Enrobactin 25 mg/ml Concentrate for Oral Solution for Pet Rabbits, Rodents, Ornamental Birds and Reptiles

Instructions for use
For administration by oral gavage.
The undiluted veterinary medicinal product is strongly alkaline and, therefore, to
avoid caustic effects, it is essential to dilute the product with at least 4 parts water
prior to administration. In the case of smaller animals (weighing less than 500 g), it
may be appropriate to dilute 0.1 ml of the neat product with >4 parts water and
administer a proportion of the total volume.
10 ml bottle: A 1 ml syringe is provided with the 10 ml bottle for withdrawal of small
volumes of the product and to facilitate dilution prior to administration. This syringe
has dosage graduations of 0.01 and 0.1 ml. The lowest volume that has been
demonstrated to be accurate is 0.1 ml. Therefore, for accuracy of dosing, it is
recommended to draw up a minimum of 0.1 ml of product.
30 and 50 ml bottles: A 5 ml syringe is provided for withdrawal of the product.
The diluted solution should be mixed thoroughly prior to administration.
The dilution should be made on a twice-daily basis immediately prior to provision,
preferably in a glass container. Any unused solution should be disposed of
immediately after use.

Revised: February 2021
AN: 01786/2019Page 4 of 7
After extracting and expressing the amount of product required the syringes should
be washed with lukewarm water to remove any remaining product. The syringe can
subsequently be used to prepare another solution or be opened, emptied and left to
dry.
Dosage
Owing to physiological and pharmacokinetic differences between the wide range of
species for which this product is indicated, the dose rates below are for guidance
only. Depending upon the species of animal and the infection to be treated,
alternative doses may be appropriate using an evidence-based approach. However,
any change in dosing regimen should be based on a benefit: risk assessment by the
responsible veterinarian, as tolerance at higher doses has not been investigated. To
ensure a correct dosage body weight should be determined as accurately as possible
to avoid underdosing.
To avoid inhalation of the medication, care should be taken with restraint of the
animal and administration of the product.
Rodents and pet rabbits
5 mg enrofloxacin per kg bodyweight (0.2 ml per kg bodyweight), twice daily for 7
days.
Reptiles
5 mg enrofloxacin per kg bodyweight (0.2 ml per kg bodyweight), at 24-48 hour
intervals

for 6 days.
Reptiles are ectothermic, relying on external heat sources to maintain their body
temperature at the optimum level for correct function of all body systems. Metabolism
of substances and activity of the immune system are, thus, critically dependant on
the body temperature. Therefore, the veterinarian must be aware of correct
temperature requirements of the respective reptile species and the hydration status
of the individual patient. Furthermore, it has to be considered that large differences
exist in the pharmacokinetic behaviour of enrofloxacin among different species,
which additionally will influence the decision about the correct dosage of the
veterinary medicinal product. Therefore, the recommendations made here can only
be used as a starting point for individual dose setting.
Ornamental birds
10 mg enrofloxacin per kg bodyweight (0.4 ml per kg bodyweight), twice daily 7
days.
Treatment should be re-evaluated if no improvement is seen. It is commonly advised
to re-evaluate the treatment if no clinical improvement is observed within 3 days.