Enroxil 50 mg/ml Solution for Injection for Calves, Pigs and Dogs
Active ingredient: Enrofloxacin
Form
Injection
Species
Manufacturer
KRKA, d.d., Novo mesto
VMD MA No.
01656/5068
What it's used for
Calves: Treatment of infections of the respiratory tract caused by enrofloxacin susceptible strains of Pasteurella multocida, Mannheimia haemolytica and My...
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Enroxil 50 mg/ml Solution for Injection for Calves, Pigs and Dogs — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.
Treatment of infections of the respiratory tract caused by enrofloxacin susceptible strains
of Pasteurella multocida, Mannheimia haemolytica and Mycoplasma spp.
Treatment of infections of the alimentary tract caused by enrofloxacin susceptible strains
of Escherichia coli.
Treatment of septicaemia caused by enrofloxacin susceptible strains of Escherichia coli.
Treatment of acute mycoplasma-associated arthritis due to enrofloxacin susceptible
strains of Mycoplasma bovis.
Pigs:
Treatment of infections of the respiratory tract caused by enrofloxacin susceptible strains
of Pasteurella multocida, Mycoplasma spp. and Actinobacillus pleuropneumoniae.
Treatment of infections of the alimentary tract caused by enrofloxacin susceptible strains
of Escherichia coli.
Treatment of septicaemia caused by enrofloxacin susceptible strains of Escherichia coli.
Dogs:
Treatment of infections of the alimentary, respiratory and urogenital tracts (including
prostatitis, adjunctive antibiotic therapy for pyometra), skin and wound infections, otitis
(externa/media) caused by enrofloxacin susceptible strains of spp.,
Revised: May 2024
AN: 00506/2023
Escherichia coli, spp., spp., spp., spp. and
Proteus spp.
Repeated injections should be made at different injection sites.
To ensure a correct dosage, body weight should be determined as accurately as possible.
Calves:
5 mg of enrofloxacin/kg bw, corresponding to 1 ml/10 kg bw, once daily for 3-5 days.
Acute mycoplasma-associated arthritis due to enrofloxacin susceptible strains of
Mycoplasma bovis: 5 mg of enrofloxacin/kg bw, corresponding to 1 ml/10 kg bw, once
daily for 5 days.
The veterinary medicinal product can be administered by slow intravenous or
subcutaneous administration.
Not more than 10 ml should be administered at one subcutaneous injection.
Pigs:
2.5 mg of enrofloxacin/kg bw, corresponding to 0.5 ml/10 kg bw, once daily by
intramuscular injection for 3 days.
Alimentary tract infection or septicaemia caused by : 5 mg of
enrofloxacin/kg bw, corresponding to 1 ml/10 kg bw, once daily by intramuscular injection
for 3 days.
In pigs, the injection should be made in the neck at the ear base.
Not more than 3 ml should be administered at one intramuscular injection site.
Revised: May 2024
AN: 00506/2023
Dogs:
5 mg of enrofloxacin/kg bw, corresponding to 1 ml/10 kg bw, daily by subcutaneous
injection for up to 5 days.
Treatment may be initiated with injectable veterinary medicinal product and maintained
with enrofloxacin tablets. Duration of treatment should be based on the duration of
treatment approved for the appropriate indication in the SPC of the tablet veterinary
medicinal product.
If there is no clinical improvement within two to three days, further susceptibility testing and
possibly a change in antimicrobial therapy should be considered.
Do not exceed the recommended dose.
Normal sterile precautions should be taken.
Do not use in case of resistance against quinolones.
Do not use in case of disturbances in growth of cartilages and/or during injury of
locomotory system particularly on functionally loaded joints or due to body weight loaded
joints.
Do not use in young dogs during their growth, i.e. in small breeds of dogs less than 8
months of age, in big breeds of dogs less than 12 months of age, in giant breeds of dogs
less than 18 months of age, as articular cartilage may be affected during the period of
growth.
Do not use in growing horses because of possible deleterious damage on articular
cartilage.
Do not use in animals that are epileptic or suffer from seizures since enrofloxacin may
cause CNS stimulation.
Do not use in cases of hypersensitivity to the active substance or to any of the excipients.
Very rare
(<1 animal / 10,000 animals treated, including
isolated reports):
Digestive tract disorders (e.g., diarrhoea)
Injection site reaction
1
Generally mild and transient.
May persist up to 14 days.
Pigs:
Very rare
(<1 animal / 10,000 animals treated, including
isolated reports):
Digestive tract disorders (e.g., diarrhoea)
Undetermined frequency
(cannot be estimated from the available
data):
Injection site inflammation
1
Generally mild and transient.
May persist up to 28 days.
Dogs:
Very rare
(<1 animal / 10,000 animals treated, including
isolated reports):
Digestive tract disorders (e.g., diarrhoea)
Undetermined frequency
(cannot be estimated from the available
data):
Injection site reaction (e. g. oedema)
1
Generally mild and transient.
Moderate and transient.
Revised: May 2024
AN: 00506/2023
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See also section 16 of the package
leaflet for respective contact details.
Special precautions for use in animals
Official and local antimicrobial policies should be taken into account when the veterinary
medicinal product is used.
Fluoroquinolones should be reserved for the treatment of clinical conditions which have
responded poorly, or are expected to respond poorly, to other classes of antimicrobials.
Whenever possible fluoroquinolones should only be used based on susceptibility testing.
Use of the veterinary medicinal product including use deviating from the instructions given
in the SPC may increase the prevalence of bacteria resistant to enrofloxacin and may
decrease the effectiveness of treatment with all fluoroquinolones due to the potential for
cross-resistance.
Treatment should not be repeated if an allergic reaction occurs.
Enrofloxacin is partially excreted through the kidney. In the case of the kidney’s functional
failure slower excretion should be taken into account. Special caution should be taken
when using enrofloxacin in animals with impaired renal function.
Degenerative changes of articular cartilage were observed in calves treated orally with 30
mg enrofloxacin/kg bw during 14 days.
The use of enrofloxacin in growing lambs at the recommended dose for 15 days caused
histological changes in the articular cartilage, not associated with clinical signs.
Do not re-inject into the same injection site.
The cap may be safely punctured up to 40 times. When treating groups of animals, use a
draw-off needle.
Only the 50 ml vial should be used to treat dogs and small piglets.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
People with known hypersensitivity to fluoroquinolones should avoid any contact with the
veterinary medicinal product.
Revised: May 2024
AN: 00506/2023
Avoid skin and eye contact. Wash any splashes from skin or eyes immediately with water.
Wash hands after use. Do not eat, drink or smoke whilst handling the veterinary medicinal
product.
Care should be taken to avoid accidental self-injection. In case of accidental self-injection,
seek medical advice immediately and show the package leaflet or the label to the
physician.
Special precautions for the protection of the environment:
Not applicable.
Other precautions
In countries where feeding of fallen stock to scavenger bird populations is permitted as a
conservation measure (see Commission Decision 2003/322/EC), the possible risk to
hatching success should be considered before feeding carcasses of livestock recently
treated with this veterinary medicinal product.
antagonistically to quinolones (e. g. macrolides, tetracyclines or phenicols).
Do not use concurrently with theophylline as the elimination of theophylline may be
delayed.
Care should be taken during the concomitant use of flunixin and enrofloxacin in dogs to
avoid adverse drug reactions. The decrease in drug clearances as a result of co-
administration of flunixin and enrofloxacin indicates that these substances interact during
the elimination phase. Thus, in dogs, the co-administration of enrofloxacin and flunixin
increased the AUC and the elimination half-life of flunixin and increased the elimination
half-life and reduced the Cmax of enrofloxacin.
Intravenous use:
Meat and offal: 5 days.
Subcutaneous use:
Meat and offal: 12 days.
Not authorised for use in animals producing milk for human consumption.
Pigs:
Meat and offal: 13 days.
5.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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