POM-V Prescription Required

Coliprotec F4/F18 lyophilisate for oral suspension

Active ingredient: Escherichia coli

Form

Liquid

Species

Pigs

Manufacturer

Elanco GmbH

VMD MA No.

EU/2/16/202/001-003

What it's used for

For active immunisation of pigs from 18 days of age against enterotoxigenic F4- positive and F18-positive -E. coli diarrhoea (PWD) in infected pigs; -E. co...

Full indications, dosage and side effects ↓

View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for Escherichia coli

1

Ask your vet for a written prescription

They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

Fill it at a registered online retailer

The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

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Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Coliprotec F4/F18 lyophilisate for oral suspension — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

For active immunisation of pigs from 18 days of age against enterotoxigenic F4-
positive and F18-positive
-E. coli diarrhoea
(PWD) in infected pigs;
-E.
coli from infected pigs.
Onset of immunity: 1 week
Duration of immunity: 3 weeks

Revised: July 2024
AN: 02552/2023

None.

Pigs:
None known.
Reporting adverse events is important. It allows continuous safety monitoring of
a veterinary medicinal product. Reports should be sent, preferably via a
veterinarian, to either the marketing authorisation holder or the national
competent authority via the national reporting system. See also section 16 of
the package leaflet for contact details.

Revised: July 2024
AN: 02552/2023

It is not recommended to vaccinate animals undergoing immunosuppressive
treatment or to vaccinate animals undergoing antibacterial treatment effective
against
Vaccinate healthy animals only.

Special precautions for use in animals
The vaccine strains may be excreted by vaccinated piglets for at least 14 days
following vaccination. The vaccine strains readily spread to other pigs in contact
with vaccinated pigs. Unvaccinated pigs in contact with vaccinated pigs will
harbour and shed the vaccine strains similarly to vaccinated pigs. During this
time, the contact of immunosuppressed pigs with vaccinated pigs should be
avoided.
Special precautions to be taken by the person administering the veterinary
medicinal product to animals
Personal protective equipment consisting of protective disposable gloves and
safety glasses should be worn when handling the veterinary medicinal product.
In case of accidental ingestion seek medical advice immediately and show the
package leaflet or the label to the physician. In case of spillage onto skin, rinse
with water and seek medical advice immediately and show the package leaflet
or the label to the physician.
Special precautions for the protection of the environment
Not applicable.
Other precautions
Not applicable.

No information is available on the safety and efficacy of this vaccine when used
with any other veterinary medicinal product. A decision to use this vaccine
before or after any other veterinary medicinal product therefore needs to be
made on a case by case basis.

Store and transport refrigerated (2 C – 8 C).
Protect from light.

-
volume of water that the pigs will drink during a 4-hour time period.
-
dilute the reconstituted vaccine in the needed volume of the dosing pump stock
solution. The volume of stock solution is calculated using the volume of water
that the pigs will drink during a 4-hour time period multiplied by the dosing
pump rate (in decimal). As an example, for a 4-hour consumption of 22 litres
and a dosing pump rate of 1%, the volume of the stock solution should be 22
litres x 0.01 = 220 ml.
In case of concerns about the presence of disinfectant residues in the drinking
water, such as chlorine, it is recommended to add skimmed milk powder as a
stabiliser into the drinking water prior to adding the vaccine. The final
concentration of the skimmed milk powder should be 5 g/litre.
4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary
A rectal temperature up to 41.2 °C may occur in individual animals within the
first 24 hours after administration of a 10-fold overdose.
4.11 Withdrawal period(s)
Zero days.
5.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.