POM-V Prescription Required

Gabbrovet Multi 140 mg/ml Solution for Use in Drinking Water/Milk for Pre-ruminant Cattle and Pigs

Active ingredient: Paromomycin Sulfate

Form

Solution

Species

Cattle Pigs

Manufacturer

Ceva Sante Animale

VMD MA No.

14966/5083

What it's used for

Pre-ruminant cattle: Colibacillosis Treatment of gastro-intestinal infections caused by Escherichia coli susceptible to paromomycin. Cryptosporidiosis Trea...

Full indications, dosage and side effects ↓

View official SPC (PDF)

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Paying less for Paromomycin Sulfate

1

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2

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Clinical information

Gabbrovet Multi 140 mg/ml Solution for Use in Drinking Water/Milk for Pre-ruminant Cattle and Pigs — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

Pre-ruminant cattle:
Colibacillosis
Treatment of gastro-intestinal infections caused by Escherichia coli susceptible to
paromomycin.
Cryptosporidiosis
Treatment of infections caused by diagnosed Cryptosporidium parvum, by reduction
of diarrhoea and reduction of faecal oocyst shedding. Administration has to start
within 24 hours after the onset of diarrhoea.

Revised: November 2025
AN: 01837/2025
Pigs:
Colibacillosis
Treatment of gastro-intestinal infections caused by Escherichia coli susceptible to
paromomycin.

Oral use.
To ensure a correct dosage bodyweight should be determined as accurately as
possible.
Cattle (pre-ruminant cattle):
Colibacillosis
Duration of treatment: 3-5 days.
Administration in milk/milk replacer.
Recommended dosage: 1.25 – 2.5 ml of veterinary medicinal product/10 kg BW/day,
equivalent to 17500 - 35000 IU of paromomycin per kg BW/day (i.e. approximately
25-50 mg paromomycin sulfate per kg BW/day).
Cattle (newborn calves):
Cryptosporidiosis
Duration of treatment: 5 days.
Administration in milk/milk replacer or directly in the mouth using either a syringe or
an appropriate device for oral administration.
Recommended dosage: 7.5 ml of veterinary medicinal product/10 kg BW/day for 5
consecutive days, i.e. 105000 IU of paromomycin per kg BW/day for 5 consecutive
days (i.e. approximately 150 mg paromomycin sulfate per kg BW/day).
In case of insufficient uptake of milk, the totality of the remaining solution should be
administered orally directly into the mouth of the animal.
Pigs:
Colibacillosis
Duration of treatment: 3-5 days.
Administration in drinking water.
Recommended dosage: 1.25 – 2 ml of veterinary medicinal product/10 kg BW/day,
equivalent to 17500 - 28000 IU of paromomycin per kg BW/day (i.e. approximately
25-40 mg paromomycin sulfate per kg BW/day).

Revised: November 2025
AN: 01837/2025
For the administration through the drinking water the exact daily amount of veterinary
medicinal product should be based on the number of the animals to be treated, and
the recommended dose calculated according to the following formula:
ml product/ kg BW/day x Mean bodyweight (kg)
of animals to be treated ml product per litre
_ = drinking water/day/ animal/
Mean daily water consumption (litre) per animal
The uptake of medicated water depends on several factors including clinical
conditions of the animals and the local conditions such as ambient temperature and
humidity. In order to obtain the correct dosage, uptake of drinking water has to be
monitored and the concentration of paromomycin has to be adjusted accordingly.
Medicated drinking water/milk/milk replacer and any stock solutions should be freshly
prepared every 6 hours (in milk/milk replacer) or every 24 hours (in water).

Do not use in animals with known hypersensitivity to paromomycin, other
aminoglycosides or any of the excipients.
Do not use in cases with impaired function of the kidneys or liver.
Do not use in ruminating animals.
Do not use in turkeys due to the risk of selection for antimicrobial resistance in
intestinal bacteria.

In rare occasions soft faeces have been observed.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports)

Revised: November 2025
AN: 01837/2025
Aminoglycoside antibiotics such as paromomycin can cause oto- and nephrotoxicity.

Cross-resistance has been shown between paromomycin and neomycin in
Enterobacterales. Use of the product should be carefully considered when
susceptibility testing has shown resistance to aminoglycosides because its
effectiveness may be reduced.”
Treatment with the veterinary medicinal product reduced the impact of
cryptosporidiosis on the daily bodyweight gain.

Special precautions for use in animals
The use of the veterinary medicinal product should be combined with good
management practices e.g. good hygiene, proper ventilation, no overstocking.
Since the product is potentially ototoxic and nephrotoxic, it is recommended to
assess kidney function. Special care should be taken when considering
administration of the veterinary medicinal product to newborn animals due to the
known higher gastrointestinal absorption of paromomycin in neonates. This higher
absorption could lead to an increased risk of oto-and nephrotoxicity. The use of the
veterinary medicinal product in calves of 5 days or less should be based on benefit-
risk assessment by the responsible veterinarian.
As with any antiparasiticide, frequent and repeated use of antiprotozoals from the
same class may lead to the development of resistance.
Use of the product should be in accordance with official, national and regional
antimicrobial policies.
Use of the product should be based on identification and susceptibility testing of the
target pathogen(s). If this is not possible, therapy should be based on epidemiological
information and knowledge of susceptibility of the target pathogens at farm level, or
at local/regional level.
Colibacillosis
The uptake of medication by animals can be altered as a consequence of illness. In
case of insufficient uptake of water/milk animals should be treated parenterally using
a suitable injectable veterinary medicinal product following the advice of the
veterinarian.

Revised: November 2025
AN: 01837/2025
Prolonged or repeated use of the veterinary medicinal product should be avoided by
improving management practices and through cleansing and disinfection.
Use of the veterinary medicinal product deviating from the given instructions may
increase the prevalence of bacteria resistant to paromomycin and may decrease the
effectiveness of treatment with aminoglycosides due to the potential for cross-
resistance.
Aminoglycosides are considered as critical in human medicine. Consequently, they
should not be used as a first intention antimicrobial treatment in veterinary medicine.
Cryptosporidiosis
Calves should only receive the treatment upon confirmation of cryptosporidial oocysts
in their faeces.
The product should only be used in individual animals.
Do not use on an empty stomach. For treatment of anorexic calves, the product
should be administered in half a litre of an electrolyte solution. The animals should
receive enough colostrum according to good breeding practice.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
-
allergic reactions in some people.
-
aminoglycosides and/or benzyl alcohol should avoid contact with the
veterinary medicinal product.
-
eyes.
-
impervious gloves should be worn when handling the veterinary medicinal
product.
-
water.
-
should seek medical advice and show the physician this warning. Swelling of
the face, lips and eyes or difficulty in breathing are more serious symptoms
and require urgent medical attention.
-
product.
-
immediately and show the label to the physician.
-

General anaesthetics and muscle relaxing products increase the neuro-blocking
effect of aminoglycosides. This may cause paralysis and apnoea.
Do not use concurrently with strong diuretics and potentially oto- or nephrotoxic
substances.

125 ml and 250 ml bottles:
Do not store above 25°C
500 ml and 1000 ml bottles:
No special storage conditions required
All Presentations:
After first opening, keep the bottle tightly closed.

Cattle (pre-ruminant cattle and newborn calves):
- Colibacillosis:Dosage: 25-50 mg/kg/day for 3 to 5 days. Meat and offal: 20 days
- Cryptosporidiosis: Dosage: 150 mg/kg/day for 5 days. Meat and offal: 110 days
Pigs:
Meat and offal: 3 days
Due to the accumulation of paromomycin in the liver and kidneys, any repeated
courses of treatment during the withdrawal period should be avoided.
5.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.