POM-V Prescription Required Companion Animal

Incurin 1 mg Tablet

Active ingredient: Estriol

Form

Tablet

Species

Dogs

Manufacturer

MSD Animal Health UK Limited

VMD MA No.

01708/5038

View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for Estriol

1

Ask your vet for a written prescription

They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

Fill it at a registered online retailer

The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Your prescription rights → VMD register of retailers →

Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Incurin 1 mg Tablet — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

A relationship between the final effective dose and body weight has not been
established and therefore the dose must be determined for each dog on an individual
basis.
Recommended dosing schedule:
Start treatment with 1 tablet (1 mg estriol) every day.
If treatment is successful, lower the dose to half a tablet per day.
If treatment is not successful, increase the dose to 2 tablets per day to be
administered as a single dose.
Do not use more than 2 tablets per dog per day.
The minimum dose should not be less than half a tablet (0.5 mg estriol) per dog per
day.
Ensure the dose used to achieve the therapeutic effect is as low as possible.
Some dogs do not need daily treatment. Once an effective daily dose has been
established, treatment every other day may be tried.
If no response to treatment is achieved, the diagnosis should be reconsidered and
other causes for the incontinence such as neurological disorders, bladder neoplasia,
etc. investigated.
Animals should be re-examined every 6 months during treatment.

Do not use in intact bitches as the efficacy has only been established in
ovariohysterectomised bitches.
Do not use in animals with symptoms of polyuria-polydipsia.
Do not use in animals younger than 1 year.

Dog (bitch):
Very common
(> 1 animal / 10 animals treated):
Swollen vulva
1,2
, mammary gland
oedema
1,2
, attractiveness to males
1,2
.
Vomiting
1,2
.
Rare
(1 to 10 animals / 10 000 animals treated):
Vaginal haemorrhage.
Alopecia.
Observed at the highest recommended dose of 2 mg per dog.
These effects are reversible after lowering the dose.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or the national competent authority via the
national reporting system. See the package leaflet for respective contact details.

High doses of oestrogen may have a tumour-promoting effect in target organs with
oestrogen receptors (mammary glands).

Special precautions for safe use in the target species:
In case of oestrogenic effects, the dose should be lowered.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Not applicable.
Special precautions for the protection of the environment:
Not applicable.

None known.

Do not store above 30 °C.

Not applicable.
4.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.

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Your Rights

Prescription Fee Cap Can My Vet Refuse a Prescription? Buy Pet Medication Online

Same active ingredient

Other Products Containing Estriol

These products share the same active ingredient and may be suitable alternatives. Always consult your vet.

Incurin 1 mg Tablet

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