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AVM-GSL Over the Counter Companion Animal

Johnson’s 4fleas 40 mg Spot-on Solution for Dogs less than 4 kg

Active ingredient: Imidacloprid

Form

Spot-on

Species

Dogs

Manufacturer

Elanco Europe Ltd

VMD MA No.

00879/5080

What it's used for

For the prevention and treatment of flea infestations and for the treatment of biting lice (Trichodectes canis) on dogs of less than 4 kg body weight. Flea...

Full indications, dosage and side effects ↓
View official SPC (PDF)

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Paying less for Imidacloprid

  1. 1

    Ask your vet for a written prescription

    They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.

  2. 2

    Fill it at a registered online retailer

    The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Clinical information

Johnson’s 4fleas 40 mg Spot-on Solution for Dogs less than 4 kg — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

For the prevention and treatment of flea infestations and for the treatment of
biting lice (Trichodectes canis) on dogs of less than 4 kg body weight.
Fleas are killed within one day following treatment. One treatment prevents
further flea infestation for four weeks.
In very rare occasions skin reactions such as hair loss, redness, itching and skin
lesions may occur. Agitation, disorientation and, in exceptional cases, excessive
salivation and nervous signs such as incoordination, tremors and depression
have been reported.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals displaying adverse reactions during
the course of one treatment)
- common (more than 1 but less than 10 animals in 100 animals)
- uncommon (more than 1 but less than 10 animals in 1,000 animals)
- rare (more than 1 but less than 10 animals in 10,000 animals)
- very rare (less than 1 animal in 10,000 animals, including isolated reports).
4.7 Use during pregnancy, lactation or lay
No primary embryotoxic, teratogenic or reproductive toxic effects have been
observed during the studies with imidacloprid on rats and rabbits. Studies on
pregnant and lactating bitches together with their offspring are limited. Evidence
so far suggests that no adverse effects are to be expected in these animals.

Revised: December 2025
MA split from NI Expiry following AN: 02130/2025
Consult your veterinary surgeon before using in pregnant or nursing animals
4.8 Interaction with other medicinal products and other forms of interaction
No incompatibility has been observed between this product at twice the
recommended dose and the following commonly used veterinary products:
fenthion, lufenuron, milbemycin, febantel, pyrantel and praziquantel. The
compatibility of the product was also demonstrated with a wide range of routine
treatments under field conditions including vaccination.
Do not use simultaneously with other flea products which are applied directly
onto the animal
4.9 Amounts to be administered and administration route
Dosage and Treatment Schedule
ProductDog (kg bw)Number of
Pipettes
Imidacloprid
(mg/kg bw)
Johnson’s 4fleas 40 mg
Spot-on solution for dogs
less than 4 kg
< 4 kg1 x 0.4 mlminimum of 10Dogs weighing 4kg bodyweight: use the appropriate Johnson’s 4fleas Spot-on
solution for dogs [UK] / Advantage Flea Control Spot-on solution for dogs [IE]
product
Method of Administration
Remove one pipette from the package. Hold pipette in an upright position, twist
and pull off cap. Use reversed cap to twist and remove seal from pipette.
With the dog in the standing position, part the coat between the shoulder blades
until the skin is visible. Place the tip of the pipette on the skin and squeeze
firmly several times to empty the contents directly onto the skin.

Revised: December 2025
MA split from NI Expiry following AN: 02130/2025
Do not apply an excessive amount of solution at any one spot that could cause
some of the solution to run off the side of the dog.
The product is bitter tasting and salivation may occasionally occur if the dog
licks the application site immediately after treatment. This is not a sign of
intoxication and disappears within some minutes without treatment. Correct
application will minimize the opportunity for the dog to lick the product.
Apply only to undamaged skin.
Do not treat unweaned puppies of less than 8 weeks of age.
Do not use in animals that are known to be hypersensitive to the active
substance or any of the excipients.
The product is bitter tasting and salivation may occasionally occur if the animal
licks the application site immediately after treatment. This is not a sign of
intoxication and disappears within some minutes without treatment (see also
section 4.9 Amounts to be administered and administration route).
In very rare occasions skin reactions such as hair loss, redness, itching and skin
lesions may occur. Agitation, disorientation and, in exceptional cases, excessive
salivation and nervous signs such as incoordination, tremors and depression
have been reported.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals displaying adverse reactions during
the course of one treatment)
- common (more than 1 but less than 10 animals in 100 animals)
- uncommon (more than 1 but less than 10 animals in 1,000 animals)
- rare (more than 1 but less than 10 animals in 10,000 animals)
- very rare (less than 1 animal in 10,000 animals, including isolated reports).
Re-infestation from emergence of new fleas in the environment may continue to
occur for six weeks or longer after treatment is initiated. More than one

Revised: December 2025
MA split from NI Expiry following AN: 02130/2025
treatment may therefore be required, depending on the level of fleas in the
environment. To aid reduction in environmental challenge, the additional use of
a suitable environmental treatment against adult fleas and their developing
stages is recommended. In order to reduce further the environmental challenge,
it is recommended that all dogs, cats and rabbits in the household are treated
with a suitable product.
If there are several pets in the household, it is advisable to treat all pets at the
same time. Fleas can be detected by parting pet's coat and examining skin for
signs of flea activity or by combing coat with a fine-toothed flea comb. Frequent
scratching or excessive grooming can also be signs of flea infestation. Fleas
from pets often infest pet's basket, bedding and regular resting areas, such as
carpets and soft furnishings which should be vacuumed regularly and treated
periodically with an insecticide suitable for household use, preferably containing
an I.G.R. (Insect Growth Regulator) to control flea egg development and help
break the flea life cycle. Wash and change pet bedding regularly.
The product remains effective if the animal becomes wet, for example after
swimming or exposure to heavy rain. However, in cases of frequent swimming
or bathing re-treatment may become necessary, depending on the presence of
fleas in the environment. In these cases do not treat more frequently than once
weekly.
In case of biting louse infestation, the animal should be re-examined 30 days
after treatment as some animals may require a second treatment.
If signs of disease persist or appear, consult a veterinary surgeon

i. Special precautions for use in animals
This product is for topical use and should not be administered orally.
Care should be taken to avoid the contents of the pipette coming into
contact with the eyes or mouth of the recipient animal.
Do not allow recently treated animals to groom each other.
Apply only to undamaged skin.
ii. Special precautions to be taken by the person administering the veterinary
medicinal product to animals
People with known skin sensitivity to imidacloprid or benzyl alcohol may be
particularly sensitive to this product and should avoid contact with the
veterinary medicinal product.
This product contains benzyl alcohol and may cause skin sensitisation or
transient skin reactions in rare cases (for example, irritation, tingling).
Avoid contact of the product with the eyes or mouth. Do not eat, drink or
smoke during application.
Wash off any skin contamination with soap and water.

Revised: December 2025
MA split from NI Expiry following AN: 02130/2025
After application, do not stroke or groom pets until application site is dry.
It is therefore recommended that animals are not treated during the day,
but should be treated during the early evening, and that recently treated
animals are not allowed to sleep with owners, especially children.
If the product gets into eyes accidentally, the eyes should be thoroughly
rinsed with clean water. If skin or eye irritation persists, or the product is
accidentally swallowed, obtain medical attention, showing the package
leaflet or carton to the physician.
Wash hands thoroughly after use.
In order to prevent children from getting access to pipettes, keep the
pipette in the original packaging until ready for use and dispose of used
pipettes immediately.
iii. Other precautions
Imidacloprid is toxic to aquatic organisms. To avoid adverse effects on
aquatic organisms, treated dogs should not be allowed to enter water
courses for 48 hours after treatment.
Keep treated pets away from materials such as leather, soft furnishings,
plastics, etc until site of application is completely dry as contact may
damage these surfaces.
No incompatibility has been observed between this product at twice the
recommended dose and the following commonly used veterinary products:
fenthion, lufenuron, milbemycin, febantel, pyrantel and praziquantel. The
compatibility of the product was also demonstrated with a wide range of routine
treatments under field conditions including vaccination.
Do not use simultaneously with other flea products which are applied directly
onto the animal
This veterinary medicinal product does not require any special temperature
storage conditions.
Keep the blister in the outer carton.
Not applicable.
5.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.

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