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POM-V Prescription Required Companion Animal

NexGard 136 mg Chewable Tablets for Dogs >25-50 kg

Active ingredient: Afoxolaner

Form

Chewable

Species

Dogs

Manufacturer

Boehringer Ingelheim Vetmedica GmbH

VMD MA No.

61700/5031

What it's used for

veterinary medicinal product provides immediate and persistent killing activity for at least 5 weeks. For reduction of the risk of infection with Dipylidiu...

Full indications, dosage and side effects ↓
View official SPC (PDF)

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Paying less for Afoxolaner

  1. 1

    Ask your vet for a written prescription

    They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.

  2. 2

    Fill it at a registered online retailer

    The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

NexGard 136 mg Chewable Tablets for Dogs >25-50 kg — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

veterinary medicinal product provides immediate and persistent killing activity for at
least 5 weeks.
For reduction of the risk of infection with Dipylidium caninum via transmission by
Ctenocephalides felis for 30 days. The effect is indirect due to the activity of the
veterinary medicinal product against the vector.
The product can be used as part of a treatment strategy for the control of flea allergy
dermatitis (FAD).
Treatment of tick infestation in dogs (Dermacentor reticulatus, , Ixodes
hexagonus, Rhipicephalus sanguineus, Hyalomma marginatum). The veterinary
medicinal product provides immediate and persistent killing activity for one month.
For reduction of the risk of infection with Babesia canis via transmission by
Dermacentor reticulatus for 28 days. The effect is indirect due to the activity of the
veterinary medicinal product against the vector.
Fleas and ticks must attach to the host and commence feeding in order to be
exposed to the active substance.
Treatment of demodicosis (caused by Demodex canis).
Treatment of sarcoptic mange (caused by Sarcoptes scabiei var. canis).
Treatment of ear mite infestations (caused by Otodectes cynotis).
Dosage:
The veterinary medicinal product should be administered at a dose of 2.7 to 7 mg/kg
bodyweight of afoxolaner in accordance with the following table:
Strength and number of chewable tablets to be administeredBodyweight
of dog (kg)
NexGard
11 mg
NexGard
28 mg
NexGard
68 mg
NexGard
136 mg
2–41> 4–101> 10–251> 25–501
For dogs above 50 kg bodyweight, use an appropriate combination of chewable
tablets of different/same strengths.
To ensure a correct dosage, body weight should be determined as accurately as
possible.
The chewable tablets should not be divided. Underdosing could result in ineffective
use and may favour resistance development.
Method of administration:
The tablets are chewable and palatable to most dogs. If the dog does not accept the
tablets directly they may be administered with food.
Treatment schedule:
Treatment of flea and tick infestations:
Monthly intervals throughout the flea and/or tick seasons, based on local
epidemiological situations and the animal’s lifestyle.
Treatment of demodicosis (caused by Demodex canis):
Administration of the veterinary medicinal product leads to a marked improvement of
clinical signs. Treatment should be continued until two negative skin scrapings are
obtained one month apart. Severe cases may require prolonged monthly treatments.
As demodicosis is a multi-factorial disease, where possible, it is advisable to also
treat any underlying disease appropriately.
Treatment of sarcoptic mange (caused by Sarcoptes scabiei var. canis):

Amended pages: January 2026
Monthly administration of the veterinary medicinal product for two consecutive
months. Further monthly administration may be required based on clinical
assessment and skin scrapings.
Treatment of ear mite infestations Otodectes cynotis):
A single dose of the veterinary medicinal product should be administered. A further
veterinary examination one month after the initial treatment is recommended as
some animals may require a second treatment.
Do not use in cases of hypersensitivity to the active substance or to any of the
excipients.
Dogs:
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Digestive tract disorders
(vomiting
,
diarrhoea
)
Lethargy
, anorexia
Pruritus
Neurological disorders (convulsion
,
ataxia
, muscle tremor
).
Mild.
Mostly self-limiting and of short duration.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.
Parasites need to start feeding on the host to become exposed to afoxolaner;
therefore the risk of the transmission of parasite borne diseases cannot be excluded.
Unnecessary use of antiparasitics or use deviating from the instructions given in the
SPC may increase the resistance selection pressure and lead to reduced efficacy.
The decision to use the product should be based on confirmation of the parasitic
species and burden, or of the risk of infestation based on its epidemiological features,
for each individual animal.
The possibility that other animals in the same household can be a source of re-
infestation with fleas, ticks or mites should be considered, and these should be
treated as necessary with an appropriate product.

Amended pages: January 2026

Special precautions for safe use in the target species:
In the absence of available data, treatment of puppies less than 8 weeks of age
and/or dogs less than 2 kg bodyweight should be based on a benefit-risk assessment
by the responsible veterinarian.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
To prevent children from getting access to the veterinary medicinal product, remove
only one chewable tablet at a time from the blister. Return the blister with the
remaining chewable tablets into the carton. In case of accidental ingestion, seek
medical advice and show the package leaflet or the label to the physician.
Wash hands after handling the veterinary medicinal product.
Special precautions for the protection of the environment
Not applicable.
None known.
This veterinary medicinal product does not require any special storage conditions.
Not applicable.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.

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