Orniflox 25 mg/ml Concentrate for Oral Solution for Pet Rabbits, Rodents, Ornamental Birds and Reptiles

Advice on correct administration
The undiluted veterinary medicinal product is strongly alkaline and, therefore to avoid
caustic effects, it is essential to dilute the product with at least 4 parts water prior to
administration. In the case of smaller animals (weighing less than 500 g), it may be
appropriate to dilute 0.1 ml of the neat product with >4 parts water and administer a
proportion of the total volume.
10 ml bottle: A 1 ml syringe is provided with the 10 ml bottle for withdrawal of small
volumes of the product and to facilitate dilution prior to administration. This syringe
has dosage graduations of 0.01 and 0.1 ml. The lowest volume that has been
demonstrated to be accurate is 0.1 ml. Therefore, for accuracy of dosing, it is
recommended to draw up a minimum of 0.1 ml of product.
50 ml bottle: A 5 ml syringe is provided with the 50 ml bottles for withdrawal of product.
The diluted solution should be mixed thoroughly prior to administration.
Medicated drinking water should be freshly prepared and supplied immediately,
preferably in a glass container, and replaced every 12 hours. Any medicated drinking
water solution not consumed after 12 hours should be disposed of.

Revised: December 2020
AN: 01792/2019
The dilution prepared for direct administration should be made on a twice-daily basis
immediately prior to provision , preferably in a glass container. This dilution should be
administered immediately. Any unused solution should be disposed of immediately
after use.
After extracting and expressing the amount of veterinary medicinal product required
the syringes should be washed with lukewarm water to remove any remaining
product. The syringe can subsequently be used to prepare another solution or be
opened, emptied and left to dry.
Pet rabbits, rodents and reptiles
For administration by oral gavage.
Ornamental birds
For administration via medicated drinking water or by oral gavage (crop needle).
The uptake of medicated water depends on the clinical condition of the animals, the
environment, the age and the kind of feed provided. In order to obtain the correct
dosage, the concentration of enrofloxacin should be adjusted accordingly.
In order to ensure consumption of the medicated water, animals should not have
access to other water supplies whilst being treated.
Dosage
Never administer undiluted product. Ensure thorough mixing.
Owing to physiological and pharmacokinetic differences between the wide range of
species for which this veterinary medicinal product is indicated, the dose rates below
are for guidance only. Depending upon the species of animal and the infection to be
treated, alternative doses may be appropriate using an evidence-based approach.
However, any change in dosing regimen should be based on a benefit-risk
assessment by the responsible veterinarian, as tolerance at higher doses has not
been investigated.
To avoid inhalation of the medication, care should be taken with restraint of the
animal and administration of the veterinary medicinal product.
Rodents and pet rabbits
5 mg enrofloxacin per kg bodyweight (0.2 ml per kg bodyweight), twice daily for 7
days.
Reptiles
5 mg enrofloxacin per kg bodyweight (0.2 ml per kg bodyweight), at 24-48 hour
intervals

for 6 days.
Reptiles are ectothermic, relying on external heat sources to maintain their body
temperature at the optimum level for correct function of all body systems. Metabolism
of substances and activity of the immune system are, thus, critically dependant on
the body temperature. Therefore, the veterinarian must be aware of correct
temperature requirements of the respective reptile species and the hydration status
of the individual patient. Furthermore, it has to be considered that large differences
exist in the pharmacokinetic behaviour of enrofloxacin among different species,
which additionally will influence the decision about the correct dosage of the

Revised: December 2020
AN: 01792/2019
veterinary medicinal product. Therefore, the recommendations made here can only
be used as a starting point for individual dose setting.
Ornamental birds
10 mg enrofloxacin per kg bodyweight (0.4 ml per kg bodyweight), twice daily for
7 days.
Treatment should be re-evaluated if no improvement is seen. It is commonly advised
to re-evaluate the treatment if no clinical improvement is observed within 3 days.