POM-V Prescription Required

Permacyl 236.3 mg/ml Powder and Solvent for Suspension for Injection for Cattle

Active ingredients: Penethamate Hydriodide, micronised

Form

Injection

Species

Cattle

Manufacturer

Divasa - Farmavic S.A

VMD MA No.

33229/4005

What it's used for

Treatment of mastitis in lactating cows caused by Streptococcus uberis, Streptococcus dysgalactiaeStreptococcus agalactiaeStaphylococcus aureus (beta-lacta...

Full indications, dosage and side effects ↓

View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for Penethamate Hydriodide + mic...

1

Ask your vet for a written prescription

They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

Fill it at a registered online retailer

The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Your prescription rights → VMD register of retailers →

Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Permacyl 236.3 mg/ml Powder and Solvent for Suspension for Injection for Cattle — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

Treatment of mastitis in lactating cows caused by Streptococcus uberis,
Streptococcus dysgalactiaeStreptococcus agalactiaeStaphylococcus aureus
(beta-lactamase non-producing), susceptible to penicillin.

For deep intramuscular use.
Directions for use: Reconstitute the suspension using the entire contents of the
solvent vial.
To provide the correct dose:
Use the powder vial, which contains penethamate hydriodide 5,000,000 IU with the
solvent vial, which contains 18 ml of a sterile solvent.
Or alternatively, use the powder vial, which contains penethamate hydriodide
10,000,000 IU with the solvent vial, which contains 36 ml of a sterile solvent.
Shake well after reconstitution. A minimum of 10 inversions of vials can be
necessary.
Each ml of suspension contains 250,000 IU (236.3 mg) of penethamate hydriodide.
Dose: 15,000 IU (14.2 mg) of penethamate hydriodide per kg of body weight / day
(equivalent to 6 ml of reconstituted medicinal product / 100 kg body weight) for three
to four consecutive days. Shake well before use.
Administer the recommended daily dose every 24 hours, for three to four consecutive
administrations.
To ensure administration of a correct dose, body weight should be determined as
accurately as possible.
The recommended maximum volume to be administered at a single injection site is
20 ml.
The stopper should not be punctured more than 10 times.

Do not use in cases of hypersensitivity to penicillins, cephalosporins, and/or any of
the excipients.
Do not administer intravenously.
Do not use in lagomorphs and rodents such as guinea pigs, hamsters or gerbils.
Do not administer to animals with renal disease including anuria or oliguria.

In very rare cases the symptoms of adverse reactions range from mild skin reactions
such as urticaria and dermatitis to severe reactions such as anaphylactic shock with
tremors, vomiting, salivation, gastrointestinal disorders and laryngeal oedema.
In some situations the treatment may lead to secondary infections due to overgrowth
of non-target organisms.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).

Treatment should be carried out during lactation.

This veterinary medicinal product does not contain any antimicrobial preservative.
Special precautions for use in animals
Using penethamate hydriodide for the treatment of mastitis must be accompanied by
hygienic measures to prevent reinfection.
Use of the product should be based on susceptibility testing of the bacteria isolated
from the animal. If this is not possible, therapy should be based on local (regional,
farm level) epidemiological information about susceptibility of the target bacteria.”The
veterinary medicinal product is not effective against beta-lactamase producing
organisms.
Official national and regional antimicrobial policies should be taken into account
when the product is used.
Use of the product deviating from the instructions given in the SPC may increase the
prevalence of bacteria resistant to benzylpenicillin and may decrease the
effectiveness of treatment with other beta-lactam antimicrobials due to the potential
for cross-resistance.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
•

Revised: July 2020
AN: 01181/2019
injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may
lead to cross-reactions to cephalosporins and . Allergic reactions to
these substances may occasionally be serious.
•
excipients should avoid contact with the veterinary medicinal product..
•
handling the veterinary medicinal product to avoid contact sensitization.
•
exposure such as a skin rash, you should seek medical advice and show the
package leaflet or the label to the doctor. Swelling of the face, lips or eyes or
difficulty with breathing are more serious symptoms and require urgent medical
attention.
•

The product should not be administered with antibiotics that have a bacteriostatic
mode of action.
Anti-inflammatories such as salicylates, produce an increase in the elimination half-
life of penetamate (iohydrate). In case of joint administration, adjust the dose of the
antibacterial

Revised: July 2020
AN: 01181/2019

Before reconstitution, the powder and solvent vials do not require any special storage
conditions.
The reconstituted suspension should be stored in the refrigerator (2-8°C).

Meat and offal: 4 days
Milk: 2.5 days (60 hours).
5.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.