Oxyfluke 34 mg/ml Oral Suspension for Cattle and Sheep

At normal dose levels, oxyclozanide is not active against immature flukes
present in liver tissue.
Milking cattle, particularly high yielders, may occasionally show a reduction in
yield of 5% or more for about 48 hours after handling. The effect of this small

Unlimited Renewal: March 2022
AN: 02830/2021
loss may be minimised by spreading herd dosing over a period of about a
week.
Care should be taken to avoid the following practices because they increase
the risk of development of resistance and could ultimately result in ineffective
therapy:
Too frequent and repeated use of anthelmintics from the same class, over an
extended period of time.
Underdosing, which may be due to underestimation of body weight,
misadministration of the product or lack of calibration of the dosing device (if
any).
Suspected clinical cases of resistance to anthelmintics should be further
investigates using appropriate tests (e.g. Faecal Egg Count Reduction Test).
Where the results of the test(s) strongly suggest resistance to a particular
anthelmintic, an anthelmintic belonging to another pharmaceutical class and
having a different mode of action should be used.
To date no resistance to oxyclozanide has been reported. Use of the product
should be based on local (regional, farm) epidemiological information about
susceptibility of nematodes and recommendations on how to limit further
selection for resistance to anthelmintics.

Special precautions for use in animals
Care should be taken when administering by dosing gun to avoid damage to
the pharyngeal region.
Due regard must be given to the physical condition of the animals undergoing
treatment, particularly those in advanced pregnancy and / or under stress from
adverse weather conditions, poor nutrition, penning, handling etc.
Special precautions to be taken by the person administering the veterinary
medicinal product to animals
This product can cause irritation to skin, eyes and mucous membranes. In
case of contact, rinse the affected area immediately with plenty of water.
Contaminated clothing should be removed immediately.
Wash hands after use.
Wear impermeable gloves during use.
Do not eat, drink or smoke where handling the product.
People with known hypersensitivity to oxyclozanide or any of the excipients
should avoid contact with the product.
Other precautions
Oxyclozanide may be toxic to dung fauna at high concentrations anticipated in
dung. The possible risk to dung fauna can be reduced by avoiding too
frequent and repeated use of Oxyclozanide in cattle.

Unlimited Renewal: March 2022
AN: 02830/2021