Combinex Cattle Oral Suspension
Active ingredients: Levamisole Hydrochloride, Triclabendazole
Form
Liquid
Species
Manufacturer
Elanco Europe Ltd
VMD MA No.
00879/5097
What it's used for
For the treatment and control of parasitic bronchitis, parasitic gastro-enteritis and fascioliasis in cattle. When used at the recommended dose rate, the p...
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Prescription required
Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.
Combinex Cattle Oral Suspension — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.
fascioliasis in cattle. When used at the recommended dose rate, the product is
effective against mature and developing immature stages of Levamisole
susceptible
Bunostromum
Dictyocaulus spp
immature and adult
effective against all stages of Triclabendazole susceptible from
Revised: December 2025
MA split from NI Expiry following AN: 03240/2025
two week old early immature to adult fluke, and so is indicated against both acute
and chronic fascioliasis.
drenching gun. Shake container thoroughly before use and use undiluted product
from the original container.
Unscrew the blue cap from the container and replace it with the white spigot cap
provided. If using an automatic drenching-gun, attach the tube from the
application device to the white spigot cap. After use, remove the white spigot cap
and close the container with the blue cap.
Revised: December 2025
MA split from NI Expiry following AN: 03240/2025
It can be safely administered to young or pregnant cattle.
Recommended dose rate: 7.5mg levamisole hydrochloride/kg and 12mg
triclabendazole/kg. This is equivalent to 1ml of the product per 10kg bodyweight.
To ensure administration of correct dose, body weight should be determined as
accurately as possible; accuracy of the dosing device should be checked.
higher dosages, transient side effects due to levamisole may occur (i.e. salivation
and slight muscle tremors).
strains are present. Efficacy of this product against liver fluke is reduced if
triclabendazole resistant strains are present.
Care should be taken to avoid the following practices because they increase the risk
of development of resistance and could ultimately result in ineffective therapy:
•
an extended period of time
•
misadministration of the product or lack of calibration of the dosing device
(if any).
Suspected clinical cases of resistance to anthelmintics should be further investigated
using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where the results of
the test(s) strongly suggest resistance to a particular anthelmintic, an anthelmintic
belonging to another pharmacological class and having a different mode of action
should be used.
Resistance to levamisole has been reported in Teladorsagia species in cattle in
developed countries such as New Zealand. Therefore the use of this product should
be based on local (regional, farm) epidemiological information about susceptibility of
the nematodes and recommendations on how to limit further selection for resistance
to anthelmintics.
i. Special precautions for use in animals
Assess bodyweight as accurately as possible before calculating the dosage.
Clean drenching equipment before and after use.
Intensive use or misuse of anthelmintics can give rise to resistance. To reduce
this risk, dosing programmes should be discussed with your Veterinary
Adviser.
Revised: December 2025
MA split from NI Expiry following AN: 03240/2025
ii. Special precautions to be taken by the person administering the product
When administering, do not eat, drink or smoke.
Wash splashes from eyes and skin immediately.
Immediately remove any contaminated clothing.
Wash hands and exposed skin before meals and after work.
Levamisole can cause idiosyncratic reactions and serious blood disorders in a
very small number of people. If symptoms such as dizziness, nausea,
vomiting or abdominal discomfort are experienced when using the product, or
sore mouth/throat or fever occurs shortly afterwards, then medical advice
should be sought immediately
o
C.
Protect from light. Protect from frost.
Following withdrawal of the dose, use the product within 1 year. Discard unused
material.
compounds.
4.9 Amounts to be administered and administration route
Given as an oral drench. Suitable for use through most types of automatic
drenching gun. Shake container thoroughly before use and use undiluted product
from the original container.
Unscrew the blue cap from the container and replace it with the white spigot cap
provided. If using an automatic drenching-gun, attach the tube from the
application device to the white spigot cap. After use, remove the white spigot cap
and close the container with the blue cap.
Revised: December 2025
MA split from NI Expiry following AN: 03240/2025
It can be safely administered to young or pregnant cattle.
Recommended dose rate: 7.5mg levamisole hydrochloride/kg and 12mg
triclabendazole/kg. This is equivalent to 1ml of the product per 10kg bodyweight.
To ensure administration of correct dose, body weight should be determined as
accurately as possible; accuracy of the dosing device should be checked.
4.10 Overdose (symptoms, emergency procedures, antidotes, if necessary)
At higher doses transient side effects due to levamisole may occur (i.e. salivation
and dose dependent muscle tremors).
4.11 Withdrawal period(s)
Animals must not be slaughtered for human consumption during treatment.
Cattle may be slaughtered for human consumption only after 56 days from the last
treatment.
Not authorised for use in cattle producing milk for human consumption including
during the dry period. Do not use during the last trimester of pregnancy in heifers
which are intended to produce milk for human consumption.
5.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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Other Products Containing Levamisole Hydrochloride
These products share the same active ingredient and may be suitable alternatives. Always consult your vet.
Chanaverm 7.5% Oral Solution
POM-VPSChanelle Pharmaceuticals Manufacturing Ltd
Chanaverm 7.5% Oral Solution
POM-VPSChanelle Pharmaceuticals Manufacturing Ltd
Combinex 50 mg/ml + 37.5 mg/ml Oral Suspension for Sheep
POM-VPSElanco GmbH
Combinex 50 mg/ml + 37.5 mg/ml Oral Suspension for Sheep
POM-VPSElanco GmbH
Downland Fluke and Worm Oral Suspension
POM-VPSNorbrook Laboratories Limited
Levacide 7.5% Solution for Injection for Cattle and Sheep
POM-VPSNorbrook Laboratories Limited
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