POM-V Prescription Required

DIVENCE PENTA Lyophilisate and Solvent for Emulsion for Injection

Active ingredients: Bovine parainfluenza virus 3, Bovine respiratory syncytial virus, E2 recombinant protein, Infectious bovine rhinotracheitis virus

Form

Injection

Species

Cattle

Manufacturer

Laboratorios Hipra SA

VMD MA No.

17533/5019

What it's used for

BoHV-1: to reduce virus shedding, hyperthermia and clinical signs of IBR (infectious bovine rhinotracheitis). BVDV: to reduce viremia, hyperthermia and leu...

Full indications, dosage and side effects ↓

View official SPC (PDF)

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Clinical information

DIVENCE PENTA Lyophilisate and Solvent for Emulsion for Injection — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

BoHV-1: to reduce virus shedding, hyperthermia and clinical signs of IBR (infectious
bovine rhinotracheitis).
BVDV: to reduce viremia, hyperthermia and leukopenia caused by BVDV-1 and BVDV-2
and virus shedding caused by BVDV-2.
Active immunisation of heifers and cows to reduce from births of persistently infected
calves and transplacental infection of BVDV (type 1 and 2).
Onset of immunity: 3 weeks after completion of the basic vaccination scheme.
Reduction of transplacental infection from BVDV (type 1 and 2) is
achieved 3 weeks after completion of the re-vaccination scheme.
Duration of immunity: 6 months after completion of the basic vaccination scheme.
1 year after completion of the re-vaccination scheme for BoHV-1
and BVDV (type 1 and 2).

For use in cattle from 10 weeks of age onwards.
Basic vaccination scheme: administer two doses (2 ml each) with an interval of 3 weeks.
Re-vaccination scheme: one dose of 2 ml should be administered at an interval not longer
than 6 months after completion of the basic vaccination scheme.
Subsequent re-vaccination scheme: one dose of 2 ml should be administered at an
interval not longer than 12 months.
DIVENCE IBR MARKER LIVE may be used for subsequent re-vaccinations after
vaccination with DIVENCE PENTA if there is no further need for protection against BRSV,
PI-3 and BVDV.
DIVENCE TRI may be used for subsequent re-vaccinations after vaccination with
DIVENCE PENTA if there is no further need for protection against BVDV.
Method of administration:
Avoid contamination during reconstitution and use. Use only sterile needles and syringes
for administration.
Reconstitute the lyophilisate with the entire content of the supplied solvent to obtain an
emulsion for injection.
The reconstituted vaccine is a white-to-yellow emulsion.
Allow the vaccine to reach a temperature of 15 °C – 25 °C before administration.

None.

Cattle:
Very common
(>1 animal / 10 animals treated):
Injection site inflammation
, elevated
temperature
Uncommon
(1 to 10 animals / 1,000 animals treated):
Anaphylactic-type reaction
.
Milk production decrease
.
Reduced food intake
, Decreased
activity
.
A slight to moderate transient injection site inflammation (up to 14 cm of diameter) may
be observed, which rapidly decreases in diameter within 2 days and subsides within 2
weeks without treatment.
An elevated temperature (mean increase 1.7 ºC, in individual animals up to 2.4 ºC) may
occur after vaccination. This increase subsided spontaneously within 3 days.
In cases of anaphylactic-type reactions, an appropriate symptomatic treatment should
be administered.
A temporary mild reduction in milk production, feed intake and activity may uncommonly
be observed in dairy cows mostly after the first dose.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or the national competent authority via the
national reporting system. See the package leaflet for respective contact details.

Vaccinate healthy animals only.

Special precautions for safe use in the target species:
Not applicable.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
To the user:
This veterinary medicinal product contains mineral oil. Accidental injection/self-injection
may result in severe pain and swelling, particularly if injected into a joint or finger, and in
rare cases could result in the loss of the affected finger if prompt medical attention is
not given. If you are accidentally injected with this veterinary medicinal product, seek
prompt medical advice even if only a very small amount is injected and take the
package leaflet with you. If pain persists for more than 12 hours after medical
examination, seek medical advice again.
To the physician:
This veterinary medicinal product contains mineral oil. Even if small amounts have been
injected, accidental injection with this veterinary medicinal product can cause intense
swelling, which may, for example, result in ischaemic necrosis and even the loss of a
digit. Expert, PROMPT, surgical attention is required and may necessitate early incision
and irrigation of the injected area, especially where there is involvement of finger pulp
or tendon.
Special precautions for the protection of the environment:
Not applicable.

No information is available on the safety and efficacy of this vaccine when used with
any other veterinary medicinal product. A decision to use this vaccine before or after
any other veterinary medicinal product therefore needs to be made on a case by case
basis.

Store and transport refrigerated (2 ºC – 8 ºC).
Do not freeze.
Protect from light.

Zero days.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.