POM-V
Prescription Required
Hypermune-RE Equine Plasma
Active ingredients: Equine plasma, Rhodococcus equi
Form
Solution
Species
Horses
Manufacturer
Veterinary Immunogenics Ltd
VMD MA No.
18513/5001
What it's used for
For foals with Failure of Passive Transfer To raise the level of circulating IgG in neonatal foals which have been shown to have low levels (less than 4 g/...
Full indications, dosage and side effects ↓The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.
Paying less for Equine plasma + Rhodococcus...
-
1
Ask your vet for a written prescription
They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
-
2
Fill it at a registered online retailer
The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.
Done — we'll email you when prices land.
Prescription required
Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.
Clinical information
Hypermune-RE Equine Plasma — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.
For foals with Failure of Passive Transfer
To raise the level of circulating IgG in neonatal foals which have been shown to have low
levels (less than 4 g/l). The raised level has been demonstrated approximately 24 hours
after administration but the duration of the effect is not known.
For foals with Normal passive Transfer
To raise the level of antibodies. The raised level has been
demonstrated approximately 24 hours after administration and raised levels though
declining generally last for up to 21 days.
Revised: November 2025
MA split from NI Expiry following AN: 02237/2025
To raise the level of circulating IgG in neonatal foals which have been shown to have low
levels (less than 4 g/l). The raised level has been demonstrated approximately 24 hours
after administration but the duration of the effect is not known.
For foals with Normal passive Transfer
To raise the level of antibodies. The raised level has been
demonstrated approximately 24 hours after administration and raised levels though
declining generally last for up to 21 days.
Revised: November 2025
MA split from NI Expiry following AN: 02237/2025
For foals with Failure of Passive Transfer
Hypermune-RE may be administered to foals from 24 hours to 6 days of age where it has
been shown after testing that they have low levels of serum IgG (less than 4 g/l). The dose
required is one litre for a 50 kg foal (and pro rata, i.e. 20 ml per kg).
A blood sample should be collected from the foal approximately 24 hours later and re-
tested for the level of serum IgG. If this is still low, a further dose may be administered.
This should be given within 24 – 48 hours of the first administration and be given in the
same manner as the first (intravenously, via a blood giving set, over 15 - 20 minutes).
Revised: November 2025
MA split from NI Expiry following AN: 02237/2025
For foals with Normal Passive Transfer
The dose required is one litre for a 50 kg foal (and pro rata, i.e. 20 ml per kg). To sustain
raised levels of circulating antibodies a second dose may be given at
approximately 21 days later. This should be given in the same manner as the first
(intravenously, via a blood giving set, over 15 - 20 minutes).
Method of administration
The required dose is administered via a catheter placed in the jugular vein using a blood
giving set equipped with a mesh filter. The product should be administered slowly,
particularly at the start, and administration should take 15 – 20 minutes. Throughout the
administration, the foal should be monitored for signs of adverse reactions.
Thawing should not take place in a microwave oven. The litre bag of plasma should be
immersed only in warm water at not more than 40 ºC. A water bath such as a sink full of
domestic warm water is ideal. As the plasma thaws and the water cools, more warm water
may be added as required but hot water (not greater than hand hot) must be avoided as it
will damage the proteins. The entire litre of plasma should be brought slowly to body
temperature before use to ensure all the cryoprecipitate is dissolved. Under optimum
conditions this whole process may take 2-2½ hours. Occasionally small amounts of fibrin
may still be seen floating in the plasma. It is not significant but must be filtered out by the
filter in the blood administration set.
Inspect for leakage and if apparent on thawing the entire contents must be discarded.
Hypermune-RE may be administered to foals from 24 hours to 6 days of age where it has
been shown after testing that they have low levels of serum IgG (less than 4 g/l). The dose
required is one litre for a 50 kg foal (and pro rata, i.e. 20 ml per kg).
A blood sample should be collected from the foal approximately 24 hours later and re-
tested for the level of serum IgG. If this is still low, a further dose may be administered.
This should be given within 24 – 48 hours of the first administration and be given in the
same manner as the first (intravenously, via a blood giving set, over 15 - 20 minutes).
Revised: November 2025
MA split from NI Expiry following AN: 02237/2025
For foals with Normal Passive Transfer
The dose required is one litre for a 50 kg foal (and pro rata, i.e. 20 ml per kg). To sustain
raised levels of circulating antibodies a second dose may be given at
approximately 21 days later. This should be given in the same manner as the first
(intravenously, via a blood giving set, over 15 - 20 minutes).
Method of administration
The required dose is administered via a catheter placed in the jugular vein using a blood
giving set equipped with a mesh filter. The product should be administered slowly,
particularly at the start, and administration should take 15 – 20 minutes. Throughout the
administration, the foal should be monitored for signs of adverse reactions.
Thawing should not take place in a microwave oven. The litre bag of plasma should be
immersed only in warm water at not more than 40 ºC. A water bath such as a sink full of
domestic warm water is ideal. As the plasma thaws and the water cools, more warm water
may be added as required but hot water (not greater than hand hot) must be avoided as it
will damage the proteins. The entire litre of plasma should be brought slowly to body
temperature before use to ensure all the cryoprecipitate is dissolved. Under optimum
conditions this whole process may take 2-2½ hours. Occasionally small amounts of fibrin
may still be seen floating in the plasma. It is not significant but must be filtered out by the
filter in the blood administration set.
Inspect for leakage and if apparent on thawing the entire contents must be discarded.
None
It should be noted that ACD-A is an excipient and that excess citrate may cause a reaction
in the recipient foal. This may be seen as muscle fasciculations, weakness and cardiac
abnormalities.
Transfusion Reactions are very rare; signs include tachycardia, hyperventilating and
trembling.
Anaphylaxis
tachycardia, hyperventilating and trembling, or other signs such as colic, pyrexia, cardiac
arrhythmias, urticaria and collapse.
Volume Overload is a rare hazard of plasma transfusion especially if the administration is
carried out in foals compromised in any way or too quickly. Signs include respiratory
distress, hyperventilation, staggering and collapse when in standing restraint. Additionally,
if the foal is in lateral recumbency froth may be seen at the nostril.
Measures to avoid these adverse reactions are detailed in section 4.5.
in the recipient foal. This may be seen as muscle fasciculations, weakness and cardiac
abnormalities.
Transfusion Reactions are very rare; signs include tachycardia, hyperventilating and
trembling.
Anaphylaxis
tachycardia, hyperventilating and trembling, or other signs such as colic, pyrexia, cardiac
arrhythmias, urticaria and collapse.
Volume Overload is a rare hazard of plasma transfusion especially if the administration is
carried out in foals compromised in any way or too quickly. Signs include respiratory
distress, hyperventilation, staggering and collapse when in standing restraint. Additionally,
if the foal is in lateral recumbency froth may be seen at the nostril.
Measures to avoid these adverse reactions are detailed in section 4.5.
It is recommended that appropriate control measures should be
implemented to control disease. Such measures include avoidance of overcrowding,
controlling paddock dust levels, provision of shade for the animals, removal of faeces from
pastures and close monitoring of foal health.
Special precautions for use in animals
•
•
•
Transfusion Reactions. Careful monitoring, especially at the start and throughout the
transfusion is essential. Distinction must be made between reaction to restraint and
catheterisation and signs attributable to transfusion reaction. If tachycardia,
hyperventilating or trembling occurs, the transfusion should be slowed down or stopped
altogether. If signs abate within five minutes, as they should, then the transfusion should
be continued. If they recur again, the transfusion should be stopped entirely.
Anaphylaxis. Careful monitoring, especially at the start and throughout the transfusion, is
essential. If tachycardia, hyperventilating or trembling occurs, the transfusion should be
slowed down or stopped altogether. If signs abate within five minutes, as they should, then
the transfusion should be continued. If they recur again, the transfusion should be stopped
entirely. If severe, or other signs occur such as colic, pyrexia, cardiac arrhythmias, urticaria
and collapse, the transfusion should be stopped and if necessary epinephrine
(0.01 mg/kg), corticosteroids and intravenous saline administered.
drugs should always be on hand. Flunixin meglumine at 0.25 mg/kg may be used
prophylactically to reduce the incidence of side effects.
Volume Overload
the administration is carried out in foals compromised in any way or too quickly. Every foal
should be fully clinically examined prior to transfusion and in the case of compromised
foals the transfusion should be maintained at a slow rate, 1 litre for a 50 kg foal or pro rata
in 1 hour. Careful monitoring throughout the transfusion is essential. If hyperventilating,
respiratory distress or trembling occurs, the transfusion should be slowed down or stopped
altogether. Diuretics may be used in severe cases.
Special precautions to be taken by the person administering the veterinary
medicinal product to animals
Administer only using a blood giving set to minimise risk of self-injection. In case of
accidental contact with skin, wash affected areas thoroughly with warm soapy water.
Revised: November 2025
MA split from NI Expiry following AN: 02237/2025
implemented to control disease. Such measures include avoidance of overcrowding,
controlling paddock dust levels, provision of shade for the animals, removal of faeces from
pastures and close monitoring of foal health.
Special precautions for use in animals
•
•
•
Transfusion Reactions. Careful monitoring, especially at the start and throughout the
transfusion is essential. Distinction must be made between reaction to restraint and
catheterisation and signs attributable to transfusion reaction. If tachycardia,
hyperventilating or trembling occurs, the transfusion should be slowed down or stopped
altogether. If signs abate within five minutes, as they should, then the transfusion should
be continued. If they recur again, the transfusion should be stopped entirely.
Anaphylaxis. Careful monitoring, especially at the start and throughout the transfusion, is
essential. If tachycardia, hyperventilating or trembling occurs, the transfusion should be
slowed down or stopped altogether. If signs abate within five minutes, as they should, then
the transfusion should be continued. If they recur again, the transfusion should be stopped
entirely. If severe, or other signs occur such as colic, pyrexia, cardiac arrhythmias, urticaria
and collapse, the transfusion should be stopped and if necessary epinephrine
(0.01 mg/kg), corticosteroids and intravenous saline administered.
drugs should always be on hand. Flunixin meglumine at 0.25 mg/kg may be used
prophylactically to reduce the incidence of side effects.
Volume Overload
the administration is carried out in foals compromised in any way or too quickly. Every foal
should be fully clinically examined prior to transfusion and in the case of compromised
foals the transfusion should be maintained at a slow rate, 1 litre for a 50 kg foal or pro rata
in 1 hour. Careful monitoring throughout the transfusion is essential. If hyperventilating,
respiratory distress or trembling occurs, the transfusion should be slowed down or stopped
altogether. Diuretics may be used in severe cases.
Special precautions to be taken by the person administering the veterinary
medicinal product to animals
Administer only using a blood giving set to minimise risk of self-injection. In case of
accidental contact with skin, wash affected areas thoroughly with warm soapy water.
Revised: November 2025
MA split from NI Expiry following AN: 02237/2025
Safety and efficacy data are available which demonstrate that Hypermune-RE can be
administered on the same day but not mixed with tetanus antitoxin.
No information is available on the safety and efficacy of Hypermune-RE when used with
any other veterinary medicinal product except the product mentioned above. A decision to
use this product before or after any other veterinary medicinal product therefore needs to
be made on a case by case basis.
As with colostrum derived passive immunity, the passive immunity transferred by
Hypermune-RE may interfere with response to vaccine. It is recommended that this is
considered when starting a vaccine programme with due adherence to the vaccine
manufacturer’s instructions.
administered on the same day but not mixed with tetanus antitoxin.
No information is available on the safety and efficacy of Hypermune-RE when used with
any other veterinary medicinal product except the product mentioned above. A decision to
use this product before or after any other veterinary medicinal product therefore needs to
be made on a case by case basis.
As with colostrum derived passive immunity, the passive immunity transferred by
Hypermune-RE may interfere with response to vaccine. It is recommended that this is
considered when starting a vaccine programme with due adherence to the vaccine
manufacturer’s instructions.
Store in a freezer (-30 °C to -15 °C)
HYPERMUNE-RE should be handled carefully when being unpacked and stored in the
freezer. The outer packaging should not be removed as it protects the brittle frozen plastic
which is susceptible to damage from careless handling such as being dropped or knocked in
the freezer. When thawed it should be stored in a refrigerator.
HYPERMUNE-RE should be handled carefully when being unpacked and stored in the
freezer. The outer packaging should not be removed as it protects the brittle frozen plastic
which is susceptible to damage from careless handling such as being dropped or knocked in
the freezer. When thawed it should be stored in a refrigerator.
Do not use in pregnant or lactating horses.
4.8 Interaction with other medicinal products and other forms of interaction
Safety and efficacy data are available which demonstrate that Hypermune-RE can be
administered on the same day but not mixed with tetanus antitoxin.
No information is available on the safety and efficacy of Hypermune-RE when used with
any other veterinary medicinal product except the product mentioned above. A decision to
use this product before or after any other veterinary medicinal product therefore needs to
be made on a case by case basis.
As with colostrum derived passive immunity, the passive immunity transferred by
Hypermune-RE may interfere with response to vaccine. It is recommended that this is
considered when starting a vaccine programme with due adherence to the vaccine
manufacturer’s instructions.
4.9 Amounts to be administered and administration route
For foals with Failure of Passive Transfer
Hypermune-RE may be administered to foals from 24 hours to 6 days of age where it has
been shown after testing that they have low levels of serum IgG (less than 4 g/l). The dose
required is one litre for a 50 kg foal (and pro rata, i.e. 20 ml per kg).
A blood sample should be collected from the foal approximately 24 hours later and re-
tested for the level of serum IgG. If this is still low, a further dose may be administered.
This should be given within 24 – 48 hours of the first administration and be given in the
same manner as the first (intravenously, via a blood giving set, over 15 - 20 minutes).
Revised: November 2025
MA split from NI Expiry following AN: 02237/2025
For foals with Normal Passive Transfer
The dose required is one litre for a 50 kg foal (and pro rata, i.e. 20 ml per kg). To sustain
raised levels of circulating antibodies a second dose may be given at
approximately 21 days later. This should be given in the same manner as the first
(intravenously, via a blood giving set, over 15 - 20 minutes).
Method of administration
The required dose is administered via a catheter placed in the jugular vein using a blood
giving set equipped with a mesh filter. The product should be administered slowly,
particularly at the start, and administration should take 15 – 20 minutes. Throughout the
administration, the foal should be monitored for signs of adverse reactions.
Thawing should not take place in a microwave oven. The litre bag of plasma should be
immersed only in warm water at not more than 40 ºC. A water bath such as a sink full of
domestic warm water is ideal. As the plasma thaws and the water cools, more warm water
may be added as required but hot water (not greater than hand hot) must be avoided as it
will damage the proteins. The entire litre of plasma should be brought slowly to body
temperature before use to ensure all the cryoprecipitate is dissolved. Under optimum
conditions this whole process may take 2-2½ hours. Occasionally small amounts of fibrin
may still be seen floating in the plasma. It is not significant but must be filtered out by the
filter in the blood administration set.
Inspect for leakage and if apparent on thawing the entire contents must be discarded.
4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary
No information is available on the effects of administering an overdose.
Volume overload in foals
Volume overload is a rare hazard of plasma transfusion especially if the administration is
carried out in foals compromised in any way or too quickly.
4.11 Withdrawal period(s)
Zero days.
5. IMMUNOLOGICAL PROPERTIES
To modulate the immune system by providing equine immunoglobulins, and specific
antibodies to
severity of
with the use of Hypermune RE by the recommended schedule
ATCvet code: QI05AM.
Revised: November 2025
MA split from NI Expiry following AN: 02237/2025
4.8 Interaction with other medicinal products and other forms of interaction
Safety and efficacy data are available which demonstrate that Hypermune-RE can be
administered on the same day but not mixed with tetanus antitoxin.
No information is available on the safety and efficacy of Hypermune-RE when used with
any other veterinary medicinal product except the product mentioned above. A decision to
use this product before or after any other veterinary medicinal product therefore needs to
be made on a case by case basis.
As with colostrum derived passive immunity, the passive immunity transferred by
Hypermune-RE may interfere with response to vaccine. It is recommended that this is
considered when starting a vaccine programme with due adherence to the vaccine
manufacturer’s instructions.
4.9 Amounts to be administered and administration route
For foals with Failure of Passive Transfer
Hypermune-RE may be administered to foals from 24 hours to 6 days of age where it has
been shown after testing that they have low levels of serum IgG (less than 4 g/l). The dose
required is one litre for a 50 kg foal (and pro rata, i.e. 20 ml per kg).
A blood sample should be collected from the foal approximately 24 hours later and re-
tested for the level of serum IgG. If this is still low, a further dose may be administered.
This should be given within 24 – 48 hours of the first administration and be given in the
same manner as the first (intravenously, via a blood giving set, over 15 - 20 minutes).
Revised: November 2025
MA split from NI Expiry following AN: 02237/2025
For foals with Normal Passive Transfer
The dose required is one litre for a 50 kg foal (and pro rata, i.e. 20 ml per kg). To sustain
raised levels of circulating antibodies a second dose may be given at
approximately 21 days later. This should be given in the same manner as the first
(intravenously, via a blood giving set, over 15 - 20 minutes).
Method of administration
The required dose is administered via a catheter placed in the jugular vein using a blood
giving set equipped with a mesh filter. The product should be administered slowly,
particularly at the start, and administration should take 15 – 20 minutes. Throughout the
administration, the foal should be monitored for signs of adverse reactions.
Thawing should not take place in a microwave oven. The litre bag of plasma should be
immersed only in warm water at not more than 40 ºC. A water bath such as a sink full of
domestic warm water is ideal. As the plasma thaws and the water cools, more warm water
may be added as required but hot water (not greater than hand hot) must be avoided as it
will damage the proteins. The entire litre of plasma should be brought slowly to body
temperature before use to ensure all the cryoprecipitate is dissolved. Under optimum
conditions this whole process may take 2-2½ hours. Occasionally small amounts of fibrin
may still be seen floating in the plasma. It is not significant but must be filtered out by the
filter in the blood administration set.
Inspect for leakage and if apparent on thawing the entire contents must be discarded.
4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary
No information is available on the effects of administering an overdose.
Volume overload in foals
Volume overload is a rare hazard of plasma transfusion especially if the administration is
carried out in foals compromised in any way or too quickly.
4.11 Withdrawal period(s)
Zero days.
5. IMMUNOLOGICAL PROPERTIES
To modulate the immune system by providing equine immunoglobulins, and specific
antibodies to
severity of
with the use of Hypermune RE by the recommended schedule
ATCvet code: QI05AM.
Revised: November 2025
MA split from NI Expiry following AN: 02237/2025
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
Medication costs adding up?
Pet insurance can cover prescription medications. Find the right policy for your pet.
Same active ingredient
Other Products Containing Equine plasma
These products share the same active ingredient and may be suitable alternatives. Always consult your vet.
Alternative options to consider
Retailers we earn a commission from. It costs you nothing and never changes what we show.
The Pharm Pet Co.
The Pharm Pet Co. — Pet Pharmacy
UK online pet pharmacy. Flea, worm, prescription medications, supplements and pet food. Save vs vet prices.
Save up to 50%
Shop now
Pharmacy2U
Pet Care at Pharmacy2U
The UK's largest online pharmacy. Pet wormers, flea treatments, dental and joint care. Free delivery on orders over £30.
Free delivery £30+
Shop now
KatKin
KatKin Fresh Cat Food
The UK's top-rated cat food. 100% fresh, human-quality meat, gently cooked and delivered frozen. Vet-formulated for every life stage.
From £1.45/meal
Shop now
We may earn a small commission if you purchase through these links, at no extra cost to you.
Also in other
Related Medications
Alizin 30 mg/ml Solution for Injection for Dogs
POM-VAglepristone
injection
Rx
Dogs
Alizin 30 mg/ml Solution for Injection for Dogs
POM-VAglepristone
injection
Rx
Dogs
Animalintex Hoof Treatment Poultice
AVM-GSLBoric Acid
poultice
Horses
Animalintex Poultice
AVM-GSLBassorin E Powder + Boric Acid
poultice
Dogs
Horses
Bexatil 15 mg Tablets for Cats
POM-VBexagliflozin
tablet
Rx
Cats
Bexatil 15 mg Tablets for Cats
POM-VBexagliflozin
tablet
Rx
Cats
Find cheaper vets near you
Compare vet consultation prices in your area. Save on procedures and get a prescription to buy medications online.