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POM-V Prescription Required Companion Animal

Tetanus Antitoxin Behring Solution for Injection for Horses, Sheep and Dogs

Active ingredients: Clostridium tetani, Equine plasma

Form

Injection

Species

Dogs Horses Sheep

Manufacturer

Intervet International B.V.

VMD MA No.

06376/4140

What it's used for

This veterinary medicinal product is intended for therapeutic use in horses and dogs to enhance recovery rates in animals showing clinical signs of tetanus...

Full indications, dosage and side effects ↓
View official SPC (PDF)

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  1. 1

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Prescription required

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Clinical information

Tetanus Antitoxin Behring Solution for Injection for Horses, Sheep and Dogs — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

This veterinary medicinal product is intended for therapeutic use in horses and dogs to
enhance recovery rates in animals showing clinical signs of tetanus, when combined
with other treatments.
Onset of immunity: After subcutaneous and intramuscular injection: 2 days after
administration.
After intravenous or intramuscular injection to horses: 1 – 4 hours.
After subarachnoidal injection: straight after application.
Duration of immunity: 2 – 3 weeks.
The duration of effective antibody titres has not been investigated in the central
nervous system. The intravenous and subarachnoidal application routes are
recommended for therapeutic use of this veterinary medicinal product in horses only.
I.a Prophylaxis:
Method of administration:
Subcutaneous or intramuscular injection.
Dosage for preoperative treatment or after injury:
Horse7,500 – 10,000 IU = 7.5 – 10 mlFoal with body weight up to 100 kg3,000 IU = 3.0 ml
If the operation wound or the injury has not improved after 10 – 14 days the serum
application has to be repeated (see section 3.4).
Simultaneous with vaccination
Subcutaneous or intramuscular injection.
This veterinary medicinal product and vaccines
*
against tetanus are to be applied at
different parts of the body.
*
Equilis Prequenza Te and Equilis Te. For proper use please refer to the relevant
package leaflets.
Dosage see 'prophylaxis'.
I.b Therapeutic:
Method of administration:
Preferably intravenous injection, otherwise subcutaneous or intramuscular injection.
To supply the central nervous system with antitoxin the administration of this
veterinary medicinal product into the subarachnoid space is recommended (see
section 3.6).
Dosage:
Horse20,000 – 50,000 IU = 20 – 50 mlFoal with body weight up to 100 kg30,000 IU = 30 ml
The given doses should be applied in an as early as possible stage of the disease. A
repeated administration on the two following days can be useful.
II. Dosage and method of administration in sheep
Method of administration:
Subcutaneous application.
The dosage for preoperative treatment or after injury should contain:
Sheep (subcutaneous)3,000 IU = 3.0 mlLamb (subcutaneous)1,500 IU = 1.5 ml
III. Dosage and method of administration in dogs
Method of administration:
Subcutaneous or intramuscular application.
a. The dosage for preoperative treatment or after injury should contain:
Dog depending on the body weight
(80 IU/kg)
Min 500 – max 2,500 IU = 0.5 – 2.5 ml
b. The therapeutical dosage should contain:
Dog depending on the body weight
(1,000 IU/kg)
Min 10,000 – max 20,000 IU = 10 – 20 ml
Administration to cats is contraindicated. Cats are unable to metabolise the
preservative phenol as rapidly as other species due to the absence of a specific
enzyme.
Horses, dogs:
Very rare
(<1 animal / 10,000 animals treated,
including isolated reports):
Injection site swelling
Hyperthermia
Hypersensitivity reaction
1
Transient
Transient. May occur on the day of application and the day after.
Especially after repeated administration. Especially heterologous animals are
susceptible.
Sheep:
Rare
(1 to 10 animals / 10,000 animals
treated):
Hyperthermia
Very rare
(<1 animal / 10,000 animals treated,
including isolated reports):
Injection site swelling
Hypersensitivity reaction
Transient. May occur on the day of application and the day after.
Transient
Especially after repeated administration. Especially heterologous animals are
susceptible.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.
None.

Special precautions for safe use in the target species:
After repeated administration at longer intervals sensitisation may occur, leading to
hypersensitivity reactions/anaphylactic shock. Administering repeat doses at longer
intervals is therefore not recommended. Especially if a (repeated) intravenous
application is intended in heterologous animals a biological pre-testing (1 ml,
subcutaneous, 30 – 40 minutes observation) should be performed.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
None.
Special precautions for the protection of the environment:
Not applicable.
Safety and efficacy data are available which demonstrate that this immunological
veterinary medicinal product can be administered on the same day but not mixed with
Equilis Te and Equilis Prequenza Te (for proper use, refer to the package leaflets).
No information is available on the safety and efficacy of this immunological veterinary
medicinal product when used with any other veterinary medicinal product except the
products mentioned above. A decision to use this immunological veterinary medicinal
product before or after any other veterinary medicinal product therefore needs to be
made on a case by case basis.
Store in a refrigerator (2 °C – 8 °C).
Do not freeze.
Protect from light.
Zero days.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.

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