Downland Fluke and Worm Oral Suspension

Care should be taken to avoid the following practices because they increase
the risk of development of resistance and could ultimately result in ineffective
therapy:

Revised: May 2023
AN: 03464/2022
•
extended period of time.
•
misadministration of the product, or lack of calibration of the dosing device
(if any)
Suspected clinical cases of resistance to anthelmintics should be further
investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test).
Where the results of the test(s) strongly suggest resistance to a particular
anthelmintic, an anthelmintic belonging to another pharmacological class and
having a different mode of action should be used.
Resistance to levamisole has been reported in ,
Trichostrongylus
There are reports of resistance in
Resistance to levamisole has been reported in
developed countries such as New Zealand. Therefore the use of this product
should be based on local (regional, farm) epidemiological information about
susceptibility of nematodes and recommendations on how to limit further
selection for resistance to anthelmintics.
To date, no resistance to oxyclosanide has been reported. The use of this
product should be based on local (regional, farm) epidemiological information
about susceptibility of trematodes and recommendations on how to limit further
selection for resistance to anthelmintics.

i Special precautions for use in animals
Care should be taken to estimate accurately the liveweight of animals to be
treated. Animals should not be dosed as per the heaviest animal in the group.
It is important that the container is shaken before use. After treatment, animals
should be moved to clean pasture in order to prevent re-infection. Veterinary
advice should be sought on appropriate dosing programmes and stock
management to achieve adequate parasite control and reduce the likelihood of
anthelmintic resistance developing. Veterinary advice should be sought if the
product does not achieve the desired clinical effect since other diseases,
nutritional disturbances or anthelmintic resistance may be involved.

Revised: May 2023
AN: 03464/2022
ii. Special precautions to be taken by the person administering the

veterinary medicinal product to animals
Do not eat, drink or smoke when using this product. Wash splashes from
eyes and skin immediately. Remove any contaminated clothing immediately.
Wash hands and exposed skin after handling this product, and before
meals. Levamisole can cause idiosyncratic reactions and serious blood
disorders in a very small number of people. If symptoms such as dizziness,
nausea, vomiting or abdominal discomfort are experienced when using this
product, or sore mouth/throat or fever occur shortly afterwards, then medical
advice should be sought immediately.