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AVM-GSL Over the Counter Companion Animal

Johnson's 4fleas 80 mg Spot-on Solution for Cats

Active ingredient: Imidacloprid

Form

Spot-on

Species

Cats

Manufacturer

Elanco Europe Ltd

VMD MA No.

00879/5079

What it's used for

For the prevention and treatment of flea (Ctenocephalides felis) infestations on cats of 4 kg bodyweight and greater. One treatment prevents further flea i...

Full indications, dosage and side effects ↓
View official SPC (PDF)

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Paying less for Imidacloprid

  1. 1

    Ask your vet for a written prescription

    They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.

  2. 2

    Fill it at a registered online retailer

    The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Clinical information

Johnson's 4fleas 80 mg Spot-on Solution for Cats — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

For the prevention and treatment of flea (Ctenocephalides felis) infestations on
cats of 4 kg bodyweight and greater.
One treatment prevents further flea infestation for three to four weeks.
In very rare occasions skin reactions such as hair loss, redness, itching and skin
lesions may occur. Agitation, excessive salivation and nervous signs such as
incoordination, tremors and depression have also been reported.
Oral ingestion may result in other gastrointestinal signs (vomiting and
diarrhoea), which have been observed very rarely based on post-marketing
data.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals displaying adverse reactions during
the course of one treatment)
- common (more than 1 but less than 10 animals in 100 animals)
- uncommon (more than 1 but less than 10 animals in 1,000 animals)
- rare (more than 1 but less than 10 animals in 10,000 animals)
- very rare (less than 1 animal in 10,000 animals, including isolated reports).
4.7 Use during pregnancy, lactation or lay
No primary embryotoxic, teratogenic or reproductive toxic effects have been
observed during the studies with imidacloprid on rats and rabbits. Studies on
pregnant and lactating queens together with their offspring are limited. Evidence
so far suggests that no adverse effects are to be expected in these animals.
4.8 Interaction with other medicinal products and other forms of interaction
No incompatibility has been observed between this product at twice the
recommended dose and the following commonly used veterinary products:
lufenuron, pyrantel and praziquantel. The compatibility of the product was also

Revised: December 2025
MA split from NI Expiry following AN: 02123/2025
demonstrated with a wide range of routine treatments under field conditions
including vaccination.
4.9 Amounts to be administered and administration route
Dosage and Treatment Schedule
Product Cat (kg bw)Number of
Pipettes
Imidaclopri
d
(mg/kg bw)
Johnson’s 4fleas 80
mg Spot-on solution
for cats
≥ 4 kg 1 x 0.8 ml minimum of
Cats weighing less than 4kg bodyweight: use Johnson’s 4fleas 40 mg Spot-on
solution for kittens and small cats
Method of Administration
Remove one pipette from the package. Hold pipette in an upright position, twist
and pull off cap. Use reversed cap to twist and remove seal from pipette.
Part the hair on the cat's neck at the base of the skull until the skin is visible.
Place the tip of the pipette on the skin and squeeze firmly several times to
empty the contents directly onto the skin.
The product is bitter tasting and salivation may occasionally occur if the cat licks
the application site immediately after treatment. This is not a sign of intoxication
and disappears within some minutes without treatment. Application at the base
of the skull will minimize the opportunity for the cat to lick the product.
Apply only to undamaged skin.
Do not treat unweaned kittens of less than 8 weeks of age.
Do not use in cases of hypersensitivity to the active substance or to any of the
excipients.
The product is bitter tasting and salivation may occasionally occur if the cat licks
the application site immediately after treatment. This is not a sign of intoxication
and disappears within some minutes without treatment (see also section 4.9
Amounts to be administered and administration route
In very rare occasions skin reactions such as hair loss, redness, itching and skin
lesions may occur. Agitation, excessive salivation and nervous signs such as
incoordination, tremors and depression have also been reported.
Oral ingestion may result in other gastrointestinal signs (vomiting and
diarrhoea), which have been observed very rarely based on post-marketing
data.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals displaying adverse reactions during
the course of one treatment)
- common (more than 1 but less than 10 animals in 100 animals)
- uncommon (more than 1 but less than 10 animals in 1,000 animals)
- rare (more than 1 but less than 10 animals in 10,000 animals)
- very rare (less than 1 animal in 10,000 animals, including isolated reports).
Re-infestation from emergence of new fleas in the environment may continue to
occur for six weeks or longer after treatment is initiated. More than one
treatment may therefore be required, depending on the level of fleas in the

Revised: December 2025
MA split from NI Expiry following AN: 02123/2025
environment. To aid reduction in environmental challenge, the additional use of
a suitable environmental treatment against adult fleas and their developing
stages is recommended. In order to reduce further the environmental challenge,
it is recommended that all dogs, cats and rabbits in the household are treated
with a suitable product.
If there are several pets in the household, it is advisable to treat all pets at the
same time. Fleas can be detected by parting pet's coat and examining skin for
signs of flea activity or by combing coat with a fine-toothed flea comb. Frequent
scratching or excessive grooming can also be signs of flea infestation. Fleas
from pets often infest pet's basket, bedding and regular resting areas, such as
carpets and soft furnishings which should be vacuumed regularly and treated
periodically with an insecticide suitable for household use, preferably containing
an I.G.R. (Insect Growth Regulator) to control flea egg development and help
break the flea life cycle. Wash and change pet bedding regularly.
The product remains effective if the animal becomes wet, for example after
exposure to heavy rain. However, re-treatment may become necessary,
depending on the presence of fleas in the environment. In these cases do not
treat more frequently than once weekly.
If symptoms of disease persist or appear, consult a veterinary surgeon.

i) Special precautions for use in animals
This product is for topical use and should not be administered orally.
Care should be taken to avoid the contents of the pipette coming into
contact with the eyes or mouth of the recipient animal.
Do not allow recently treated animals to groom each other.
Apply only to undamaged skin.
Any collar should be removed prior to application of the product. Prior to
re-fitting the collar, the treated area should be visually assessed to ensure
it is dry.
ii) Special precautions to be taken by the person administering the veterinary
medicinal product to animals
People with known hypersensitivity to imidacloprid or benzyl alcohol
should avoid contact with the veterinary medicinal product.
This product contains benzyl alcohol and may cause skin sensitisation or
transient skin reactions in rare cases (for example, irritation, tingling).
Avoid contact of the product with the eyes or mouth.
Do not eat, drink or smoke during application.
Wash off any skin contamination with soap and water.
After application, do not stroke or groom pets until application site is dry.
It is therefore recommended that animals are not treated during the day,
but should be treated during the early evening, and that recently treated
animals are not allowed to sleep with owners, especially children.

Revised: December 2025
MA split from NI Expiry following AN: 02123/2025
If the product gets into eyes accidentally, the eyes should be thoroughly
rinsed with clean water. If skin or eye irritation persists, or the product is
accidentally swallowed, obtain medical attention, showing the package
leaflet or carton to the physician.
Wash hands thoroughly after use.
In order to prevent children from getting access to pipettes, keep the
pipette in the original packaging until ready for use and dispose of used
pipettes immediately.
iii) Other precautions
Keep treated pets away from materials such as leather, soft furnishings,
plastics etc. until site of application is completely dry as contact may
damage these surfaces.
No incompatibility has been observed between this product at twice the
recommended dose and the following commonly used veterinary products:
lufenuron, pyrantel and praziquantel. The compatibility of the product was also

Revised: December 2025
MA split from NI Expiry following AN: 02123/2025
demonstrated with a wide range of routine treatments under field conditions
including vaccination.
This veterinary medicinal product does not require any special storage
conditions.
Keep the blister in the outer carton
For the full list of excipients, see section

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.

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