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POM-V Prescription Required Companion Animal

Marbotis 3mg/ml + 10mg/ml + 1mg/ml Ear Drops, Suspension for Dogs

Active ingredients: Clotrimazole, Dexamethasone, Dexamethasone Acetate, Marbofloxacin

Form

Drops

Species

Dogs

Manufacturer

Vet-Agro Multi-Trade Company Sp. z o.o.

VMD MA No.

55788/3000

What it's used for

Treatment of otitis externa of both bacterial and fungal origin respectively due to bacteria sensitive to marbofloxacin, and fungi especially Malassezia pa...

Full indications, dosage and side effects ↓
View official SPC (PDF)

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Prescription required

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Clinical information

Marbotis 3mg/ml + 10mg/ml + 1mg/ml Ear Drops, Suspension for Dogs — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

Treatment of otitis externa of both bacterial and fungal origin respectively due to
bacteria sensitive to marbofloxacin, and fungi especially Malassezia pachydermatis
sensitive to clotrimazole.
For auricular use.
Apply ten drops into the ear once daily for 7 to 14 days.
After 7 days of treatment, the veterinary surgeon should evaluate the necessity to
extend the treatment another week.
One drop of the preparation contains 71 µg marbofloxacin, 237 µg clotrimazole and
23.7 µg dexamethasone acetate.
The external ear canal should be meticulously cleaned and dried before treatment.
Shake well for 30 seconds before use and squeeze gently to fill the dropper with the
veterinary medicinal product.
After application, the base of the ear may be massaged briefly and gently to allow the
preparation to penetrate to the lower part of the ear canal.
When the veterinary medicinal product is intended for use in several dogs, use one
dropper per dog.
Do not use in dogs suffering from perforation of the tympanic membrane.
Do not use in cases of hypersensitivity to the active substances, to other azole
antifungal agents or to any other fluoroquinolones or to any of the excipients.
Do not use in animals, where resistance of causative agents to marbofloxacin and/or
clotrimazole is known.
See section 4.7.
Dogs:
Rare
(1 to 10 animals / 10,000
animals treated):
Deafness
Undetermined frequency
(cannot be estimated from the
available data):
Changes in biochemical and haematological
parameters (e.g., Elevated serum alkaline
phosphatase (ALP), Elevated alanine
aminotransferase (ALT)/Elevated aspartate
aminotransferase (AST), Neutrophilia)
1
Mainly in elderly dogs and mostly of a transient nature.
Associated with corticosteroid drugs.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See also section 16 of the
package leaflet for contact details.
Bacterial and fungal otitis is often secondary in nature. The underlying cause should
be identified and treated.

Revised: October 2024
AN: 02182 2023

Special precautions for use in animals
Before treating with the veterinary medicinal product, the integrity of the tympanic
membrane must be verified.
Use of the veterinary medicinal product should be based on susceptibility testing of
the bacteria and/or fungi isolated from the animal. If this is not possible, therapy
should be based on local (regional) epidemiological information about susceptibility
of the target pathogens.
Official and local antimicrobial policies should be taken in to account when the
veterinary medicinal product is used.
Heavy reliance on a single class of antibiotic may result in the induction of resistance
in a bacterial population.
It is prudent to reserve the fluoroquinolones for the treatment of clinical conditions
which have responded poorly, or are expected to respond poorly, to other classes of
antibiotics.
Quinolone class drugs have been associated with cartilage erosions in weight-
bearing joints and other forms of arthropathy in immature animals of various species.
The use of the product in young animals is not recommended.
Prolonged and intensive use of topical corticosteroid preparations is known to trigger
local and systemic effects, including suppression of adrenal function, thinning of the
epidermis and delayed wound healing.
Avoid contact with eyes in animals. In case of accidental contact, rinse thoroughly
with water.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
People with known hypersensitivity (allergy) to (fluoro)quinolones, (cortico)steroids or
antifungals and to other ingredients in the veterinary medicinal product should take
care to avoid contact with the veterinary medicinal product during administration.
Avoid contact of the skin and eyes with the veterinary medicinal product. In case of
accidental spillage onto skin or eyes, rinse the affected area with large amounts of
water.
Take care to avoid accidental ingestion. In case of accidental ingestion, seek medical
advice immediately and show the leaflet or the label to the physician.
Wash hands after use.
Special precautions for the protection of the environment:
Not applicable.
Other precautions:
Not applicable.

Revised: October 2024
AN: 02182 2023
None known.
Do not store above 30 C.
Keep the bottles in the outer carton in order to protect from light.
Not applicable.
5.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.

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