Levacide 7.5% Solution for Injection for Cattle and Sheep

Care should be taken to avoid the following practices because they increase
the risk of development of resistance and could ultimately result in ineffective
therapy:
•
an extended period of time.

Revised: July 2010
(ATC vet code amended)
•
misadministration of the product, or lack of calibration of the dosing
device (if any).
Suspected clinical cases of resistance to anthelmintics should be further
investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test).
Where the results of the test(s) strongly suggest resistance to a particular
anthelmintic, an anthelmintic belonging to another pharmacological class and
having a different mode of action should be used.
Resistance to levamisole has been reported in , and
Trichostrongylus species in sheep in a number of countries, including the EU.
There are reports of resistance in in sheep outside the EU.
Resistance to levamisole has been reported in
in developed countries such as New Zealand. Therefore the use of this
product should be based on local (regional, farm) epidemiological information
about susceptibility of nematodes and recommendations on how to limit
further selection for resistance to anthelmintics.
In cases of lungworm infections, coughing may persist for a considerable time
following successful treatment due to tissue damage caused by the parasite.

i. Special precautions for use in animals
Care should be taken to estimate accurately the liveweight of animals to
be treated. After treatment animals should be moved to clean pasture in
order to prevent re-infection.
Veterinary advice should be sought:
a) On appropriate dosing programmes and stock management to achieve
adequate parasite control, and to reduce the likelihood of anthelmintic
resistance developing.
b) If the product does not achieve the desired clinical effect since other
diseases, nutritional disturbances or anthelmintic resistance might be
involved.
ii. Special precautions to be taken by the person administering the veterinary
medicinal product to animals
Do not eat, drink or smoke when using this product. Care should be taken
to avoid accidental self-injection: may cause irritation at site of injection.
Wash splashes from eyes and skin immediately. If irritation persist, seek
medical advice. Remove any contaminated clothing immediately. Wash
hands and exposed skin after handling this product and before meals.
Levamisole can cause idiosyncratic reactions and serious blood disorders
in a very small number of people. If symptoms such as dizziness,
nausea, vomiting or abdominal discomfort are experienced when using

Revised: July 2010
(ATC vet code amended)
this product, or sore mouth, throat or fever occur shortly afterwards, then
medical advice should be sought immediately.