POM-V
Prescription Required
Companion Animal
Moxiclear 40 mg + 4 mg Spot-on Solution for Small Cats and Ferrets
Active ingredients: Imidacloprid, Moxidectin
Form
Spot-on
Species
Cats
Ferrets
Manufacturer
Norbrook Laboratories Limited
VMD MA No.
02000/4435
What it's used for
AN: 01494/2024 & 02361/2024 For ferrets suffering from, or at risk from, mixed parasitic infections: • For the treatment and prevention of flea infestation...
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Clinical information
Moxiclear 40 mg + 4 mg Spot-on Solution for Small Cats and Ferrets — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.
AN: 01494/2024 & 02361/2024
For ferrets suffering from, or at risk from, mixed parasitic infections:
•
For the treatment and prevention of flea infestation (
•
the prevention of heartworm disease (L3 and L4 larvae of
For ferrets suffering from, or at risk from, mixed parasitic infections:
•
For the treatment and prevention of flea infestation (
•
the prevention of heartworm disease (L3 and L4 larvae of
Dosage schedule for cats:
The recommended minimum doses are 10 mg/kg bodyweight imidacloprid and 1.0
mg/kg bodyweight moxidectin, equivalent to 0.1 ml/kg bodyweight of veterinary
medicinal product.
To ensure a correct dosage, body weight should be determined as accurately as
possible.
The treatment schedule should be based on individual veterinary diagnosis and on the
local epidemiological situation.
Weight of cat
Pipette size to be
used
Volume
Imidacloprid
[mg/kg bw]
Moxidectin
[mg/kg bw]
≤ 4 kg
Veterinary medicinal
product for small cats
0.4 mlminimum of 10minimum of 1
> 4 ≤ 8 kg
Veterinary medicinal
product for large cats
0.8 ml10–201–2
> 8 kgthe appropriate combination of pipettes
Flea treatment and prevention (Ctenocephalides felis)
One treatment prevents future flea infestation for 4 weeks. Existing pupae in the
environment may emerge for 6 weeks or longer after treatment is initiated, depending
upon climatic conditions. Therefore, it may be necessary to combine treatment of the
veterinary medicinal product with environmental treatments aimed at breaking the flea
life cycle in the surroundings. This can result in a more rapid reduction in the household
flea population. The veterinary medicinal product should be administered at monthly
intervals when used as part of a treatment strategy for flea allergy dermatitis.
Treatment of ear mite infestation (Otodectes cynotis)
A single dose of the veterinary medicinal product should be administered. A further
veterinary examination 30 days after treatment is recommended as some animals may
require a second treatment. Do not apply directly to the ear canal.
AN: 01494/2024 & 02361/2024
Treatment of notoedric mange (Notoedres cati)
A single dose of the veterinary medicinal product should be administered.
Heartworm prevention (Dirofilaria immitis)
Cats in areas endemic for heartworm, or those which have travelled to endemic areas,
may be infected with adult heartworms. Therefore prior to treatment with the veterinary
medicinal product, the advice provided in section 3.5 should be considered.
For prevention of heartworm disease, the veterinary medicinal product must be applied
at regular monthly intervals during the time of the year when mosquitoes (the
intermediate hosts which carry and transmit heartworm larvae) are present. The
veterinary medicinal product may be administered throughout the year or at least 1
month before the first expected exposure to mosquitoes. Treatment should continue at
regular monthly intervals until 1 month after the last exposure to mosquitoes. To
establish a treatment routine, it is recommended that the same day or date be used
each month. When replacing another heartworm preventative product in a heartworm
prevention programme, the first treatment with the veterinary medicinal product must
be given within 1 month of the last dose of the former medication.
In non-endemic areas there should be no risk of cats having heartworm. Therefore,
they can be treated without special precautions.
Roundworm and hookworm treatment (Toxocara cati and Ancylostoma tubaeforme)
In areas endemic for heartworm, monthly treatment may significantly reduce the risk
of re-infection caused by the respective roundworms and hookworms. In areas non-
endemic for heartworm, the veterinary medicinal product can be used as part of a
seasonal prevention programme against fleas and gastrointestinal nematodes.
Dosage schedule for ferrets:
One pipette of the veterinary medicinal spot-on product should be administered per
animal. Do not exceed the recommended dose.
The treatment schedule should be based on the local epidemiological situation.
Flea treatment and prevention
One treatment prevents future flea infestation for 3 weeks. Under heavy flea pressure
it may be necessary to repeat administration after 2 weeks.
Heartworm prevention
Ferrets in areas endemic for heartworm, or those which have travelled to endemic
areas, may be infected with adult heartworms. Therefore prior to treatment with the
veterinary medicinal product, the advice provided in section 3.5 should be considered.
For prevention of heartworm disease, the veterinary medicinal product must be applied
at regular monthly intervals during the time of the year when mosquitoes (the
intermediate hosts which carry and transmit heartworm larvae) are present. The
veterinary medicinal product may be administered throughout the year or at least 1
AN: 01494/2024 & 02361/2024
month before the first expected exposure to mosquitoes. Treatment should continue at
regular monthly intervals until 1 month after the last exposure to mosquitoes.
In non-endemic areas there should be no risk of ferrets having heartworm. Therefore,
they can be
treated without special precautions.
Method of administration
For external use only. Do not remove the pipette from the sachet until ready to use.
Remove the pipette from the outer sachet using scissors or fold along diagonal line to
expose nick; tear back at nick.
Hold the pipette upright. Tap the narrow part of the pipette to ensure the contents
remain within the main body of the pipette. Twist or snap back the tip.
Part the coat on the back of the animal at the base of the neck in front of the shoulder
blades until the skin is visible. Place the tip of the pipette on the skin and squeeze the
pipette several times to empty its contents completely and directly onto the skin in
one spot. Application at the base of the skull will minimise the opportunity for the
animal to lick the veterinary medicinal product. Apply only to undamaged skin.
AN: 01494/2024 & 02361/2024
The recommended minimum doses are 10 mg/kg bodyweight imidacloprid and 1.0
mg/kg bodyweight moxidectin, equivalent to 0.1 ml/kg bodyweight of veterinary
medicinal product.
To ensure a correct dosage, body weight should be determined as accurately as
possible.
The treatment schedule should be based on individual veterinary diagnosis and on the
local epidemiological situation.
Weight of cat
Pipette size to be
used
Volume
Imidacloprid
[mg/kg bw]
Moxidectin
[mg/kg bw]
≤ 4 kg
Veterinary medicinal
product for small cats
0.4 mlminimum of 10minimum of 1
> 4 ≤ 8 kg
Veterinary medicinal
product for large cats
0.8 ml10–201–2
> 8 kgthe appropriate combination of pipettes
Flea treatment and prevention (Ctenocephalides felis)
One treatment prevents future flea infestation for 4 weeks. Existing pupae in the
environment may emerge for 6 weeks or longer after treatment is initiated, depending
upon climatic conditions. Therefore, it may be necessary to combine treatment of the
veterinary medicinal product with environmental treatments aimed at breaking the flea
life cycle in the surroundings. This can result in a more rapid reduction in the household
flea population. The veterinary medicinal product should be administered at monthly
intervals when used as part of a treatment strategy for flea allergy dermatitis.
Treatment of ear mite infestation (Otodectes cynotis)
A single dose of the veterinary medicinal product should be administered. A further
veterinary examination 30 days after treatment is recommended as some animals may
require a second treatment. Do not apply directly to the ear canal.
AN: 01494/2024 & 02361/2024
Treatment of notoedric mange (Notoedres cati)
A single dose of the veterinary medicinal product should be administered.
Heartworm prevention (Dirofilaria immitis)
Cats in areas endemic for heartworm, or those which have travelled to endemic areas,
may be infected with adult heartworms. Therefore prior to treatment with the veterinary
medicinal product, the advice provided in section 3.5 should be considered.
For prevention of heartworm disease, the veterinary medicinal product must be applied
at regular monthly intervals during the time of the year when mosquitoes (the
intermediate hosts which carry and transmit heartworm larvae) are present. The
veterinary medicinal product may be administered throughout the year or at least 1
month before the first expected exposure to mosquitoes. Treatment should continue at
regular monthly intervals until 1 month after the last exposure to mosquitoes. To
establish a treatment routine, it is recommended that the same day or date be used
each month. When replacing another heartworm preventative product in a heartworm
prevention programme, the first treatment with the veterinary medicinal product must
be given within 1 month of the last dose of the former medication.
In non-endemic areas there should be no risk of cats having heartworm. Therefore,
they can be treated without special precautions.
Roundworm and hookworm treatment (Toxocara cati and Ancylostoma tubaeforme)
In areas endemic for heartworm, monthly treatment may significantly reduce the risk
of re-infection caused by the respective roundworms and hookworms. In areas non-
endemic for heartworm, the veterinary medicinal product can be used as part of a
seasonal prevention programme against fleas and gastrointestinal nematodes.
Dosage schedule for ferrets:
One pipette of the veterinary medicinal spot-on product should be administered per
animal. Do not exceed the recommended dose.
The treatment schedule should be based on the local epidemiological situation.
Flea treatment and prevention
One treatment prevents future flea infestation for 3 weeks. Under heavy flea pressure
it may be necessary to repeat administration after 2 weeks.
Heartworm prevention
Ferrets in areas endemic for heartworm, or those which have travelled to endemic
areas, may be infected with adult heartworms. Therefore prior to treatment with the
veterinary medicinal product, the advice provided in section 3.5 should be considered.
For prevention of heartworm disease, the veterinary medicinal product must be applied
at regular monthly intervals during the time of the year when mosquitoes (the
intermediate hosts which carry and transmit heartworm larvae) are present. The
veterinary medicinal product may be administered throughout the year or at least 1
AN: 01494/2024 & 02361/2024
month before the first expected exposure to mosquitoes. Treatment should continue at
regular monthly intervals until 1 month after the last exposure to mosquitoes.
In non-endemic areas there should be no risk of ferrets having heartworm. Therefore,
they can be
treated without special precautions.
Method of administration
For external use only. Do not remove the pipette from the sachet until ready to use.
Remove the pipette from the outer sachet using scissors or fold along diagonal line to
expose nick; tear back at nick.
Hold the pipette upright. Tap the narrow part of the pipette to ensure the contents
remain within the main body of the pipette. Twist or snap back the tip.
Part the coat on the back of the animal at the base of the neck in front of the shoulder
blades until the skin is visible. Place the tip of the pipette on the skin and squeeze the
pipette several times to empty its contents completely and directly onto the skin in
one spot. Application at the base of the skull will minimise the opportunity for the
animal to lick the veterinary medicinal product. Apply only to undamaged skin.
AN: 01494/2024 & 02361/2024
Do not use in kittens under 9 weeks of age.
Do not use in cases of hypersensitivity to the active substances or to any of the
excipients.
For ferrets: Do not use the corresponding veterinary medicinal product for large cats
(0.8 ml) or the corresponding veterinary medicinal product for dogs (any size).
For dogs, the corresponding veterinary medicinal product for dogs, which contains 100
mg/ml imidacloprid and 25 mg/ml moxidectin, must be used.
Do not use on canaries.
Do not use in cases of hypersensitivity to the active substances or to any of the
excipients.
For ferrets: Do not use the corresponding veterinary medicinal product for large cats
(0.8 ml) or the corresponding veterinary medicinal product for dogs (any size).
For dogs, the corresponding veterinary medicinal product for dogs, which contains 100
mg/ml imidacloprid and 25 mg/ml moxidectin, must be used.
Do not use on canaries.
Target Species: Cats, Ferrets.
Rare
(1 to 10 animals / 10,000 animals
treated):
Application site greasy fur
,
Erythema
,
Vomiting
Hypersensitivity reaction (local)
Very rare
(<1 animal / 10,000 animals treated,
including isolated reports):
Pruritus
Neurological signs
,
Hypersalivation
,
Behavioural disorders (e.g. ,
agitation)
, Lethargy
, Inappetence
1
Disappears without further treatment.
In cats. Transient.
If the animal licks the application site after treatment. Mostly transient.
If the animal licks the application site immediately after treatment. Not a sign of
intoxication; disappears within minutes. Correct application will minimise licking of the
application site.
Caused by a sensation at the application site.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.
Rare
(1 to 10 animals / 10,000 animals
treated):
Application site greasy fur
,
Erythema
,
Vomiting
Hypersensitivity reaction (local)
Very rare
(<1 animal / 10,000 animals treated,
including isolated reports):
Pruritus
Neurological signs
,
Hypersalivation
,
Behavioural disorders (e.g. ,
agitation)
, Lethargy
, Inappetence
1
Disappears without further treatment.
In cats. Transient.
If the animal licks the application site after treatment. Mostly transient.
If the animal licks the application site immediately after treatment. Not a sign of
intoxication; disappears within minutes. Correct application will minimise licking of the
application site.
Caused by a sensation at the application site.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.
The veterinary medicinal product’s efficacy has not been tested in ferrets weighing over
2 kg and therefore the duration of effect might be shorter in these animals.
Brief contact of the animal with water on one or two occasions between monthly
treatments is unlikely to significantly reduce the efficacy of the veterinary medicinal
product. However, frequent shampooing or immersion of the animal in water after
treatment may reduce the efficacy of the veterinary medicinal product.
Parasite resistance to any particular class of anthelmintic may develop following
frequent, repeated use of an anthelmintic of that class. Therefore, the use of this
veterinary medicinal product should be based on the assessment of each individual
case and on local epidemiological information about the current susceptibility of the
target species in order to limit the possibility of a future selection for resistance.
The use of the veterinary medicinal product should be based on the confirmed
diagnosis of mixed infection (or risk of infection, where prevention applies) at the same
time (see also sections 3.2 and 3.9).
Special precautions for safe use in the target species:
The treatment of cats weighing less than 1 kg and ferrets weighing less than 0.8 kg
should be based on a risk-benefit assessment.
There is limited experience on the use of the veterinary medicinal product in sick and
debilitated animals, thus the veterinary medicinal product should only be used based
on a risk-benefit assessment for these animals.
Care should be taken that the content of the pipette or the applied dose does not come
into contact with the eyes or mouth of the recipient and/or other animals.
AN: 01494/2024 & 02361/2024
Do not allow recently treated animals to groom each other. Oral uptake by Collies, Old
English Sheepdogs and related breeds or crossbreeds should be prevented.
It is recommended that cats and ferrets living in, or travelling to areas endemic for
heartworm are treated monthly with the veterinary medicinal product to protect them
from heartworm disease.
Whilst the accuracy of diagnosis of heartworm infection is limited, it is recommended
that attempts be made to check the heartworm status of any cat and ferret aged over
6 months, before beginning prophylactic treatment, as use of the veterinary medicinal
product on cats or ferrets which have adult heartworms may cause serious adverse
effects, including death. If adult heartworm infection is diagnosed, the infection should
be treated in accordance with current scientific knowledge.
In certain individual cats
cases concomitant supportive treatment is necessary as treatment with the veterinary
medicinal product alone may not be sufficient to prevent death of the animal.
Imidacloprid is toxic for birds, especially canaries.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
Avoid contact with skin, eyes or mouth.
Do not eat, drink or smoke during application.
Wash hands thoroughly after use.
If the veterinary medicinal product accidentally gets into eyes, they should be
thoroughly flushed with water.
In case of accidental spillage onto skin, wash off immediately with soap and water.
If skin or eye symptoms persist, or the veterinary medicinal product is accidentally
swallowed, seek medical advice immediately and show the package leaflet or the label
to the physician.
Do not ingest. In case of accidental ingestion, seek medical advice immediately and
show the package leaflet or the label to the physician.
People with known hypersensitivity to benzyl alcohol, imidacloprid or moxidectin
should administer the veterinary medicinal product with caution.
In very rare cases the veterinary medicinal product may cause skin sensitisation or
transient skin reactions (for example numbness, irritation or burning/tingling
sensation).
In very rare cases the veterinary medicinal product may cause respiratory irritation in
sensitive individuals.
In order to prevent children from getting access to pipettes, keep the pipette in the
original packaging until ready for use and dispose of used pipettes immediately.
After application do not stroke or groom animals until the application site is dry.
Treated animals should not be handled until the application site is dry, and children
should not be allowed to play with treated animals until the application site is dry. It is
therefore recommended that animals are not treated during the day, but should be
treated during the early evening, and that recently treated animals are not allowed to
sleep with owners, especially children.
AN: 01494/2024 & 02361/2024
Special precautions for the protection of the environment:
Not applicable.
Other precautions:
The solvent in the veterinary medicinal product may stain or damage certain materials
including leather, fabrics, plastics and finished surfaces. Allow the application site to
dry before permitting contact with such materials.
2 kg and therefore the duration of effect might be shorter in these animals.
Brief contact of the animal with water on one or two occasions between monthly
treatments is unlikely to significantly reduce the efficacy of the veterinary medicinal
product. However, frequent shampooing or immersion of the animal in water after
treatment may reduce the efficacy of the veterinary medicinal product.
Parasite resistance to any particular class of anthelmintic may develop following
frequent, repeated use of an anthelmintic of that class. Therefore, the use of this
veterinary medicinal product should be based on the assessment of each individual
case and on local epidemiological information about the current susceptibility of the
target species in order to limit the possibility of a future selection for resistance.
The use of the veterinary medicinal product should be based on the confirmed
diagnosis of mixed infection (or risk of infection, where prevention applies) at the same
time (see also sections 3.2 and 3.9).
Special precautions for safe use in the target species:
The treatment of cats weighing less than 1 kg and ferrets weighing less than 0.8 kg
should be based on a risk-benefit assessment.
There is limited experience on the use of the veterinary medicinal product in sick and
debilitated animals, thus the veterinary medicinal product should only be used based
on a risk-benefit assessment for these animals.
Care should be taken that the content of the pipette or the applied dose does not come
into contact with the eyes or mouth of the recipient and/or other animals.
AN: 01494/2024 & 02361/2024
Do not allow recently treated animals to groom each other. Oral uptake by Collies, Old
English Sheepdogs and related breeds or crossbreeds should be prevented.
It is recommended that cats and ferrets living in, or travelling to areas endemic for
heartworm are treated monthly with the veterinary medicinal product to protect them
from heartworm disease.
Whilst the accuracy of diagnosis of heartworm infection is limited, it is recommended
that attempts be made to check the heartworm status of any cat and ferret aged over
6 months, before beginning prophylactic treatment, as use of the veterinary medicinal
product on cats or ferrets which have adult heartworms may cause serious adverse
effects, including death. If adult heartworm infection is diagnosed, the infection should
be treated in accordance with current scientific knowledge.
In certain individual cats
cases concomitant supportive treatment is necessary as treatment with the veterinary
medicinal product alone may not be sufficient to prevent death of the animal.
Imidacloprid is toxic for birds, especially canaries.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
Avoid contact with skin, eyes or mouth.
Do not eat, drink or smoke during application.
Wash hands thoroughly after use.
If the veterinary medicinal product accidentally gets into eyes, they should be
thoroughly flushed with water.
In case of accidental spillage onto skin, wash off immediately with soap and water.
If skin or eye symptoms persist, or the veterinary medicinal product is accidentally
swallowed, seek medical advice immediately and show the package leaflet or the label
to the physician.
Do not ingest. In case of accidental ingestion, seek medical advice immediately and
show the package leaflet or the label to the physician.
People with known hypersensitivity to benzyl alcohol, imidacloprid or moxidectin
should administer the veterinary medicinal product with caution.
In very rare cases the veterinary medicinal product may cause skin sensitisation or
transient skin reactions (for example numbness, irritation or burning/tingling
sensation).
In very rare cases the veterinary medicinal product may cause respiratory irritation in
sensitive individuals.
In order to prevent children from getting access to pipettes, keep the pipette in the
original packaging until ready for use and dispose of used pipettes immediately.
After application do not stroke or groom animals until the application site is dry.
Treated animals should not be handled until the application site is dry, and children
should not be allowed to play with treated animals until the application site is dry. It is
therefore recommended that animals are not treated during the day, but should be
treated during the early evening, and that recently treated animals are not allowed to
sleep with owners, especially children.
AN: 01494/2024 & 02361/2024
Special precautions for the protection of the environment:
Not applicable.
Other precautions:
The solvent in the veterinary medicinal product may stain or damage certain materials
including leather, fabrics, plastics and finished surfaces. Allow the application site to
dry before permitting contact with such materials.
During treatment with the veterinary medicinal product no other antiparasitic
macrocyclic lactone should be administered. No interactions between the veterinary
medicinal product and routinely used veterinary medicinal products or medical or
surgical procedures have been observed.
macrocyclic lactone should be administered. No interactions between the veterinary
medicinal product and routinely used veterinary medicinal products or medical or
surgical procedures have been observed.
Do not store above 25 °C.
Store in the original package in order to protect from light and moisture.
Store in the original package in order to protect from light and moisture.
Not applicable.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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