POM-V Prescription Required Companion Animal

Clavusan 250 mg + 62.5 mg Tablets for Dogs and Cats

Active ingredients: Amoxicillin Trihydrate, Potassium Clavulanate

Form

Tablet

Species

Cats Dogs

Manufacturer

Alfasan Nederland B.V.

VMD MA No.

36408/3041

What it's used for

tract infections; respiratory disease (involving upper and lower respiratory tract); enteritis.

Full indications, dosage and side effects ↓

View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for Amoxicillin Trihydrate + Pot...

1

Ask your vet for a written prescription

They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

Fill it at a registered online retailer

The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

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Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Clavusan 250 mg + 62.5 mg Tablets for Dogs and Cats — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

tract infections; respiratory disease (involving upper and lower respiratory tract);
enteritis.

The recommended dose is 12.5 mg/kg body weight (10 mg amoxicillin/2.5 mg
clavulanic acid per kg body weight), twice daily.
The following table is intended as a guide to dispensing the tablets at the
recommended dose.
To ensure a correct dosage body weight should be determined as accurately as
possible to avoid underdosing.
Number of tablets twice daily
(dosage rate: 12.5 mg/kg b.w.)
Body
weight
(kg)
Amoxicillin/clavulanic
acid
50 mg + 12.5 mg
Amoxicillin/clavulanic
acid
250 mg + 62.5 mg
Amoxicillin/clavulanic
acid
500 mg + 125 mg
1-1.25¼-->1.25-2.5½-->2.5-3.75¾-->3.75-51-->5-6.251 ¼¼->6.25-12.5-½¼>12.5-18.75-¾->18.75-25-1½>25-31.25-1 ¼->31.25-37.5-1 ½->37.5-50--1>50-62.5--1 ¼>62.5-75--1 ½
= ¼ tablet = ½ tablet = ¾ tablet = 1 tablet
Tablets can be divided into 2 or 4 equal parts to ensure accurate dosage.
The minimum treatment duration is 5 days with the majority of routine cases
responding after between 5 and 7 days therapy.
In chronic or refractory cases, a longer course of therapy may be required e.g. chronic
skin disease 10 – 20 days, chronic cystitis 10 – 28 days, respiratory disease 8 – 10
days.
In such circumstances overall treatment length is at the clinician's discretion, but
should be long enough to ensure complete resolution of the bacterial disease.

Do not use in rabbits, guinea pigs, hamsters, gerbils or chinchillas.
Do not use in known cases of hypersensitivity to the active substances, to other
antimicrobials of the β-lactam group or to any of the excipients.
Do not use in animals with serious dysfunction of the kidneys accompanied by anuria
and oliguria.
Do not use in ruminants and horses.

Dogs and cats:
Very rare
(<1 animal / 10,000 animals treated,
including isolated reports):
Gastrointestinal disorders (vomiting, diarrhoea,
anorexia).
Undetermined frequency (cannot be
estimated from the available data)
Allergic reactions (skin reactions, anaphylaxis)*.
* In these cases, administration should be discontinued and a symptomatic treatment
given.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See also section “Contact
Details” of the package leaflet for respective contact details.

Cross-resistance has been shown between amoxicillin/clavulanic acid and
antibiotics. Use of the product should be carefully considered when susceptibility
testing has shown resistance to antibiotics because its effectiveness may be
reduced.

Special precautions for safe use in the target species:
Use of the product should be based on identification and susceptibility testing of the
target pathogen(s). If this is not possible, therapy should be based on epidemiological
information and knowledge of susceptibility of the target pathogens at local/regional
level. Use of the product should be in accordance with official, national and regional
antimicrobial policies.
An antibiotic with a lower risk of antimicrobial resistance selection (lower AMEG
category) should be used for first line treatment where susceptibility testing suggests
the likely efficacy of this approach. Narrow spectrum antibiotic therapy with a lower risk
of antimicrobial resistance selection should be used for first line treatment where
susceptibility testing suggests the likely efficacy of this approach.
Caution is advised when using the product in small herbivores, other than those
which have been contraindicated in section 3.3.
In animals with hepatic and renal dysfunction, the dosing regimen should be carefully
evaluated.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection,
inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead to cross-
reaction to cephalosporins and
occasionally be serious.
Do not handle this product if you know you are sensitised, or if you have been advised
not to work with such preparations.
Handle this product with great care to avoid exposure, taking all recommended
precautions.
If you develop symptoms following exposure such as a skin rash, you should seek
medical advice and show the doctor this warning. Swelling of the face, lips or eyes or
difficulty with breathing, are more serious symptoms and require urgent medical
attention.
Wash hands after use.
To avoid accidental ingestion, particularly by a child, unused part-tablets should be
returned to the open blister space, inserted back into the outer packaging and kept in
a safe place out of the sight and reach of children.
Special precautions for the protection of the environment:
Not applicable.

Chloramphenicol, macrolides, sulfonamides and tetracyclines may inhibit the
antibacterial effect of penicillins because of the rapid onset of bacteriostatic action.
Consider potential cross allergies with other penicillins. Penicillins can increase the
effect of aminoglycosides.

Do not store above 30ºC.
Store in the original package.

Not applicable.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.