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Lambivac

Active ingredients: Clostridium perfringens, Clostridium tetani

Form

Injection

Species

Pigs Sheep

Manufacturer

Intervet International B.V.

VMD MA No.

06376/4111

What it's used for

Sheep For the active immunisation of sheep to: - reduce clinical signs and mortality due to the toxin of Clostridium tetani (Tetanus); - reduce mortality d...

Full indications, dosage and side effects ↓

View official SPC (PDF)

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Clinical information

Lambivac — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

Sheep
For the active immunisation of sheep to:
- reduce clinical signs and mortality due to the toxin of Clostridium tetani
(Tetanus);
- reduce mortality due to the epsilon toxin of Clostridium perfringens (Pulpy
kidney);
- induce a serological response against the beta toxin of Clostridium perfringens
(Struck, Lamb dysentery).
The vaccine may be used in pregnant ewes to provide passive immunisation of
lambs, provided that the lambs receive sufficient immune colostrum during the
first 12 hours of life, to:
- reduce clinical signs and mortality due to the toxin of Costridium tetani
(Tetanus);

Revised: December 2024
AN: 01537/2024
- reduce mortality due to the epsilon toxin of Clostridium perfringens (Pulpy
kidney)
- induce a serological response against the beta toxin of Clostridium perfringens
(Lamb dysentery).
Significant levels of immunity cannot be expected until two weeks after the
second dose of vaccine in the primary vaccination course.
From experience from field use, the duration of active immunity in lambs and
sheep is expected to last one year. The duration of passive protection in lambs
is approximately 12 weeks
colostrum during the first 12 hours of life.
Pigs
For active immunisation of sows against tetanus caused by Clostridium tetani.
Significant levels of immunity cannot be expected until two weeks after the
second dose of vaccine in the primary vaccination course. From experience
from field use, the duration of active immunity in pigs is expected to last one
year.
The vaccine may be used in pregnant sows to provide passive immunisation of
piglets, provided that the piglets receive sufficient immune colostrum during the
first 12 hours of life, to:
- reduce clinical signs and mortality due to the toxin of Clostridium tetani
(Tetanus);
- induce a serological response against to the toxin of
type C (Enterotoxemia).
The duration of the passive protection in piglets is 14 days.

The vaccine should be administered by subcutaneous injection in the lateral
side of the upper neck observing aseptic precautions.
Sheep and lambs: 2 ml/dose
Pigs: 5 ml/dose
Sheep
All sheep from 3 weeks of age onwards and not previously vaccinated with
Lambivac must receive two injections separated by an interval of 4-6 weeks to
be completed before onset of the period of risk. Thereafter they should receive
booster injections 2-3 weeks prior to identified risk periods with intervals of not
more than 12 months. In adult breeding ewes these yearly booster injections
should be given during the pre-lambing period, 4-6 weeks pre-lambing, to allow
passive protection of lambs via colostrum.

Revised: December 2024
AN: 01537/2024
Pigs
Two injections with an interval of at least 3 weeks between injections, the
second dose to be administered at least 3 weeks before farrowing. The
preferred schedule is vaccination at 6 and 3 weeks prior to the expected date of
farrowing. Only a single booster dose is required in subsequent pregnancies at
approximately 3-4 weeks pre-farrowing.
The vaccine bottle must be shaken well before use.
Syringes and needles must be from gamma irradiated packs or freshly sterilised
by boiling for at least 20 minutes. No alcohol or other disinfectants should be
used for sterilisation.
The use of an automatic vaccinator is recommended. Since the bottle is non-
collapsible, a vaccinator with a vented draw-off spike or similar device must be
used. The instructions supplied with such equipment should be noted and care
should be taken to ensure the delivery of the full dose, particularly with the final
few doses from the bottle.

None.

Occasional hypersensitivity may occur.
Vaccination may result in small (<10 cm) transient injection site reactions
possibly lasting for up to 3-4 months after vaccination.
Local tissue irritating effects of alhydrogel-adjuvanted vaccines reveal
granulomatous inflammatory reactions consisting mainly of activated
macrophages containing foamy cytoplasm, epithelioid cells, small lymphocytes
and multinuclear giant cells.

The nutritional and metabolic status of pregnant ewes is extremely important at
the time of vaccination. If in doubt, advice should be sought from a veterinary
surgeon.
No information is available on the efficacy of the vaccine in young animals with
maternally derived antibodies.

the person administering the medicinal product to animals
i. Special precautions for use in animals
In any group of animals, a small number of individuals may fail to respond
to vaccination as a result of immunological incompetence. Satisfactory
immune responses will only be attained in healthy animals, thus it is

Revised: December 2024
AN: 01537/2024
important to avoid vaccination of animals which have an intercurrent
infection or metabolic disorder.
When handling animals, stress should be avoided, particularly during the
later stages of pregnancy when there is a risk of inducing abortion and
metabolic disorders.
ii. Special precautions to be taken by the person administering the veterinary
medicinal product to animals
In case of accidental self-injection, seek medical advice immediately and
show the package leaflet or the label to the physician.

No information is available on the safety and efficacy of this vaccine with any
other veterinary medicinal product. A decision to use this vaccine before or after
any other veterinary medicinal product is therefore on a case by case basis.

Store in a refrigerator (2C - 8C).
Do not freeze.

Zero days.
5. IMMUNOLOGICAL PROPERTIES
ATCvet code: Sheep: QI04AB01 Pigs: QI09AB12
To stimulate active immunity and to provide passive immunity to the progeny
against clostridial diseases.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.