POM-V Prescription Required

Ketiva 150 mg/ml Solution for Injection for Cattle, Pigs and Horses

Active ingredient: Ketoprofen

Form

Injection

Species

Cattle Horses Pigs

Manufacturer

VetViva Richter GmbH

VMD MA No.

57446/3008

What it's used for

- Reduction of fever associated with bovine respiratory disease. - Reduction of inflammation, fever and pain in acute clinical mastitis in combination with...

Full indications, dosage and side effects ↓

View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for Ketoprofen

1

Ask your vet for a written prescription

They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

Fill it at a registered online retailer

The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Your prescription rights → VMD register of retailers →

Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Ketiva 150 mg/ml Solution for Injection for Cattle, Pigs and Horses — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

- Reduction of fever associated with bovine respiratory disease.
- Reduction of inflammation, fever and pain in acute clinical mastitis in combination
with antimicrobial therapy where appropriate.
- Reduction of post-operative pain associated with dehorning in calves.
Pigs:
- Reduction of pyrexia in cases of respiratory disease and Postpartum Dysgalactia
Syndrome-PDS-(Metritis Mastitis Agalactia syndrome) in sows, in combination with
antimicrobial therapy, where appropriate.
AN: 04316/2024 & 04317/2024
Horses:
- Reduction of inflammation and pain associated with osteoarticular and
musculoskeletal disorders (lameness, laminitis, osteoarthritis, synovitis, tendinitis,
etc.).
- Reduction of postoperative pain and inflammation.
- Reduction of visceral pain associated with colic.

Pigs: intramuscular use (i.m.)
Horses: intravenous use (i.v.)
To ensure a correct dosage, body weight should be determined as accurately as
possible. The use of suitably calibrated measuring equipment is recommended.
Cattle:
3 mg of ketoprofen/kg body weight, i.e. 1 ml of the veterinary medicinal product/50
kg body weight/ day, administered via the i.v. or i.m. route, preferably in the neck
region.
AN: 04316/2024 & 04317/2024
For the reduction of post-operative pain associated with dehorning in calves, it is
recommended to administer the veterinary medicinal product at the same time as the
local anaesthetic 10 - 30 minutes before dehorning.
The duration of treatment is 1-3 days, and should be established according to the
severity and duration of symptoms.
Pigs:
3 mg of ketoprofen/kg body weight, i.e. 1 ml of the veterinary medicinal product/50
kg body weight/day, administered via the i.m. route on a single occasion.
Depending on the response observed and based on the benefit-risk analysis by the
responsible veterinarian, treatment may be repeated at intervals of 24 hours for a
maximum of three treatments. Each injection should be given at a different site.
Horses:
2.2 mg of ketoprofen/kg body weight, i.e. 0.75 ml of the veterinary medicinal
product/50 kg body weight/day, administered via the i.v. route.
The duration of treatment is 1-5 days, and should be established according to the
severity and duration of symptoms. In the case of colic, one injection is normally
sufficient. A second administration of ketoprofen requires a clinical re-examination.
The rubber stopper can be punctured a maximum of 25 times. To prevent excessive
puncturing of the rubber stopper, when treating a large number of animals with small
volumes, use of a dispensing pin is recommended.

Do not use in animals where there is the possibility of gastro-intestinal ulceration or
bleeding, in order not to aggravate their situation.
Do not use in animals suffering from cardiac, hepatic, or renal disease.
Do not use in cases of hypersensitivity to the active substance or to any of the
excipients.
Do not use in animals with evidence of blood dyscrasia or coagulopathy.
Do not administer other non-steroidal anti-inflammatory drugs (NSAIDs) concurrently
or within 24 hours of each other.

Cattle, pigs:
Very rare (<1 animal / 10,000
animals treated, including
isolated reports):
Injection site necrosis
;
Digestive tract disorder
;
Renal disorder.
When injected intramuscularly. Lesions are subclinical, mild and gradually resolve
in the days after completion of treatment. Administration in the neck region
minimizes the extension and severity of these lesions.
Erosive and ulcerative lesions after repeated administration, gastric intolerance.
Horses:
Very rare (<1 animal / 10,000 animals
treated, including isolated reports):
Injection site necrosis
, Injection site
reaction
;
Digestive tract disorder
;
Renal disorder.
When injected intramuscularly. Lesions are subclinical, mild and gradually resolve
in the days after completion of treatment. Administration in the neck region
minimizes the extension and severity of these lesions.
Local reaction resolving after 5 days, after one administration of the veterinary
medicinal product at the recommended volume by extravascular route.
Erosive and ulcerative lesions after repeated administration, gastric intolerance.
AN: 04316/2024 & 04317/2024
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian,
to either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.

Treatment of calves with ketoprofen 10 - 30 minutes before dehorning reduces
post-operative pain. Ketoprofen alone will not provide adequate pain relief during the
dehorning procedure. To obtain adequate pain relief during dehorning, co-medication
with an appropriate local anaesthetic is needed.

Special precautions for safe use in the target species:
Avoid intra-arterial injection. Do not exceed recommended dose and period of
treatment.
The use of ketoprofen is not recommended in foals less than one month of age.
When administering to animals of less than 6 weeks of age, ponies or in aged
animals, it is necessary to adjust the dose accurately as well as to perform a close
clinical follow-up.
Avoid use in any dehydrated, hypovolaemic or hypotensive animals as there is a
potential risk of increased renal toxicity.
Animals should have adequate access to drinking water over the course of
treatment.
Since gastric ulceration is a common finding in PMWS (Post-weaning Multisystemic
Wasting Syndrome), the use of ketoprofen in pigs affected by this pathology is not
recommended, in order not to aggravate their situation.
In horses, avoid extravascular administration.
AN: 04316/2024 & 04317/2024
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
Ketoprofen and benzyl alcohol can cause hypersensitivity reactions. People with
known hypersensitivity to ketoprofen or benzyl alcohol should avoid contact with the
veterinary medicinal product.
This veterinary medicinal product may be irritant to the skin, eyes and mucous
membranes. Avoid contact with the skin, eyes and mucous membranes. In case of
accidental skin, eye or mucous membrane contact, wash the affected area
thoroughly with clean running water immediately. Seek medical advice if irritation
persists.
This veterinary medicinal product may cause somnolence, dizziness, nausea and
vomiting. Avoid accidental self-injection. In case of accidental self-injection, seek
medical advice immediately and show the package leaflet or the label to the
physician.
NSAIDs, such as ketoprofen, may affect fertility and be harmful for the unborn child.
Pregnant and breastfeeding women should administer the veterinary medicinal
product with caution.
Wash hands after use.
Special precautions for the protection of the environment:
Not applicable.

- Concurrent administration of diuretics or potentially nephrotoxic drugs should be
avoided since there is an increase of renal disturbances, including renal failure. This
is secondary to the diminished blood flow caused by the inhibition of prostaglandins
synthesis.
- Do not administer other NSAIDs, corticosteroids, anticoagulants or diuretics
concurrently or within 24 hours of administration of the veterinary medicinal product
since the risk of gastrointestinal ulceration and other adverse reactions may be
exacerbated.
- The treatment free period should however take into account the pharmacological
properties of the veterinary medicinal products used previously.
- Ketoprofen is highly bound to plasma proteins and may compete with other highly
bound drugs which can lead to toxic effects.

Do not freeze.

Meat and offal:
Cattle: 2 days
Pigs: 3 days
Horses: 1 day
Milk:
Cattle:zero hours
Not authorised for use in mares producing milk for human consumption.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.