Levacide Low Volume 7.5% Oral Solution

Care should be taken to avoid the following practices because they
increase the risk of development of resistance and could ultimately
result in ineffective therapy:
•
class, over an extended period of time
•
weight, misadministration of the product, or lack of calibration of
the dosing device (if any)
Suspected clinical cases of resistance to anthelmintics should be
further investigated using appropriate tests (e.g. Faecal Egg Count
Reduction Test). Where the results of the test(s) strongly suggest
resistance to a particular anthelmintic, an anthelmintic belonging to
another pharmacological class and having a different mode of action
should be used.
Resistance to levamisole has been reported in Teladorsagia,
and Trichostrongylus species in sheep in a number of countries,
including the EU. There are reports of resistance in Haemonchus in
sheep outside the EU. Resistance to levamisole has been reported in
Teladorsagia species in cattle in developed countries such as New
Zealand. Therefore the use of this product should be based on local
(regional, farm) epidemiological information about susceptibility of
nematodes and recommendations on how to limit further selection for
resistance to anthelmintics.
In cases of lungworm infection in cattle, coughing may persist for a
considerable time following successful treatment with Levacide Low
Volume. This is due to tissue damage caused by the parasites.

i. Special precautions for use in animals
For oral administration only
Care should be taken to estimate accurately the liveweight of
animals to be treated. After treatment animals should be moved
to clean pasture in order to prevent re-infection.
Veterinary advice should be sought:
a) On appropriate dosing programmes and stock
management to achieve adequate parasite control, and to
reduce the likelihood of anthelmintic resistance developing.

Revised: 09 June 2010
AN: 00154/2010
b) If the product does not achieve the desired clinical effect
since other diseases, nutritional disturbances or anthelmintic
resistance might be involved.
ii. Special precautions to be taken by the person administering
the veterinary medicinal product to animals
Do not eat, drink or smoke when using this product. Wash
splashes from eyes and skin immediately. If irritation persists
seek medical advice. Remove any contaminated clothing
immediately. Wash hands and exposed skin after handling this
product and before meals.
Levamisole can cause idiosyncratic reactions and serious blood
disorders in a very small number of people. If symptoms such
as dizziness, nausea, vomiting or abdominal discomfort are
experienced when using this product, or sore mouth, throat or
fever occur shortly afterwards, then medical advice should be
sought immediately.