrusus (adults),
The treatment of the eye worm Thelazia callipaeda (adults),
AN: 01755/2024 & 01759/2024
The prevention of heartworm disease (L3 and L4 larvae of Dirofilaria immitis),
The treatment of infections with gastrointestinal nematodes (L4 larvae, immature
adults and adults of Toxocara cati and Ancylostoma tubaeforme).
The veterinary medicinal product can be used as part of a treatment strategy for flea
allergy dermatitis (FAD).
The recommended minimum doses are 10 mg/kg bodyweight imidacloprid and 1.0
mg/kg bodyweight moxidectin, equivalent to 0.1 ml/kg bodyweight of the veterinary
medicinal product.
The treatment schedule should be based on individual veterinary diagnosis and on
the local epidemiological situation.
Administer in accordance with the following table:
Cats
[kg]
Pipette size to be used
Volume
[ml]
Imidacloprid
[mg/kg b.w.]
Moxidectin
[mg/kg b.w.]
>4-8
imidacloprid/moxidectin 80 mg/8
mg spot-on solution for large cats
0.810-201-2
>8
the appropriate combination of pipettes 0.8 ml and 0.4 ml (intended for use
in small cats kg and ferrets) to provide the recommended dose (the
minimum recommended dose is 0.1 ml veterinary medicinal product/kg
bodyweight)
Flea treatment and prevention (Ctenocephalides felis):
One treatment prevents future flea infestation for 4 weeks. Pre-existing pupae in the
environment may emerge for 6 weeks or longer after treatment is initiated, depending
upon climatic conditions. Therefore, it may be necessary to combine treatment with
this veterinary medicinal product with environmental treatments aimed at breaking
the flea life cycle in the surroundings. This can result in a more rapid reduction in the
household flea population. The veterinary medicinal product should be administered
at monthly intervals when used as part of a treatment strategy for flea allergy
dermatitis.
Treatment of ear mite infestation (Otodectes cynotis):
A single dose of the veterinary medicinal product should be administered. A further
veterinary examination 30 days after treatment is recommended as some animals
may require a second treatment. Do not apply directly to the ear canal.
Treatment of notoedric mange (Notoedres cati
A single dose of the veterinary medicinal product should be administered.
Treatment of the lungworm Eucoleus aerophilus (syn. Capillaria aerophila) (adults):
A single dose of the veterinary medicinal product should be administered.
Prevention of :
The veterinary medicinal product should be administered monthly.
AN: 01755/2024 & 01759/2024
Treatment of Aelurostrongylus abstrusus:
The veterinary medicinal product should be administered monthly for three
consecutive months.
Treatment of the eye worm Thelazia callipaeda (adults):
A single dose of the veterinary medicinal product should be administered.
Heartworm prevention (Dirofilaria immitis):
Cats in areas endemic for heartworm, or those which have travelled to endemic
areas, may be infected with adult heartworms. Therefore prior to treatment with the
veterinary medicinal product, the advice provided in section 3.5 should be
considered.
For prevention of heartworm disease, the veterinary medicinal product must be
applied at regular monthly intervals during the time of the year when mosquitoes (the
intermediate hosts which carry and transmit heartworm larvae) are present. The
veterinary medicinal product may be administered throughout the year or at least 1
month before the first expected exposure to mosquitoes. Treatment should continue
at regular monthly intervals until 1 month after the last exposure to mosquitoes. To
establish a treatment routine, it is recommended that the same day or date be used
each month. When replacing another heartworm preventative veterinary medicinal
product in a heartworm prevention programme, the first treatment with this veterinary
medicinal product must be given within 1 month of the last dose of the former
medication.
In non-endemic areas there should be no risk of cats having heartworm. Therefore
they can be treated without special precautions.
Roundworm and hookworm treatment (Toxocara cati and Ancylostoma tubaeforme):
In areas endemic for heartworm, monthly treatment may significantly reduce the risk
of re-infection caused by the respective roundworms and hookworms. In areas non-
endemic for heartworm, the veterinary medicinal product can be used as part of a
seasonal prevention programme against fleas and gastrointestinal nematodes.
Method of administration:
1. Remove the pipette from its packaging. Hold the pipette in an upright position,
twist and pull the cap off.
2. Turn the cap around and place the other end of the cap back on the pipette. Push
and twist the cap to break the seal, then remove the cap from the pipette.
3. Part the coat on the animal’s neck at the base of the skull until the skin is visible.
Place the tip of the pipette onto the skin and squeeze the pipette several times to
empty its contents completely and directly onto the skin in one spot. Avoid contact
between the veterinary medicinal product and your fingers.
AN: 01755/2024 & 01759/2024
Application at the base of the skull will minimise the opportunity for the animal to lick
the veterinary medicinal product. The veterinary medicinal product should only be
applied to undamaged skin.
mg/kg bodyweight moxidectin, equivalent to 0.1 ml/kg bodyweight of the veterinary
medicinal product.
The treatment schedule should be based on individual veterinary diagnosis and on
the local epidemiological situation.
Administer in accordance with the following table:
Cats
[kg]
Pipette size to be used
Volume
[ml]
Imidacloprid
[mg/kg b.w.]
Moxidectin
[mg/kg b.w.]
>4-8
imidacloprid/moxidectin 80 mg/8
mg spot-on solution for large cats
0.810-201-2
>8
the appropriate combination of pipettes 0.8 ml and 0.4 ml (intended for use
in small cats kg and ferrets) to provide the recommended dose (the
minimum recommended dose is 0.1 ml veterinary medicinal product/kg
bodyweight)
Flea treatment and prevention (Ctenocephalides felis):
One treatment prevents future flea infestation for 4 weeks. Pre-existing pupae in the
environment may emerge for 6 weeks or longer after treatment is initiated, depending
upon climatic conditions. Therefore, it may be necessary to combine treatment with
this veterinary medicinal product with environmental treatments aimed at breaking
the flea life cycle in the surroundings. This can result in a more rapid reduction in the
household flea population. The veterinary medicinal product should be administered
at monthly intervals when used as part of a treatment strategy for flea allergy
dermatitis.
Treatment of ear mite infestation (Otodectes cynotis):
A single dose of the veterinary medicinal product should be administered. A further
veterinary examination 30 days after treatment is recommended as some animals
may require a second treatment. Do not apply directly to the ear canal.
Treatment of notoedric mange (Notoedres cati
A single dose of the veterinary medicinal product should be administered.
Treatment of the lungworm Eucoleus aerophilus (syn. Capillaria aerophila) (adults):
A single dose of the veterinary medicinal product should be administered.
Prevention of :
The veterinary medicinal product should be administered monthly.
AN: 01755/2024 & 01759/2024
Treatment of Aelurostrongylus abstrusus:
The veterinary medicinal product should be administered monthly for three
consecutive months.
Treatment of the eye worm Thelazia callipaeda (adults):
A single dose of the veterinary medicinal product should be administered.
Heartworm prevention (Dirofilaria immitis):
Cats in areas endemic for heartworm, or those which have travelled to endemic
areas, may be infected with adult heartworms. Therefore prior to treatment with the
veterinary medicinal product, the advice provided in section 3.5 should be
considered.
For prevention of heartworm disease, the veterinary medicinal product must be
applied at regular monthly intervals during the time of the year when mosquitoes (the
intermediate hosts which carry and transmit heartworm larvae) are present. The
veterinary medicinal product may be administered throughout the year or at least 1
month before the first expected exposure to mosquitoes. Treatment should continue
at regular monthly intervals until 1 month after the last exposure to mosquitoes. To
establish a treatment routine, it is recommended that the same day or date be used
each month. When replacing another heartworm preventative veterinary medicinal
product in a heartworm prevention programme, the first treatment with this veterinary
medicinal product must be given within 1 month of the last dose of the former
medication.
In non-endemic areas there should be no risk of cats having heartworm. Therefore
they can be treated without special precautions.
Roundworm and hookworm treatment (Toxocara cati and Ancylostoma tubaeforme):
In areas endemic for heartworm, monthly treatment may significantly reduce the risk
of re-infection caused by the respective roundworms and hookworms. In areas non-
endemic for heartworm, the veterinary medicinal product can be used as part of a
seasonal prevention programme against fleas and gastrointestinal nematodes.
Method of administration:
1. Remove the pipette from its packaging. Hold the pipette in an upright position,
twist and pull the cap off.
2. Turn the cap around and place the other end of the cap back on the pipette. Push
and twist the cap to break the seal, then remove the cap from the pipette.
3. Part the coat on the animal’s neck at the base of the skull until the skin is visible.
Place the tip of the pipette onto the skin and squeeze the pipette several times to
empty its contents completely and directly onto the skin in one spot. Avoid contact
between the veterinary medicinal product and your fingers.
AN: 01755/2024 & 01759/2024
Application at the base of the skull will minimise the opportunity for the animal to lick
the veterinary medicinal product. The veterinary medicinal product should only be
applied to undamaged skin.
Do not use in kittens under 9 weeks of age.
Do not use in cases of hypersensitivity to the active substances or to any of the
excipients.
Do not use this veterinary medicinal product for large cats (0.8 ml) or the veterinary
medicinal product for dogs (any size) in ferrets.
For dogs, the corresponding veterinary medicinal product, which contains 100 mg/ml
imidacloprid and 25 mg/ml moxidectin, must be used.
Do not use on canaries.
Do not use in cases of hypersensitivity to the active substances or to any of the
excipients.
Do not use this veterinary medicinal product for large cats (0.8 ml) or the veterinary
medicinal product for dogs (any size) in ferrets.
For dogs, the corresponding veterinary medicinal product, which contains 100 mg/ml
imidacloprid and 25 mg/ml moxidectin, must be used.
Do not use on canaries.
Cats:
Rare
(1 to 10 animals / 10,000
animals treated):
Vomiting
Application site greasy fur
, Application site
erythema
, Hypersensitivity reaction.
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Behavioural disorders (e.g. agitation, lethargy)
Inappetence
Neurological signs
Undetermined frequency
(cannot be estimated from the
available data):
Pruritus
Hypersalivation
1
These signs disappear without further treatment.
Local.
Transiently noted and related to sensation at application site.
Most occur transiently and if animal licks the application site after treatment (see
section 3.10).
Transient.
Occurs if the animal licks the application site immediately after treatment. This is not
a sign of intoxication and disappears within minutes without treatment. Correct
application will minimise licking of the application site.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.
Rare
(1 to 10 animals / 10,000
animals treated):
Vomiting
Application site greasy fur
, Application site
erythema
, Hypersensitivity reaction.
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Behavioural disorders (e.g. agitation, lethargy)
Inappetence
Neurological signs
Undetermined frequency
(cannot be estimated from the
available data):
Pruritus
Hypersalivation
1
These signs disappear without further treatment.
Local.
Transiently noted and related to sensation at application site.
Most occur transiently and if animal licks the application site after treatment (see
section 3.10).
Transient.
Occurs if the animal licks the application site immediately after treatment. This is not
a sign of intoxication and disappears within minutes without treatment. Correct
application will minimise licking of the application site.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.
Brief contact of the animal with water on one or two occasions between monthly
treatments is unlikely to significantly reduce the efficacy of the veterinary medicinal
product. However, frequent shampooing or immersion of the animal in water after
treatment may reduce the efficacy of the veterinary medicinal product.
Parasite resistance to any particular class of anthelmintic may develop following
frequent, repeated use of an anthelmintic of that class. Therefore, the use of this
veterinary medicinal product should be based on the assessment of each individual
case and on local epidemiological information about the current susceptibility of the
target species in order to limit the possibility of a future selection for resistance.
The use of the veterinary medicinal product should be based on the confirmed
diagnosis of mixed infection (or risk of infection, where prevention applies) at the
same time (see also sections 3.2 and 3.9).
Special precautions for safe use in the target species:
There is limited experience on the use of the veterinary medicinal product in sick and
debilitated animals, thus the veterinary medicinal product should only be used based
on a benefit-risk assessment for these animals.
The veterinary medicinal product should only be applied to undamaged skin.
Care should be taken that the content of the pipette or the applied dose does not
come into contact with the eyes or mouth of the recipient and/or other animals. Do
not allow recently treated animals to groom each other.
It is recommended that cats living in, or travelling to areas endemic for heartworm are
treated monthly with the veterinary medicinal product to protect them from heartworm
disease.
Whilst the accuracy of diagnosis of heartworm infection is limited, it is recommended
that attempts be made to check the heartworm status of any cat aged over 6 months,
before beginning prophylactic treatment, as use of the veterinary medicinal product
AN: 01755/2024 & 01759/2024
on cats which have adult heartworms may cause serious adverse effects, including
death. If adult heartworm infection is diagnosed, the infection should be treated in
accordance with current scientific knowledge.
In certain individual cats Notoedres cati infestation may be severe. In these severe
cases concomitant supportive treatment is necessary as treatment with the veterinary
medicinal product alone may not be sufficient to prevent death of the animal.
Imidacloprid is toxic for birds, especially canaries.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
In order to prevent children from getting access to pipettes, keep the pipette in the
original packaging until ready for use and dispose of used pipettes immediately.
Do not ingest. In case of accidental ingestion, seek medical advice immediately and
show the package leaflet or the label to the physician.
People with known hypersensitivity to benzyl alcohol, imidacloprid or moxidectin
should administer the veterinary medicinal product with caution. In very rare cases
the veterinary medicinal product may cause skin sensitisation or transient skin
reactions (for example numbness, irritation or burning/tingling sensation).
In very rare cases the veterinary medicinal product may cause respiratory irritation in
sensitive individuals.
If the veterinary medicinal product accidentally gets into eyes, they should be
thoroughly flushed with water.
Avoid contact with skin, eyes or mouth.
In case of accidental spillage onto skin, wash off immediately with soap and water.
Wash hands thoroughly after use.
If skin or eye symptoms persist, seek medical advice immediately and show the
package leaflet or the label to the physician.
Do not eat, drink or smoke during application.
Treated animals should not be handled especially by children until the application site
is dry. Therefore, it is recommended to apply the veterinary medicinal product in the
evening. Recently treated animals should not be allowed to sleep in the same bed as
their owner, especially children.
Special precautions for the protection of the environment:
Not applicable.
Other precautions:
The solvent in the veterinary medicinal product may stain or damage certain
materials including leather, fabrics, plastics and finished surfaces. Allow the
application site to dry before permitting contact with such materials.
AN: 01755/2024 & 01759/2024
treatments is unlikely to significantly reduce the efficacy of the veterinary medicinal
product. However, frequent shampooing or immersion of the animal in water after
treatment may reduce the efficacy of the veterinary medicinal product.
Parasite resistance to any particular class of anthelmintic may develop following
frequent, repeated use of an anthelmintic of that class. Therefore, the use of this
veterinary medicinal product should be based on the assessment of each individual
case and on local epidemiological information about the current susceptibility of the
target species in order to limit the possibility of a future selection for resistance.
The use of the veterinary medicinal product should be based on the confirmed
diagnosis of mixed infection (or risk of infection, where prevention applies) at the
same time (see also sections 3.2 and 3.9).
Special precautions for safe use in the target species:
There is limited experience on the use of the veterinary medicinal product in sick and
debilitated animals, thus the veterinary medicinal product should only be used based
on a benefit-risk assessment for these animals.
The veterinary medicinal product should only be applied to undamaged skin.
Care should be taken that the content of the pipette or the applied dose does not
come into contact with the eyes or mouth of the recipient and/or other animals. Do
not allow recently treated animals to groom each other.
It is recommended that cats living in, or travelling to areas endemic for heartworm are
treated monthly with the veterinary medicinal product to protect them from heartworm
disease.
Whilst the accuracy of diagnosis of heartworm infection is limited, it is recommended
that attempts be made to check the heartworm status of any cat aged over 6 months,
before beginning prophylactic treatment, as use of the veterinary medicinal product
AN: 01755/2024 & 01759/2024
on cats which have adult heartworms may cause serious adverse effects, including
death. If adult heartworm infection is diagnosed, the infection should be treated in
accordance with current scientific knowledge.
In certain individual cats Notoedres cati infestation may be severe. In these severe
cases concomitant supportive treatment is necessary as treatment with the veterinary
medicinal product alone may not be sufficient to prevent death of the animal.
Imidacloprid is toxic for birds, especially canaries.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
In order to prevent children from getting access to pipettes, keep the pipette in the
original packaging until ready for use and dispose of used pipettes immediately.
Do not ingest. In case of accidental ingestion, seek medical advice immediately and
show the package leaflet or the label to the physician.
People with known hypersensitivity to benzyl alcohol, imidacloprid or moxidectin
should administer the veterinary medicinal product with caution. In very rare cases
the veterinary medicinal product may cause skin sensitisation or transient skin
reactions (for example numbness, irritation or burning/tingling sensation).
In very rare cases the veterinary medicinal product may cause respiratory irritation in
sensitive individuals.
If the veterinary medicinal product accidentally gets into eyes, they should be
thoroughly flushed with water.
Avoid contact with skin, eyes or mouth.
In case of accidental spillage onto skin, wash off immediately with soap and water.
Wash hands thoroughly after use.
If skin or eye symptoms persist, seek medical advice immediately and show the
package leaflet or the label to the physician.
Do not eat, drink or smoke during application.
Treated animals should not be handled especially by children until the application site
is dry. Therefore, it is recommended to apply the veterinary medicinal product in the
evening. Recently treated animals should not be allowed to sleep in the same bed as
their owner, especially children.
Special precautions for the protection of the environment:
Not applicable.
Other precautions:
The solvent in the veterinary medicinal product may stain or damage certain
materials including leather, fabrics, plastics and finished surfaces. Allow the
application site to dry before permitting contact with such materials.
AN: 01755/2024 & 01759/2024
During treatment with the veterinary medicinal product no other antiparasitic
macrocyclic lactone should be administered.
No interactions between the veterinary medicinal product and routinely used
veterinary medicinal products or medical or surgical procedures have been observed.
AN: 01755/2024 & 01759/2024
macrocyclic lactone should be administered.
No interactions between the veterinary medicinal product and routinely used
veterinary medicinal products or medical or surgical procedures have been observed.
AN: 01755/2024 & 01759/2024
Store in the original package in order to protect from light and moisture. This
veterinary medicinal product does not require any special temperature storage
conditions.
AN: 01755/2024 & 01759/2024
veterinary medicinal product does not require any special temperature storage
conditions.
AN: 01755/2024 & 01759/2024
Not applicable.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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