POM-V Prescription Required

Entericolix, Emulsion for Injection for Pig

Active ingredients: Clostridium perfringens, Escherichia coli

Form

Injection

Species

Pigs

Manufacturer

CZ Vaccines S.A.U.

VMD MA No.

30824/4003

What it's used for

expressing F4ac, F5, F6, F18ac and F41 adhesins, against oedema disease caused by E. coli strain expressing F18ab adhesin and against necrotic enteritis ca...

Full indications, dosage and side effects ↓

View official SPC (PDF)

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Clinical information

Entericolix, Emulsion for Injection for Pig — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

expressing F4ac, F5, F6, F18ac and F41 adhesins, against oedema disease caused
by E. coli strain expressing F18ab adhesin and against necrotic enteritis caused by
C. perfringens
Neonatal piglets
- The vaccine reduces mortality and clinical signs (severe diarrhoea) due to
colibacillosis.
- The vaccine reduces mortality and clinical signs due to necrotic enteritis caused
by C. perfringens
Weaned piglets
- The vaccine reduces mortality and clinical signs due to oedema disease.
- The vaccine reduces clinical signs (severe diarrhoea) of colibacillosis.
- The vaccine reduces clinical signs of chronic enteritis due to C. perfringens
C.
Duration of immunity:
- 21 days for infections caused by F4ac, F18ac, (colibacillosis) and C. perfringens
type C (necrotic enteritis).
- 21 days for antibodies against F5, F6 and F41, however the protective efficacy
of the antibody levels was not established.
- 28 days for infections caused by F18ab (oedema disease).

Shake vigorously before use and at intervals during use.
Avoid introduction of contamination during use.
Doses
Sows and gilts: 2 ml.
Before use, allow the vaccine to reach room temperature and shake the bottle
vigorously. Inoculate the corresponding dose by deep intramuscular injection in the
neck muscles. It is very important to use needles of appropriate length according to
the weight of the animal.
It is recommended that the second dose should be given preferably on the alternate
side.
Vaccination schedule
Pregnant sows: The initial course consists of two doses. Administer one dose
7 weeks before farrowing followed by a second dose 4 weeks before farrowing.
Revaccinate with a single dose 4 weeks before farrowing in subsequent gestation
periods.

Do not use in cases of hypersensitivity to the active substances, to the adjuvants or
to any of the excipients.

Pigs:
Very common
(>1 animal / 10 animals treated):
Hyperthermia1
Common
(1 to 10 animals / 100 animals treated):
Apathy
Rare
(1 to 10 animals / 10,000 animals treated):
Injection site swelling, injection site
reddening
Very rare
(<1 animal / 10,000 animals treated,
including isolated reports):
Anaphylactic-type reaction
1
Transient, maximum 2 ºC, between 4 – 24 hours after vaccination. Temperatures
return to normal values within 24 – 48 hours.
Between 1- and 2-days post-vaccination, uncommonly may last for up to 7 days
after vaccination.
With a maximum diameter of 3 cm and a maximum of 10 days of duration.
May be fatal.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.
AN: 01156/2024 & 01571/2024Page 4 of 6

Vaccinate healthy animals only.

Special precautions for safe use in the target species:
Not applicable.
AN: 01156/2024 & 01571/2024Page 3 of 6
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
To the user:
This veterinary medicinal product contains mineral oil. Accidental injection/self-
injection may result in severe pain and swelling, particularly if injected into a joint or
finger, and in rare cases could result in the loss of the affected finger if prompt
medical attention is not given. If you are accidentally injected with this veterinary
medicinal product, seek prompt medical advice even if only a very small amount is
injected and take the package leaflet with you. If pain persists for more than 12 hours
after medical examination, seek medical advice again.
To the physician
This veterinary medicinal product contains mineral oil. Even if small amounts have
been injected, accidental injection with this veterinary medicinal product can cause
intense swelling, which may, for example, result in ischaemic necrosis and even the
loss of a digit. Expert, PROMPT, surgical attention is required and may necessitate
early incision and irrigation of the injected area, especially where there is involvement
of finger pulp or tendon.>
Special precautions for the protection of the environment:
Not applicable.

No information is available on the safety and efficacy of this vaccine when used with
any other veterinary medicinal product. A decision to use this vaccine before or after
any other veterinary medicinal product therefore needs to be made on a case by
case basis.

Store and transport refrigerated (2 °C – 8 °C).>
Do not freeze.
Protect from light.

Zero days.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.