POM-V Prescription Required

Ovarelin 50 µg/ml, Solution for Injection for Cattle

Active ingredient: Gonadorelin

Form

Injection

Species

Cattle

Manufacturer

Ceva Sante Animale

VMD MA No.

14966/3058

What it's used for

Treatment of delayed ovulation (repeat breeding). A repeat breeder cow or heifer is generally defined as an animal that has been inseminated at least 2 or...

Full indications, dosage and side effects ↓

View official SPC (PDF)

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Paying less for Gonadorelin

1

Ask your vet for a written prescription

They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

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The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

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Prescription required

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Clinical information

Ovarelin 50 µg/ml, Solution for Injection for Cattle — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

Treatment of delayed ovulation (repeat breeding).
A repeat breeder cow or heifer is generally defined as an animal that has been
inseminated at least 2 or often 3 times without becoming pregnant, despite having regular
normal oestrus cycles (every 18 -24 days), normal oestrus behaviour and no clinical
abnormalities of the reproductive tract.

100 µg of gonadorelin (as diacetate) per animal in a single injection:i.e. 2 ml of the
veterinary medicinal product per animal.
Judgement on the protocol to be used should be made by the veterinarian responsible for
treatment, on the basis of the treatment objectives of the individual herd or cow. The
following protocols have been evaluated and could be used:
Induction and synchronisation of oestrus and ovulation in combination with a
PGF2α or analogue:
• Day 0: First injection of gonadorelin (2 ml of the veterinary medicinal product).
• Day 7: Injection of PGF2 α or analogue .
• Day 9: Second injection of gonadorelin (2 ml of the veterinary medicinal product) should
be done.
The animal should be inseminated within 16-20 hours after the last injection of the
veterinary medicinal product or at observed oestrus if sooner.
Induction and synchronisation of oestrus and ovulation in combination with a
PGF2α or analogue and a progesterone releasing intravaginal device:
The following FTAI protocols have been commonly reported in the literature:
• Insert progesterone releasing intravaginal device for 7 days.
• Inject gonadorelin (2 ml of the veterinary medicinal product) at the progesterone device
insertion.
• Inject a PGF2 α or analogue 24 hours prior to device removal.
• FTAI 56 hours after removal of the device, or
• Inject gonadorelin (2 ml of the veterinary medicinal product) 36 hours after progesterone
releasing intravaginal device removal and FTAI 16 to 20 hours later.
Treatment of delayed ovulation (repeat-breeding):
GnRH is injected during oestrus.
To improve the pregnancy rates, the following timing of injection and insemination should
be followed:
- injection should be performed between 4 and 10 hours after oestrus detection.
- an interval of at least 2 hours between the injection of GnRH and artificial insemination is
recommended.
- artificial insemination should be carried out in accordance with the usual field
recommendations, i.e., 12 to 24 hours after oestrus detection.

Do not use in cases of hypersensitivity to the active substance or to any of the excipients.

None.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative, or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.

The response of dairy cows to synchronisation protocols may be influenced by the
physiological state at the time of treatment, which includes age of the cow, body condition
and interval from calving.
Responses to treatment are not uniform either across herds or across cows within herds.
Where a period of progesterone treatment is included in the protocol, the percentage of
cows displaying oestrus within a given period is usually greater than in untreated cows and
the subsequent luteal phase is of normal duration.

Special precautions for safe use in the target species
Not applicable.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Gonadorelin is a Gonadotropin Releasing Hormone (GnRH) analogue which stimulates the
release of sex hormones. The effects of accidental exposure to GnRH analogues in
pregnant women or in women with normal reproductive cycles are unknown. The
veterinary medicinal product should not be administered by pregnant women. Women of
child-bearing age should administer the veterinary medicinal product with caution. Care
should be taken when handling the veterinary medicinal product to avoid self-injection. In
cases of accidental self-injection, seek medical advice immediately and show the package
leaflet or the label to the physician.
Care should be taken to avoid skin and eye contact. In cases of skin contact, rinse
immediately and thoroughly with water as GnRH analogues can be absorbed through the
skin. In cases of accidental contact with the eyes, rinse thoroughly with plenty of water.
People with known hypersensitivity (allergy) to GnRH analogues should avoid contact with
the veterinary medicinal product.
Special precautions for the protection of the environment:
Not applicable.

None known.

Do not store above 25°C.
Keep the container in the outer carton in order to protect from light.

Meat and offal: zero days.
Milk: zero hours.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.