POM-V Prescription Required

Poulvac E. coli Lyophilisate for Suspension for Spray Vaccination for Chickens and Turkeys or for Use in Drinking Water for Chickens

Active ingredient: Escherichia coli

Form

Spray

Species

Chickens Turkeys

Manufacturer

Zoetis UK Limited

VMD MA No.

42058/5046

What it's used for

For active immunisation of broiler chickens, future layer/breeders and turkeys in order to reduce mortality and lesions (pericarditis, perihepatitis, airsa...

Full indications, dosage and side effects ↓

View official SPC (PDF)

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Paying less for Escherichia coli

1

Ask your vet for a written prescription

They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

Fill it at a registered online retailer

The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

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Prescription required

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Clinical information

Poulvac E. coli Lyophilisate for Suspension for Spray Vaccination for Chickens and Turkeys or for Use in Drinking Water for Chickens — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

For active immunisation of broiler chickens, future layer/breeders and turkeys in order
to reduce mortality and lesions (pericarditis, perihepatitis, airsacculitis) associated
with Escherichia coli serotype O78.
Onset of immunity:
Chickens: 2 weeks after vaccination for the reduction of lesions. The onset of
immunity has not been established for the mortality claim.
Turkeys: 3 weeks after second vaccination for the reduction of lesions and mortality.
Duration of immunity:
Chickens: 8 weeks for the reduction of lesions and 12 weeks for the reduction of
mortality (spray). 12 weeks for the reduction of lesions and mortality (drinking water).
Turkeys: duration of immunity has not been established.

Revised: June 2024
AN: 02272/2022
A cross protection study showed reduction of incidence and severity of airsacculitis
caused by
these serotypes no onset of immunity or duration of immunity was established.

Do not vaccinate animals undergoing antibacterial or immunosuppressive treatment.

Chickens (broilers, future layers/breeders) and turkeys:
None known.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See also section 16 of the
package leaflet for contact details.

Vaccinate healthy animals only.
Do not use antibiotic treatment within 1 week before and after vaccination because
antibiotic treatment might impair the efficacy of the vaccine.
No information is available on the influence of high levels of maternally derived
antibodies on the efficacy.

Special precautions for use in animals
The vaccine strain can be detected in tissues (liver, heart) until 6 days (chickens) or
in tissues (thoracic air sacs) 4 days (turkeys) post vaccination. Vaccinated birds may
excrete the vaccine strain by faecal route for up to 5 weeks (chickens) or 7 days
(turkeys) post vaccination and the vaccine may remain present in the environment
until the end of the finishing or rearing period (chickens) or for 7 days (turkeys).
Therefore, it is recommended to clean and disinfect bird houses where the vaccine
was applied after completion of the finishing or rearing period.
The vaccine strain may spread to in-contact birds. The vaccine strain can be
identified by its growth properties on biological growth media: it shows normal growth
on MacConkey and trypticase soy agar, while no colonies are observed when plated
without aromatic amino acids (minimum agar).
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Apply the usual aseptic precautions to all administration procedures.
The use of eye-protection, gloves and a nose-mouth mask by the operator is advised
during administration. Immunosuppressed people should not be present during
administration of the vaccine. Disinfect hands and equipment after use.
Personnel involved in attending vaccinated animals should follow general hygiene
principals and take particular care in handling litter from recently vaccinated animals.
Special precautions for the protection of the environment
Not applicable.
Other precautions
Immunisation has to be considered as one component in a complex control program
that addresses all important hygienic and health factors for poultry.

Revised: June 2024
AN: 02272/2022

No information is available on the safety and efficacy of this vaccine when used with
any other veterinary medicinal product. A decision to use this vaccine before or after
any other veterinary medicinal product therefore needs to be made on a case by
case basis.

Store and transport refrigerated (2 °C – 8 °C). Do not freeze.
Keep the vial in the outer carton in order to protect from light.

- 9.1 x 10
CFU*
* Colony forming units when grown on trypticase soy agar plates.
For the full list of excipients, see section

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.