Hypertonic 72 mg/ml Solution for Infusion for Cattle, Cattle (Calves), Horses, Dogs and Cats

None.

Special precautions for safe use in the target species:
Do not use unless the solution is clear, free from visible particles, and the container is
undamaged.
Maintain aseptic precautions.
Administration of the solution must be accompanied by an opportunity for the animal
to drink ad libitum.
This veterinary medicinal product should ideally be warmed to approximately 37 °C
prior to the administration of large volumes, or if the administration rate is high, in
order to avoid hypothermia.
Any existing haemorrhage should be stopped or controlled before treatment.
Hypertonic solutions must be administered solely by the intravenous route.
Animals treated with this veterinary medicinal product should be closely observed for
possible deterioration of the clinical condition as a consequence of treatment.
Repeated infusion should only be performed after checking sodium concentration
and acid-base status.
Rapid infusion of hypertonic NaCl can lead to myelinolysis in the brain in animals with
chronic hyponatraemia.
Do not use the veterinary medicinal product as a vehicle for the administration of
other veterinary medicinal products.
Care should be taken to avoid the use of excessive doses (>8 ml/kg) and excessive
dose rates (>1 ml/kg/minute).
Excessive administration of chloride may, due to the electrolytes’ interaction with the
body’s bicarbonate buffer system exert an acidifying effect. Therefore, in clinical
AN: 02591/2024, 02593/2024, 03220/2024, 03566/2024, 04026/2024 and 04027/2024
instances accompanied by acidosis and hyperchloremia, special care has to be taken
if this veterinary medicinal product is to be infused.
Sodium chloride administration may aggravate a pre-existing hypokalaemia.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
None.
Special precautions for the protection of the environment:
Not applicable.