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AVM-GSL Over the Counter Companion Animal

Eziflea 400 mg Spot-on Solution for Extra Large Dogs

Active ingredient: Imidacloprid

Form

Spot-on

Species

Dogs

Manufacturer

Chanelle Pharmaceuticals Manufacturing Ltd

VMD MA No.

08749/3137

What it's used for

Fleas on dogs are killed within one day following treatment. One treatment prevents further flea infestation for four weeks.

Full indications, dosage and side effects ↓
View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for Imidacloprid

  1. 1

    Ask your vet for a written prescription

    They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.

  2. 2

    Fill it at a registered online retailer

    The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Clinical information

Eziflea 400 mg Spot-on Solution for Extra Large Dogs — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

Fleas on dogs are killed within one day following treatment. One treatment prevents
further flea infestation for four weeks.
should be weighed accurately prior to treatment.
Dosage and Treatment Schedule
Dog (kg body
weight)
ProductNumber of
Pipettes
Eziflea
(mg/kg body
weight)
From 25 kg to less
than 40 kg
Eziflea 400 for Dogs 1 x 4.0 mlminimum of 10 40 kg and greaterEziflea 400 for Dogs 2 x 4.0 mlminimum of 10
Re-infestation from emergence of new fleas in the environment may continue to
occur for six weeks or longer after treatment is initiated. More than one treatment
may therefore be required, depending on the level of fleas in the environment. To aid
in environmental challenge, the additional use of a suitable environmental treatment
against adult fleas and their developing stages is recommended.
The product remains effective if the animal becomes wet, for example after swimming
or exposure to heavy rain.
However, in cases of frequent swimming or bathing re-treatment may become
necessary, depending on the presence of fleas in the environment. In these cases do
not re-treat more frequently than once weekly.
In cases of biting louse infestation, a further veterinary examination 30 days after
treatment is recommended as some animals may require a second treatment.
Method of administration:
Apply only to undamaged skin. Hold the pipette upright. Tap the narrow part of the
pipette to ensure the contents remain within the main body of the pipette. Snap back
the tip. The dog should be standing for easy application. The entire contents of the
pipette(s) should be applied evenly to three or four spots all located at different
application sites along the dog’s backline from the shoulder to the base of the tail. At
each spot part the coat until the skin is visible. Place the tip of the pipette on the skin
and gently squeeze to expel a portion of the contents directly onto the skin.
Temporary changes to the coat (clumped/greasy hair) may be noted at the
application site.
Correct application will minimise the opportunity for the animal to lick the product.
Do not treat unweaned puppies of less than 8 weeks of age.
Do not use in case of hypersensitivity to the active substance or to any of the
excipients.
Dogs:
Very rare
(<1 animal / 10 000 animals treated,
including isolated reports):
Agitation
Hypersalivation
Disorientation, Neurological signs (e.g.
Depression, Incoordination, Tremor)
Application site reaction (e.g. Hair loss,
Itching, Reddening of the skin, Skin
lesion)
May occur if the dog licks the application site immediately after treatment due to the
bitter taste. This is not a sign of intoxication and disappears within some minutes
without treatment.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or the national competent authority via the
national reporting system. See the package leaflet for respective contact details.
This product is for topical use and should not be administered orally.
Care should be taken to avoid the contents of the pipette coming into contact with the
eyes or mouth of the recipient animal.
Do not allow recently treated animals to groom each other.

Special precautions for safe use in the target species:
If signs of disease persist or appear, consult a veterinary surgeon.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
This product can cause mucous membrane, skin and eye irritation.
Therefore, contact of the product with mouth, skin and eyes should be avoided.
This product contains benzyl alcohol and may cause skin sensitisation or transient
skin reactions in rare cases (for example, irritation, tingling).
People with a known hypersensitivity (allergy) to insecticides or alcohol should avoid
contact with the product.
Do not smoke, drink or eat during application.
If contact with the skin occurs, wash hands with soap and water.
If the product gets into eyes, the eyes should be thoroughly rinsed with clean water. If
skin or eye irritation persists, or the product is accidentally swallowed, seek medical
advice.
Do not stroke, groom or play with treated animals until the application site is dry. It is
therefore recommended that animals are not treated during the day, but should be
treated during the early evening, and that recently treated animals are not allowed to
sleep with owners, especially children.
Dispose of used pipettes immediately.
Wash hands after use.
Special precautions for the protection of the environment:
Imidacloprid is toxic to aquatic organisms. To avoid adverse effects on aquatic
organisms, treated dogs should not be allowed to enter surface water for 48 hours
after treatment.
Do not use simultaneously with other flea products which are applied directly onto the
animal.
This veterinary medicinal product does not require any special storage conditions.
Not applicable

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.

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