Bravecto Plus 500 mg / 25 mg Spot-on Solution for Large Cats (>6.25 – 12.5 kg)

Ticks and fleas need to start feeding on the host to become exposed to fluralaner;
therefore, the risk of the transmission of parasite borne diseases cannot be excluded.
Cats in areas endemic for heartworm (or those which have travelled to endemic
areas) may be infected with adult heartworms. No therapeutic effect against adult
Dirofilaria immitis has been established. It is therefore recommended, in accordance
with good veterinary practice, that animals of 6 months of age or older and living in
areas where a vector exists, should be tested for existing adult heartworm infections
before application of the veterinary medicinal product for the prevention of heartworm
disease.
For the prevention of heartworm disease in cats that are only temporarily in endemic
areas, the veterinary medicinal product should be applied before the first expected
exposure to mosquitoes and should be continued at 12-week intervals until return to
a non-endemic area. The period between treatment and return from the endemic
areas should not exceed 60 days.
For the treatment of infections with ear mites (Otodectes cynotis) or the
gastrointestinal nematodes T. cati and A. tubaeforme
frequency of, re-treatment as well as the choice of the treatment (monosubstance or
combination product) should be evaluated by the prescribing veterinarian.
Unnecessary use of antiparasitics or use deviating from the instructions given in the
SPC may increase the resistance selection pressure and lead to reduced efficacy.
The decision to use the veterinary medicinal product should be based on
confirmation of the parasitic species and burden, or of the risk of infestation based on
its epidemiological features, for each individual animal.
Parasite resistance to any particular class of anthelmintic may develop following
frequent, repeated use of an anthelmintic of that class under specific circumstances.
Parasite control is recommended throughout the period of potential infestation risk.
The possibility that other animals in the same household can be a source of re-
infection with fleas, ear mites or gastrointestinal nematodes should be considered,

Revised: September 2023
AN: 01530/2022
and these should be treated as necessary with an appropriate veterinary medicinal
product.
Avoid frequent swimming or shampooing the animal because the maintenance of
effectiveness of the product in these cases has not been tested.
No therapeutic effect against adult A. abstrusus has been established. For the
treatment of pre-existing infections with adult . abstrusus, administration of a
product authorised for treatment of adult A. abstrusus is required.

Special precautions for use in animals
Care should be taken to avoid contact with the eyes of the animal.
Do not use directly on skin lesions.
In the absence of available data, treatment of kittens less than 9 weeks of age and
cats less than 1.2 kg bodyweight is not recommended.
Treatment of male breeding animals is not recommended.
This veterinary medicinal product is for topical use and should not be administered
orally.
Oral uptake of the veterinary medicinal product at the maximum recommended dose
of 93 mg fluralaner + 4.65 mg moxidectin/kg body weight induced some self-limiting
salivation or single incidences of vomiting immediately after administration.
It is important to apply the dose as indicated to prevent the animal from licking and
ingesting the veterinary medicinal product (see sections