Hyogen Emulsion for Injection for Pigs
Active ingredient: Mycoplasma hyopneumoniae
Form
Injection
Species
Manufacturer
Ceva Sante Animale
VMD MA No.
14966/3049
What it's used for
Onset of immunity: 3 weeks after vaccination Duration of immunity: 26 weeks after vaccination
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Prescription required
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Hyogen Emulsion for Injection for Pigs — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.
Duration of immunity: 26 weeks after vaccination
Use sterile syringe and needle, respect aseptic conditions of vaccination.
When Hyogen is used alone:
Vaccinate pigs in the side of their neck.
Administer a single dose of 2 ml from 3 weeks of age.
When Hyogen is mixed with Circovac:
The mixed use is restricted to the 100 doses (200 ml) presentations of Hyogen and to
the 100 doses presentations (50 ml of reconstituted vaccine) of Circovac.
Piglets from 3 weeks of age:
HyogenCircovac
100 doses (200 ml of vaccine) in
250 ml bottle
100 doses for piglets (50 ml of
reconstituted suspension +
emulsion)
Vaccine devices should be used under aseptic conditions and in accordance with the
device instructions provided by the manufacturer.
Prepare Circovac by vigorously shaking the vial of antigen suspension and injecting
its content into the vial of emulsion containing adjuvant.
Mix 200 ml of Hyogen and 50 ml of Circovac and shake gently until a homogeneous
white emulsion is obtained.
Administer one 2.5 ml dose of the mixture by intramuscular injection, in the side of
the neck.
Use the entire vaccine mixture immediately after mixing.
Very common
(>1 animal / 10 animals
treated):
Elevated temperature
Injection site swelling
Uncommon
(1 to 10 animals / 1,000 animals
treated):
Hypersensitivity reaction
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Anaphylactic shock
1
Increase in body temperature (average 1.3 °C, in individual pigs up to 2 °C) on the
day of vaccination, which resolves within one day.
A local injection site swelling up to 5 cm in diameter, lasting up to three days. These
reactions do not need further treatment.
Immediate mild hypersensitivity-like reactions after vaccination, resulting in transient
clinical signs such as vomiting.
Serious anaphylactic-type reactions (shock, recumbency) which may be fatal. Such
reactions require prompt symptomatic treatment.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or the national competent authority via the
national reporting system. See the package leaflet for respective contact details.
The data available are not sufficient to exclude the interaction of maternally derived
antibodies against with vaccine uptake. Interaction with
maternally derived antibodies is known and should be taken into consideration. It is
recommended to delay vaccination in piglets with residual MDA against
hyopneumoniae at the age of 3 weeks.
Special precautions for safe use in the target species:
Not applicable
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
In case of accidental self-injection, seek medical advice immediately and show the
package leaflet or the label to the physician.
To the user:
This veterinary medicinal product contains mineral oil. Accidental injection/self-
injection may result in severe pain and swelling, particularly if injected into a joint or
finger, and in rare cases could result in the loss of the affected finger if prompt
medical attention is not given. If you are accidentally injected with this veterinary
medicinal product, seek prompt medical advice even if only a very small amount is
injected and take the package leaflet with you. If pain persists for more than 12 hours
after medical examination, seek medical advice again.
To the physician:
This veterinary medicinal product contains mineral oil. Even if small amounts have
been injected, accidental injection with this veterinary medicinal product can cause
intense swelling, which may, for example, result in ischaemic necrosis and even the
loss of a digit. Expert, PROMPT, surgical attention is required and may necessitate
early incision and irrigation of the injected area, especially where there is involvement
of finger pulp or tendon.
Special precautions for the protection of the environment:
Not applicable.
mixed with Circovac and administered to piglets at one injection site. Vaccinate
piglets from 3 weeks of age.
Onset of immunity: 3 weeks after vaccination when mixed with Circovac
Duration of immunity: 23 weeks when mixed with Circovac.
In case of mixing with Circovac, slight and transient local reactions may occur very
commonly after the administration, mainly swelling (0.5 cm - 5 cm), mild pain and
redness as well as in some cases oedema. These reactions resolve spontaneously
within maximum 4 days. Transient lethargy may occur very commonly on the day of
vaccination which resolves spontaneously within 1-2 days. An increase in individual
rectal temperature of up to 2.5 °C may occur commonly lasting less than 24 hours.
The above adverse reactions were observed in clinical studies.
The product literature of Circovac should be consulted before mixed administration.
No information is available on the safety and efficacy of this vaccine when used with
any other veterinary medicinal product, except when mixed with Circovac. A decision
to use this vaccine before or after any other veterinary medicinal product therefore
needs to be made on a case by case basis.
Do not freeze.
Protect from light.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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Other Products Containing Mycoplasma hyopneumoniae
These products share the same active ingredient and may be suitable alternatives. Always consult your vet.
Cirbloc M Hyo Emulsion for Injection for Pigs
POM-VCeva-Phylaxia Veterinary Biologicals Co. Ltd
Cirbloc M Hyo Emulsion for Injection for Pigs
POM-VCeva Animal Health Ltd
CircoMax Myco Emulsion for Injection for Pigs
POM-VZoetis UK Limited
CircoMax Myco Emulsion for Injection for Pigs
POM-VZoetis Belgium
Hyogen Emulsion for Injection for Pigs
POM-VCeva Sante Animale
Ingelvac MycoFlex Suspension for Injection for Pigs
POM-VBoehringer Ingelheim Vetmedica GmbH
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