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POM-V Prescription Required Companion Animal

Felpreva Spot-on Solution for Large Cats (> 5.0 – 8.0 kg)

Active ingredients: Emodepside, Praziquantel, Tigolaner

Form

Spot-on

Species

Cats

Manufacturer

Vetoquinol SA

VMD MA No.

06462/5018

What it's used for

medicinal product is exclusively indicated when ectoparasites, cestodes and nematodes are targeted at the same time. Ectoparasites •Ctenocephalides felis)...

Full indications, dosage and side effects ↓
View official SPC (PDF)

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Prescription required

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Clinical information

Felpreva Spot-on Solution for Large Cats (> 5.0 – 8.0 kg) — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

medicinal product is exclusively indicated when ectoparasites, cestodes and nematodes
are targeted at the same time.
Ectoparasites
•Ctenocephalides felis) and tick (Ixodes ricinus, Ixodes
holocyclus) infestations in cats providing immediate and persistent killing
activity for 13 weeks.
•
strategy for the control of flea allergy dermatitis (FAD).
•Notoedres
cati
•Otodectes cynotis
Gastrointestinal roundworms (nematodes) For the treatment of infections with:
•
•
•
Lungworms (nematodes)
For the treatment of infections with:
•
•
Tapeworms (cestodes)
For the treatment of tapeworm infections:
•
•
To ensure a correct dosage, body weight should be determined as accurately as possible.
Posology
The recommended minimum doses are 14.4 mg tigolaner / kg body weight, 3 mg
emodepside/ kg body weight, 12 mg praziquantel / kg body weight equivalent to 0.148
ml product / kg body weight.
Body
Weight
of Cat
(kg)
Applicator size to be
used:
Felpreva spot-on
solution
Volume of
unit (ml)
Tigolaner
(mg/kg bw)
Emodepsid
e (mg/kg
bw)
Praziquant
el
(mg/kg bw)
1.0 - 2.5for small cats0.3714.5 – 36.23.0 – 7.512.0 – 30.12.6 - 5.0for medium cats0.7414.5 – 27.93.0 – 5.812.0 – 23.25.1 - 8.0for large cats1.1814.4 – 22.73.0 – 4.712.0 – 18.8> 8.0 Use an appropriate combination of applicators
Treatment schedule
Treatment is only indicated when ectoparasites, cestodes and nematodes are targeted at
the same time. In the absence of mixed infections or risk of mixed infections, appropriate
narrow spectrum antiparasitic products should be used.
Fleas and ticks
The veterinary medicinal product remains active against fleas and ticks for a period of
13 weeks.
If re-treatment is necessary within 13 weeks after administration, an appropriate
narrow-spectrum product should be used.
Mites
For the treatment of ear mites (Otodectes cynotis) Notoedres cati)
a single dose of the veterinary medicinal product should be administered.
The treatment success and the need for re-treatment with an appropriate narrow- spectrum
antiparasitic product should be determined by the treating veterinarian after 4 weeks.
Due to individual cases of single surviving ear mites and, therefore, the risk of a new cycle
of otocariosis, the treatment success should be confirmed by the veterinarian 1 month
after treatment.
Gastrointestinal nematodes and tapeworms
For the treatment of roundworms and tapeworms a single dose of the veterinary medicinal
product should be administered. The need for and frequency of re- treatment should be
in accordance with the advice of the prescribing veterinarian and take into account the
local epidemiological situation as well as the cat’s lifestyle.
If a re-treatment is necessary within 3 months after administration, an appropriate narrow-
spectrum product should be used.
Lungworms
For treatment against the lungworm
brevior, one treatment with the veterinary medicinal product followed by a second
treatment two weeks apart with a spot-on solution for cats containing 21.4 mg/ml
emodepside and 85.8 mg/ml praziquantel is recommended as there is no veterinary
medicinal product containing only emodepside as active substance.
Method of administration
Use scissors (1) to open the childproof blister. Pull foils apart (2) and remove spot-on
applicator from package (3).
Hold applicator in upright position (4), twist and pull off cap (5) and use the opposite
end of the cap to break the seal (6).
Part the fur on the cat’s neck at the base of the skull until the skin is visible (7). Place
the tip of the applicator on the skin and squeeze firmly several times to empty the
contents directly onto the skin (7). Application on the base of the skull will 6inimize the
ability of the cat to lick the product off.
Do not use in cases of hypersensitivity to the active substances or to any of the excipients.
Cats:
Common
(1 to 10 animals / 100 animals
treated):
Hair standing on end
Rare (1 to 10 animals / 10 000
animals treated):
Application site reaction (e.g. scratching, erythema,
hair loss, inflammation)
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Digestive tract disorders (e.g. hypersalivation,
vomiting)
2,3
Neurological disorders (e.g. ataxia, tremor)
Agitation
, Vocalisation
Inappetence
1

Temporary reaction at the application site
Mild and transient
These signs are thought to occur as a result of the cat licking the application site
immediately after treatment
In individual cases, non-specific signs which can accompany other signs listed
Reporting adverse events is important. It allows continuous safety monitoring of
veterinary medicinal products. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or the national competent authority via the
national reporting system. See the package leaflet for respective contact details.
Ectoparasites need to start feeding on the host to become exposed to tigolaner; therefore,
the risk of the transmission of vector borne diseases cannot be excluded.
Parasite resistance to any particular class of antiparasitics included in the fixed
combination may develop following frequent, repeated use of antiparasitics of those
classes under specific circumstances. The use of this veterinary medicinal product should
be based on the assessment of each individual case and on local epidemiological
information about the current susceptibility of the target species in order to limit the
possibility of a future selection for resistance.
Shampooing or immersion of the animal in water directly after treatment may reduce the
efficacy of the product. Treated animals, therefore, should not be bathed until the solution
has dried.

Special precautions for safe use in the target species:
In the absence of available data, treatment of kittens under 10 weeks of age or weighing
less than 1 kg is not recommended.
This veterinary medicinal product is for topical use and should not be administered in any
other way e.g. orally.
Apply only onto intact skin. Apply as described in section 3.9 to prevent the animal from
licking and ingesting the veterinary medicinal product. Avoid the treated cat or other cats
in the household licking the site of application while it is wet. For signs observed after oral
ingestion (e.g. licking) please refer to section
Emodepside is a substrate for P-glycoprotein. Co-treatment with other substances that
are P-glycoprotein substrates/inhibitors (for example, ivermectin and other antiparasitic
macrocyclic lactones, erythromycin, prednisolone and cyclosporine) could give rise to
pharmacokinetic drug interactions.
This veterinary medicinal product does not require any special temperature storage
conditions.
Keep the applicator in the aluminium blister in order to protect from moisture.
Not applicable.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.

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