Noropraz, 18.7 mg/g + 140.3 mg/g Oral Paste for Horses

Care should be taken to avoid the following practices because they increase the
risk of development of resistance and could ultimately result in ineffective
therapy:
-Too frequent and repeated use of anthelmintics from the same class, over an
extended period of time.
-Underdosing, which may be due to underestimation of body weight,
misadministration of the product, or lack of calibration of the dosing device.
Suspected clinical cases of resistance to anthelmintics should be further
investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test).
Where the results of the test(s) strongly suggest resistance to a particular
anthelmintic, an anthelmintic belonging to another pharmacological class and
having a different mode of action should be used.
Resistance to ivermectin (an avermectin) has been reported in Parascaris
equorum in horses in a number of countries including in the EU. Therefore the
use of this product should be based on local {regional farm) epidemiological
information about susceptibility of nematodes and recommendations on how to
limit further selection for resistance to anthelmintics. Therefore the use of this
product should be based on local (regional farm) epidemiological information
about susceptibility of nematodes and recommendations on how to limit further
selection for resistance to anthelmintics.
As tapeworm infestation is unlikely to occur in horses before two months of age,
treatment of foals below this age is not considered necessary.

Special precautions for safe use in the target species:
Not applicable.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Wash hands after use.
Do not eat, drink or smoke while handling this product.Avoid contact with the eyes as the product may cause eye irritation.In case of accidental eye contact rinse immediately with plenty of water.In case of accidental ingestion or eye irritation, seek medical advice and show the
package leaflet or the label to the physician.
Special precautions for the protection of the environment:
Not applicable.
Other precautions:
Avermectins may not be well tolerated in all non target animals. Cases of
intolerance are reported in dogs, especially Collies,
Old English Sheepdogs and
related breeds or crosses, and also in turtles and tortoises.
Dogs and cats should not be allowed to ingest spilled paste or access to used
syringes due to the potential for adverse effects related to ivermectin toxicity.