DIVENCE IBR MARKER LIVE Lyophilisate and Solvent for Emulsion for Injection
Active ingredient: Infectious bovine rhinotracheitis virus
Form
Injection
Species
Manufacturer
Laboratorios Hipra SA
VMD MA No.
17533/5018
What it's used for
Onset of immunity: 3 weeks after completion of the basic vaccination scheme. Duration of immunity: 6 months after completion of the basic vaccination schem...
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1
Ask your vet for a written prescription
They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
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2
Fill it at a registered online retailer
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Prescription required
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DIVENCE IBR MARKER LIVE Lyophilisate and Solvent for Emulsion for Injection — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.
Duration of immunity:
6 months after completion of the basic vaccination scheme.
1 year after completion of the re-vaccination scheme.
Basic vaccination scheme: administer two doses (2 ml each) with an interval of 3
weeks.
Re-vaccination scheme: one dose of 2 ml should be administered at an interval not
longer than 6 months after completion of the basic vaccination scheme.
Subsequent re-vaccination scheme: one dose of 2 ml should be administered at an
interval not longer than 12 months.
DIVENCE IBR MARKER LIVE may be used for subsequent re-vaccinations after
vaccination with DIVENCE PENTA if there is no further need for protection against
BRSV, PI-3 and BVDV.
The vaccine may be used for subsequent re-vaccinations after vaccination with
DIVENCE TRI vaccine if there is no further need for protection against BRSV and PI-
3, where available.
Method of administration:
Avoid contamination during reconstitution and use. Use only sterile needles and
syringes for administration.
Reconstitute the lyophilisate with the corresponding volume of solvent:
Number of doses per vial of lyophilisateVolume of solvent to be used5 doses10 ml20 doses40 ml40 doses80 ml50 doses100 ml
Peel the top off the aluminium cap on the vial containing the solvent and withdraw 10
ml of volume.
Inject the solvent into the vial containing the lyophilisate.
Shake until the lyophilisate is in emulsion. The 5-doses vial is now ready to use.
For the 20, 40 and 50 doses vials, once the lyophilisate is in emulsion with the 10 ml
of solvent, withdraw all the emulsion obtained from the vaccine vial and inject it into
the vial containing the remaining solvent.
Shake until the lyophilisate is in emulsion.
The reconstituted vaccine is a white-to-yellow emulsion.
Allow the vaccine to reach a temperature of 15 °C – 25 °C before administration.
Very common
(>1 animal / 10 animals treated):
Injection site inflammation
, elevated
temperature
Uncommon
(1 to 10 animals / 1,000 animals
treated):
Anaphylactic-type reaction
.
Milk production decrease
.
Reduced food intake
, Decreased
activity
.
A slight to moderate transient injection site inflammation (up to 14 cm of diameter)
may be observed, which rapidly decreases in diameter within 2 days and subsides
within 2 weeks without treatment.
An elevated temperature (mean increase 1.7 ºC, in individual animals up to 2.4 ºC)
may occur after vaccination. This increase subsided spontaneously within 3 days.
In cases of anaphylactic-type reactions, an appropriate symptomatic treatment
should be administered.
A temporary mild reduction in milk production, feed intake and activity may
uncommonly be observed in dairy cows mostly after the first dose.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian,
to either the marketing authorisation holder or the national competent authority via
the national reporting system. See the package leaflet for respective contact details.
Special precautions for safe use in the target species:
Not applicable.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
To the user:
This veterinary medicinal product contains mineral oil. Accidental injection/self-
injection may result in severe pain and swelling, particularly if injected into a joint or
finger, and in rare cases could result in the loss of the affected finger if prompt
medical attention is not given. If you are accidentally injected with this veterinary
medicinal product, seek prompt medical advice even if only a very small amount is
injected and take the package leaflet with you. If pain persists for more than 12 hours
after medical examination, seek medical advice again.
To the physician:
This veterinary medicinal product contains mineral oil. Even if small amounts have
been injected, accidental injection with this veterinary medicinal product can cause
intense swelling, which may, for example, result in ischaemic necrosis and even the
loss of a digit. Expert, PROMPT, surgical attention is required and may necessitate
early incision and irrigation of the injected area, especially where there is
involvement of finger pulp or tendon.
Special precautions for the protection of the environment:
Not applicable.
any other veterinary medicinal product. A decision to use this vaccine before or after
any other veterinary medicinal product therefore needs to be made on a case by
case basis.
Do not freeze.
Protect from light.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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Other Products Containing Infectious bovine rhinotracheitis virus
These products share the same active ingredient and may be suitable alternatives. Always consult your vet.
Bovilis IBR Marker Inac Suspension for Injection for Cattle
POM-VIntervet International B.V.
DIVENCE IBR MARKER LIVE Lyophilisate and Solvent for Suspension for Injection
POM-VLaboratorios Hipra SA
DIVENCE PENTA Lyophilisate and Solvent for Emulsion for Injection
POM-VLaboratorios Hipra SA
DIVENCE PENTA Lyophilisate and Solvent for Emulsion for Injection
POM-VLaboratorios Hipra SA
Divence Tri Lyophilisate and Solvent for Emulsion for Injection
POM-VLaboratorios Hipra SA
Divence Tri Lyophilisate and Solvent for Emulsion for Injection
POM-VLaboratorios Hipra SA
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