POM-V Prescription Required Companion Animal

Ketofen 5 mg Tablets

Active ingredient: Ketoprofen

Form

Tablet

Species

Cats Dogs

Manufacturer

Ceva Sante Animale

VMD MA No.

14966/5039

What it's used for

For the treatment of bovine respiratory disease (BRD) caused by haemolytica and of associated clinical signs of inflammation or pyrexia.

Full indications, dosage and side effects ↓

View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for Ketoprofen

1

Ask your vet for a written prescription

They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

Fill it at a registered online retailer

The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Your prescription rights → VMD register of retailers →

Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Ketofen 5 mg Tablets — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

For the treatment of bovine respiratory disease (BRD) caused by
haemolytica and
of associated clinical signs of inflammation or pyrexia.

Intramuscular use.
1 mg ceftiofur/kg/day and 3 mg ketoprofen/kg/day by intramuscular injection,
1 ml/50 kg at each injection. The product should only be used when the disease
is associated with clinical signs of inflammation or pyrexia. The product may be
administered for 1 to 5 consecutive days depending upon the clinical response
on a case by case basis. As the duration for the antibiotic treatment should not
be less than 3 to 5 days, when inflammation and pyrexia have subsided, the
veterinarian should switch to a ceftiofur only-containing product in order to cover
3 to 5 days of continuous antibiotic treatment. Only few animals are expected to
require a fourth or fifth injection with the combined product.
Shake the bottle vigorously for 20 seconds before use to ensure an
homogeneous suspension.
Resuspension could be longer after storage at low temperatures.
To ensure correct dosage body weight should be determined as accurately as
possible to avoid underdosing.
The user should use the most appropriate vial size according to the number of
animals to treat.
The 50 ml and 100 ml vials should not be pierced more than 10 times and the
250 ml not more than 18 times. The use of an aspirating needle may be
recommended to avoid excessive broaching of the stopper.
Subsequent intramuscular injections must be given at different sites.
Not more than 16 ml should be administered per injection site.

Do not use in cases of known resistance to other cephalosporins or beta-
lactam antibiotics.
Do not use in cases of hypersensitivity to ceftiofur and other -lactam
antibiotics.
Do not use in cases of hypersensitivity to ketoprofen.
Do not use in poultry (including eggs) due to risk of spread of antimicrobial
resistance to humans.
Do not administer other non-steroidal anti-inflammatory drugs (NSAIDs) and
corticosteroids concurrently or within 24 hours of each other.

Revised: October 2019
AN: 00636/2019
Do not use in animals suffering from cardiac, hepatic or renal disease, where
there is the possibility of gastro-intestinal ulceration or bleeding, where there is
evidence of a blood dyscrasia.

In field studies, the product has been tested in cattle aged from 1 month old to
12 years without evidencing safety concern.
Mild inflammatory reactions at the injection site, such as tissue oedema, without
pain in most cases, were commonly observed in studies.
Hypersensitivity reactions (e.g. skin reactions, anaphylaxia) unrelated to dose
and discolouration of the subcutaneous tissue and/or muscle can very rarely be
observed.
Gastric or renal intolerance can be observed very rarely in certain individuals, in
common with all NSAIDs due to their action of inhibition of prostaglandin
synthesis.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse
reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated
reports).

Avoid use in any dehydrated, hypovolaemic or hypotensive animals as there is
a potential risk of increased renal toxicity.

i) Special precautions for use in animals
In case of the occurrence of allergic reaction the treatment should be
withdrawn.
The product selects for resistant strains such as bacteria carrying extended
spectrum betalactamases (ESBL) and may constitute a risk to human health if
these strains disseminate to humans e.g. via food. For this reason, the product
should be reserved for the treatment of clinical conditions which have
responded poorly, or are expected to respond poorly (refers to very acute cases
when treatment must be initiated without bacteriological diagnosis) to first line
treatment.
When inflammation or pyrexia have subsided, the veterinarian should switch
to a ceftiofur only-containing product in order to cover 3 to 5 days of
continuous antibiotic treatment. Treating for an appropriate length of time is
important to limit development of resistance.
Official, national and regional antimicrobial policies should be taken into account
when the product is used. Increased use, including use of the product deviating
from the instructions given in the SPC, may increase the prevalence of such
resistance. Whenever possible, the product should only be used based on
susceptibility testing.
The product is intended for treatment of individual animals. Do not use for
disease prevention or as a part of herd health programmes. Treatment of
groups of animals should be strictly restricted to ongoing disease outbreaks
according to the approved conditions of use.
The concomitant use of diuretics or coagulant should be based on a benefit/risk
assessment of the responsible veterinarian.
Avoid intra-arterial and intravenous injection.
Use preferably a 14 gauge needle.
ii) Special precautions to be taken by the person administering the veterinary
medicinal product to animals
Penicillins and cephalosporins may cause hypersensitivity (allergy) following
injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may
lead to cross reactions to cephalosporins and vice versa. Ketoprofen may also
cause hypersensitivity.
be serious.

Revised: October 2019
AN: 00636/2019
Do not handle this product if you know you are sensitised to active substances
or to any of excipients, or if you have been advised not to work with such
preparations.
Wash hands after use.
Avoid contact with eyes and skin. In case of contact, wash immediately with
water.
If you develop symptoms following exposure such as a skin rash, you should
seek medical advice and show the doctor this warning.
Swelling of the face, lips or eyes or difficulty with breathing are more serious
symptoms and require urgent medical attention.
In case of accidental self injection seek medical advice immediately and show
the package leaflet or the label to the physician.

Some NSAIDs may be highly bound to plasma proteins and compete with other
highly bound drugs which can lead to toxic effects.
Do not use in combination with other NSAIDs or with corticosteroids, diuretics,
nephrotoxic drugs or anticoagulants.
The bactericidal properties of beta-lactams are neutralised by simultaneous use
of bacteriostatic antibiotics (macrolides, sulphonamides and tetracyclines).

Do not freeze.
Keep the glass vial in the outer carton in order to protect from light.

Meat and offal: 8 days
Milk: zero hours

Revised: October 2019
AN: 00636/2019
5.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.