POM-V Prescription Required

Nobilis E.coli inac Emulsion for Injection for Chickens

Active ingredient: Escherichia coli

Form

Injection

Species

Chickens

Manufacturer

Intervet International B.V.

VMD MA No.

06376/5011

What it's used for

Partial passive immunisation of broiler chickens during their first 7 weeks of life by vaccination of the broiler breeders as a help against postnatal coli...

Full indications, dosage and side effects ↓

View official SPC (PDF)

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Paying less for Escherichia coli

1

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2

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Prescription required

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Clinical information

Nobilis E.coli inac Emulsion for Injection for Chickens — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

Partial passive immunisation of broiler chickens during their first 7 weeks of life by
vaccination of the broiler breeders as a help against postnatal colibacillosis (airsac disease
and septicaemia) caused by fimbrial F11-antigen and flagellar FT-antigen containing
Esherichia coli (E.coli).
Onset of immunity: 1 day of age (offspring)
Duration of immunity: 7 weeks (offspring)

Intramuscular or subcutaneous use.
Vaccination scheme:
Two injections of 0.5 ml, with an interval of at least 6 weeks. First vaccination at 6-12
weeks of age, revaccination at 14-18 weeks of age.
Before use allow the vaccine to reach room temperature (15 °C - 25 °C).
Shake well before use.
Use sterile vaccination equipment.

None.

Chickens:
-
Very common
(>1 animal / 10 animals treated):
Injection site granuloma
Common
(1 to 10 animals / 100 animals treated):
Injection site necrosis
, injection site abscess
1
Five weeks after vaccination these local reactions are considerably decreased.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or the national competent authority via the
national reporting system. See also the last section of the package leaflet for contact
details.

Vaccinate healthy animals only.

Revised: December 2024
AN: 01646/2024

Special precautions for use in animals
Not applicable.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
To the user:
This veterinary medicinal product contains mineral oil. Accidental injection/self-injection
may result in severe pain and swelling, particularly if injected into a joint or finger, and in
rare cases could result in the loss of the affected finger if prompt medical attention is not
given. If you are accidentally injected with this veterinary medicinal product, seek prompt
medical advice even if only a very small amount is injected and take the package leaflet
with you. If pain persists for more than 12 hours after medical examination, seek medical
advice again.
To the physician:
This veterinary medicinal product contains mineral oil. Even if small amounts have been
injected, accidental injection with this veterinary medicinal product can cause intense
swelling, which may, for example, result in ischaemic necrosis and even the loss of a digit.
Expert, PROMPT, surgical attention is required and may necessitate early incision and
irrigation of the injected area, especially where there is involvement of finger pulp or
tendon.
Special precautions for the protection of the environment:
Not applicable.

Data are available which demonstrate that this vaccine can be administered on the same
day but not mixed with other inactivated vaccines of the same company against avian
infectious bronchitis, avian infectious bursitis, avian tenosynovitis and Newcastle disease.
The vaccine should be given at different.
No information is available on the safety and efficacy of this vaccine when used with any
other veterinary medicinal product except the products mentioned above.A decision to
use this vaccine before or after any other veterinary medicinal product therefore needs to
be made on a case by case basis.

Store in a refrigerator (2C - 8C).
Do not freeze.
Protect from light.

Meat and offal: 35 days.
Eggs: zero days.
5. IMMUNOLOGICAL PROPERTIES
Pharmacotherapeutic group: Immunological for Aves, inactivated bacterial vaccines for
domestic fowls, Escherichia
ATCvet code: QI01AB05
The E.coli antigens are incorporated in a water in oil emulsion in order to enhance and
prolong the production of antibodies against E. coli fimbrial antigen and E coli flagellar
toxin antigen.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.