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POM-VPS Prescription Required

Fly Off 12.5 mg/ml Pour-on Solution for Sheep

Active ingredient: Cypermethrin Cis 80:Trans 20

Form

Spot-on

Species

Sheep

Manufacturer

Bimeda Animal Health Limited

VMD MA No.

50146/4019

What it's used for

persistent efficacy of 10 weeks (the majority of ticks killed within 3 hours) and treatment of biting lice in sheep. For the prevention and treatment of bl...

Full indications, dosage and side effects ↓
View official SPC (PDF)

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Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Fly Off 12.5 mg/ml Pour-on Solution for Sheep — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

persistent efficacy of 10 weeks (the majority of ticks killed within 3 hours) and treatment
of biting lice in sheep. For the prevention and treatment of blowfly strike in sheep.
On completion of each treatment cycle of the veterinary medicinal product and before the
dosing gun is stored, immediately expel any remaining veterinary medicinal product in
the dosing gun.
To ensure administration of a correct dose, body weight should be determined as
accurately as possible; accuracy of the dosing device should be checked.
AN: 03164/2024 & 03165/2024
Administer by means of the recommended applicator gun as follows:
Blowflies:
Prevention of blowfly strike
Bodyweight Dose Doses per litre
Up to 25 kg* 20 ml 50
25 to 40 kg 30 ml 33
Over 40 kg 40 ml 25
*Do not administer to animals of less than 12.5 kg bodyweight.
The dose should be limited to a maximum dose of 40 ml per animal
Apply as a fan-spray to the surface of the fleece on the back and hindquarters of the
sheep using the Pour-On Gun fitted with the fan-spray nozzle. Half the dose should be
applied to the shoulders, back and flanks, and half to the rump. The distance between
the nozzle and the fleece should be approximately 20 cm. Each dose will require 2 or 3
sweeps to apply. The distance between the nozzle and the fleece should be
approximately 20 cm. Each dose will require 2 or 3 sweeps to apply.
THE VETERINARY MEDICINAL PRODUCT WILL PREVENT BLOWFLY STRIKE ONLY
ON AREAS COVERED BY SPRAY. One application will give 6-8 weeks protection.
Treatment of blowfly strike
Apply directly to all the affected parts at the rate of 2.5 ml per 100 –150 cm
(roughly the
size of a hand). The T-bar nozzle should be used. Most strikes will require 5-10 ml.
Ensure that all affected parts are treated. A single application is sufficient to ensure that
larvae are expelled and killed within a few hours.
AN: 03164/2024 & 03165/2024
Lice: 5 ml per 20 kg bodyweight up to a maximum of 20 ml.
Bodyweight Dose Doses per litre
Up to 20 kg 5 ml 200
21 to 40 kg 10 ml 100
41 to 60 kg 15 ml 66
Over 60 kg 20 ml 50
Using the straight nozzle on the applicator gun, apply as a pin-stream from the shoulders
to the rump along the middle of the backline.
Sheep may be treated off-shears or at any time during the year.
Ticks: Adult sheep and lambs greater than 10 kg: 10 ml per 20 kg bodyweight, up to a
maximum of 40 ml. One treatment will give 10 weeks cover.
Lambs under 10 kg: 5 ml followed 3 weeks later by a 10 ml application.
Bodyweight Dose Doses per litre
Up to 10 kg 5 ml 200
11 to 20 kg 10 ml 100
21 to 40 kg 20 ml 50
41 to 60 kg 30 ml 33
Over 60 kg 40 ml 25
Using the straight nozzle on the Pour-On Gun, apply as a pin-stream from the crown of
the head (see section 3.5 regarding avoidance of the eyes) to the top of the rump.
AN: 03164/2024 & 03165/2024
Headflies: 5 ml per animal irrespective of size.
Apply to the top of the head between the ears using the T-bar nozzle.
Take care not to apply veterinary medicinal product in the sheep’s eyes.
One application before the start of the headfly season will give up to 4 weeks protection
This veterinary medicinal product contains a blue dye to aid in the identification of treated
animals. The colour is temporary and will fade from the fleece within 48 hours of
application.
Not to be used in lambs less than one week old.
Avoid treating very young lambs if the weather is unseasonably hot.
For the prevention of blowfly strike; do not administer to animals of less than 12.5 kg
bodyweight.
Do not use in cases of hypersensitivity to the active substance or to any of the excipients.
AN: 03164/2024 & 03165/2024
None known.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.
Frequent and repeated use of antiparasiticides from the same class may increase risk of
development of resistance.

Special precautions for safe use in the target species:
Care must be taken not to apply the veterinary medicinal product right to the lamb’s tail,
as a ewe recognises a young lamb partly by the smell of the tail area.
Blowflies are attracted by dirty, damp wool or open wounds. The most common site for
fly strike is the rump due to soiling caused by diarrhoea and urine staining. The efficacy
of the veterinary medicinal product is reduced in the presence of soiled or dirty wool.
Therefore, sheep must be crutched (dagged) regularly and appropriate worm control
measures employed.
Take care not to apply veterinary medicinal product in the sheep’s eyes. This precaution
should be observed particularly when treating breeds with little wool on their heads.
Full operating and maintenance instructions, including details on the use of nozzles, are
supplied with each Pour-On Gun. Please read carefully before use. Maintain gun
carefully to ensure accurate dosage.
For external use only.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
The veterinary medicinal product is harmful if swallowed.
Do not eat, drink or smoke whilst using the veterinary medicinal product. Wash hands
immediately after use.
In case of accidental ingestion or mouth contact, immediately rinse the mouth with plenty
of water and seek medical advice.
The veterinary medicinal may cause skin, eye or respiratory irritation, and may cause
hypersensitivity reactions.
Avoid skin and/or eye contact.
Use in a well-ventilated area and avoid inhaling the vapour.
Wear a disposable face-mask when applying as a fan-spray for the prevention of blowfly-
strike.
Wear eye protection, protective clothing, rubber gloves and boots when applying the
veterinary medicinal product and handling the animal until the veterinary medicinal
product has dried.
Make sure when attaching the recommended applicator gun onto the container that the
coiled retainer is secured onto the cap and the applicator.
Remove contaminated clothing immediately and wash exposed skin with plenty of clean
water.
AN: 03164/2024 & 03165/2024
Wash splashes from skin and eyes immediately with plenty of clean water. If irritation
persists seek medical advice immediately and show the package leaflet to the physician.
Avoid children from getting access to the veterinary medicinal product or treated animals.
Special precautions for the protection of the environment:
Cypermethrin is extremely toxic to aquatic and dung organisms
As a precautionary measure sheep must be kept away from watercourses for at least 12
hours following treatment.
Long term effects on dung insects caused by continuous or repeated use of pyrethroid
ectoparasiticides cannot be excluded.
Given the risks to the environment the use of the veterinary medicinal product should be
limited to one treatment per year per pasture.
The veterinary medicinal product must be applied only with the recommended applicator
gun, as the veterinary medicinal product may have a detrimental effect on certain
components of conventional dosing guns.
Do not store above 25°C.
Protect from direct sunlight.
Store in tightly closed original container.
Store away from food, drink and animal feeding stuffs.
Meat and offal: 8 days.
Not to be administered to animals producing milk for human consumption including non-
lactating ewes in the dry period.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.

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