Leventa 1 mg/ml Oral Solution for Dogs

In thyroid hormone replacement therapy with L-thyroxine, the dose rate and
regime have to be tailored individually to each dog. A starting dose rate of
20 microgram L-thyroxine sodium/kg once daily is recommended; this
corresponds to 0.2 ml of the veterinary medicinal product per 10 kg bodyweight.
At re-examination four weeks later, dose adjustment should be performed based
on the clinical response to treatment and thyroid hormone concentration
evaluated 4-6 hours after administration of the veterinary medicinal product.
Further assessment of hormonal responses and dose adjustment may be
repeated at 4 week intervals if required.
A maintenance dose rate between 10 and 40 microgram/kg body weight once
daily is generally sufficient to control the clinical signs of hypothyroidism and to
restore thyroid hormone concentrations to within the reference range. Depending
on the dose rate determined as suitable for the dog and on its body weight, the
volume (in ml) of the veterinary medicinal product to be administered once daily
can be estimated using the following table:
Dosage (microgram/kg)10203040
Body
weight
(kg)
Volume of the veterinary medicinal
product (ml)
50.050.100.150.20100.100.200.300.40150.150.300.450.60200.200.400.600.80250.250.500.751.00300.300.600.901.20350.350.701.051.40400.400.801.201.60450.450.901.351.80500.501.001.502.00
The dose for dogs weighing more than 50 kg should be calculated according to
bodyweight in the same way.
Once a suitable dose rate and regime have been established, it is recommended
to recheck every 6 months that thyroid hormone concentrations are appropriate.
The improvement in clinical signs occurs differentially following the onset of
treatment with L-thyroxine: whilst metabolic signs improve within two weeks after
the onset of treatment, dermatological signs may require 6 weeks or more of
treatment before improvement is seen.
The veterinary medicinal product should be administered at the same time every
day. The absorption of L-thyroxine is influenced by food. In order to achieve
consistent absorption of L-thyroxine, it is recommended to administer L-
thyroxine 2 – 3 hours prior to feeding, which will maximise the degree of
absorption and minimize variation in absorption (see also section 4.3).
If L-thyroxine is administered less than 2 hours before feeding, at or after feeding,
the feed given (type and amount) should be standardized.
Instruction for use of the oral syringe:
Open the bottle. Attach the dosing syringe to the bottle by gently pushing the end
of the syringe onto the insert in the bottle. Turn the bottle/syringe upside down
and draw the solution into the syringe by pulling the plunger out until the edge of
the ring on the end of the plunger coincides with the expected volume or body
weight in kilograms. Turn the bottle/syringe right way up and remove the syringe
from the insert. After administering the veterinary medicinal product, clean the
syringe by flushing with clean water and allow to dry naturally.