POM-V
Prescription Required
Companion Animal
Baytril 25 mg/ml Solution for Injection
Active ingredient: Enrofloxacin
Form
Injection
Species
Cats
Dogs
Ornamental Birds
Pigs
Rabbits
Reptiles
Rodents
Manufacturer
Elanco GmbH
VMD MA No.
52127/5119
What it's used for
Dogs Treatment of infections of the alimentary, respiratory and urogenital tracts (including prostatitis, adjunctive antibiotic therapy for pyometra), skin...
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Clinical information
Baytril 25 mg/ml Solution for Injection — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 18 Mar 2026.
Dogs
Treatment of infections of the alimentary, respiratory and urogenital tracts
(including prostatitis, adjunctive antibiotic therapy for pyometra), skin and
wound infections, otitis (externa/media) caused by enrofloxacin susceptible
strains of: ., Escherichia coli, Pasteurella ., Klebsiella
spp., Bordetella spp., Pseudomonas spp. and Proteus spp.
Cats
Treatment of infections of the alimentary, respiratory and urogenital tracts (as
adjunctive antibiotic therapy for pyometra), skin and wound infections, caused
by enrofloxacin susceptible strains of: ., Escherichia coli,
Pasteurella ., Klebsiella ., Bordetella ., Pseudomonas .
Proteus spp.
Pigs (piglets)
Treatment of infections of the respiratory tract caused by enrofloxacin
susceptible strains of: ., Actinobacillus
Revised: September 2025
AN: 01467/2025
pleuropneumoniae
Treatment of infections of the alimentary tract caused by enrofloxacin
susceptible strains of Escherichia coli.
Treatment of septicaemia caused by enrofloxacin susceptible strains of
Escherichia coli
Rabbits
Treatment of infections of the alimentary and respiratory tracts caused by
enrofloxacin susceptible strains of: ,
Staphylococcus spp.
Treatment of skin and wound infections caused by enrofloxacin susceptible
strains of Staphylococcus aureus.
Rodents, reptiles and ornamental birds
Treatment of infections of the alimentary and respiratory tracts where clinical
experience, if possible, supported by susceptibility testing of the causal
organism, indicates enrofloxacin as the substance of choice.
Treatment of infections of the alimentary, respiratory and urogenital tracts
(including prostatitis, adjunctive antibiotic therapy for pyometra), skin and
wound infections, otitis (externa/media) caused by enrofloxacin susceptible
strains of: ., Escherichia coli, Pasteurella ., Klebsiella
spp., Bordetella spp., Pseudomonas spp. and Proteus spp.
Cats
Treatment of infections of the alimentary, respiratory and urogenital tracts (as
adjunctive antibiotic therapy for pyometra), skin and wound infections, caused
by enrofloxacin susceptible strains of: ., Escherichia coli,
Pasteurella ., Klebsiella ., Bordetella ., Pseudomonas .
Proteus spp.
Pigs (piglets)
Treatment of infections of the respiratory tract caused by enrofloxacin
susceptible strains of: ., Actinobacillus
Revised: September 2025
AN: 01467/2025
pleuropneumoniae
Treatment of infections of the alimentary tract caused by enrofloxacin
susceptible strains of Escherichia coli.
Treatment of septicaemia caused by enrofloxacin susceptible strains of
Escherichia coli
Rabbits
Treatment of infections of the alimentary and respiratory tracts caused by
enrofloxacin susceptible strains of: ,
Staphylococcus spp.
Treatment of skin and wound infections caused by enrofloxacin susceptible
strains of Staphylococcus aureus.
Rodents, reptiles and ornamental birds
Treatment of infections of the alimentary and respiratory tracts where clinical
experience, if possible, supported by susceptibility testing of the causal
organism, indicates enrofloxacin as the substance of choice.
Subcutaneous or intramuscular use.
Repeated injections should be made at different injection sites.
To ensure a correct dosage, body weight (bw) should be determined as
accurately as possible to avoid underdosing.
Dogs and cats
5 mg of enrofloxacin/kg bw, corresponding to 1 ml/5 kg bw, daily by
subcutaneous injection for up to 5 days.
Treatment may be initiated with injectable product and maintained with
enrofloxacin tablets. Duration of treatment should be based on the duration of
treatment approved for the appropriate indication in the product information of
the tablet product.
Pigs (piglets)
2.5 mg of enrofloxacin/kg bw, corresponding to 1 ml/10 kg bw, once daily by
intramuscular injection for 3 days.
Alimentary tract infection or septicaemia caused by : 5 mg of
enrofloxacin/kg of bw, corresponding to 2 ml/10 kg bw, once daily by
intramuscular injection for 3 days.
Revised: September 2025
AN: 01467/2025
In pigs, the injection should be made in the neck at the ear base.
Not more than 3 ml should be administered at one intramuscular injection site.
Rabbits
10 mg/kg bw, corresponding to 2 ml/5 kg bw, once daily by subcutaneous
injection for 5 to 10 consecutive days.
Rodents
10 mg/kg bw, corresponding to 0.4 ml/kg bw, once daily by subcutaneous
injection for 5 to 10 consecutive days. If necessary, depending on the severity
of clinical signs, this dosage can be doubled.
Reptiles
Reptiles are ectothermic, relying on external heat sources to maintain their
body temperature at the optimum level for correct function of all body systems.
Metabolism of substances and activity of the immune system are, thus, critically
dependent on the body temperature. Therefore, the veterinarian must be aware
of the correct temperature requirements of the respective reptile species and
the hydration status of the individual patient. Furthermore, it has to be
considered that large differences exist in the pharmacokinetic behaviour of
enrofloxacin among different species, which additionally will influence the
decision about the correct dosage of
nationally)”
starting point for individual dose setting.
5–10 mg/kg bw, corresponding to 0.2–0.4 ml/kg bw, once daily by intramuscular
injection for 5 consecutive days.
An extension of the treatment interval to 48 hours may be necessary in
individual cases. In complicated infections, higher dosages and longer
treatment courses may be necessary. The presence of the renal portal system
in reptiles means it is prudent to administer substances in the front half of the
body wherever possible.
Ornamental birds
20 mg/kg bw, corresponding to 0.8 ml/kg bw,
injection for 5 to 10 consecutive days. In case of complicated infections higher
doses may be necessary.
Repeated injections should be made at different injection sites.
To ensure a correct dosage, body weight (bw) should be determined as
accurately as possible to avoid underdosing.
Dogs and cats
5 mg of enrofloxacin/kg bw, corresponding to 1 ml/5 kg bw, daily by
subcutaneous injection for up to 5 days.
Treatment may be initiated with injectable product and maintained with
enrofloxacin tablets. Duration of treatment should be based on the duration of
treatment approved for the appropriate indication in the product information of
the tablet product.
Pigs (piglets)
2.5 mg of enrofloxacin/kg bw, corresponding to 1 ml/10 kg bw, once daily by
intramuscular injection for 3 days.
Alimentary tract infection or septicaemia caused by : 5 mg of
enrofloxacin/kg of bw, corresponding to 2 ml/10 kg bw, once daily by
intramuscular injection for 3 days.
Revised: September 2025
AN: 01467/2025
In pigs, the injection should be made in the neck at the ear base.
Not more than 3 ml should be administered at one intramuscular injection site.
Rabbits
10 mg/kg bw, corresponding to 2 ml/5 kg bw, once daily by subcutaneous
injection for 5 to 10 consecutive days.
Rodents
10 mg/kg bw, corresponding to 0.4 ml/kg bw, once daily by subcutaneous
injection for 5 to 10 consecutive days. If necessary, depending on the severity
of clinical signs, this dosage can be doubled.
Reptiles
Reptiles are ectothermic, relying on external heat sources to maintain their
body temperature at the optimum level for correct function of all body systems.
Metabolism of substances and activity of the immune system are, thus, critically
dependent on the body temperature. Therefore, the veterinarian must be aware
of the correct temperature requirements of the respective reptile species and
the hydration status of the individual patient. Furthermore, it has to be
considered that large differences exist in the pharmacokinetic behaviour of
enrofloxacin among different species, which additionally will influence the
decision about the correct dosage of
nationally)”
starting point for individual dose setting.
5–10 mg/kg bw, corresponding to 0.2–0.4 ml/kg bw, once daily by intramuscular
injection for 5 consecutive days.
An extension of the treatment interval to 48 hours may be necessary in
individual cases. In complicated infections, higher dosages and longer
treatment courses may be necessary. The presence of the renal portal system
in reptiles means it is prudent to administer substances in the front half of the
body wherever possible.
Ornamental birds
20 mg/kg bw, corresponding to 0.8 ml/kg bw,
injection for 5 to 10 consecutive days. In case of complicated infections higher
doses may be necessary.
Do not use in the case of known hypersensitivity to fluoroquinolones or to any
of the excipients.
Do not use in animals that are epileptic or suffer from seizures since
enrofloxacin may cause CNS stimulation.
Do not use in young dogs during their growth, i.e. in small breeds of dogs less
than 8 months of age, in big breeds of dogs less than 12 months of age, in giant
breeds of dogs less than 18 months of age.
Do not use in cats less than 8 weeks of age.
of the excipients.
Do not use in animals that are epileptic or suffer from seizures since
enrofloxacin may cause CNS stimulation.
Do not use in young dogs during their growth, i.e. in small breeds of dogs less
than 8 months of age, in big breeds of dogs less than 12 months of age, in giant
breeds of dogs less than 18 months of age.
Do not use in cats less than 8 weeks of age.
Digestive tract disorders (e.g. diarrhoea
very rare cases. These signs are generally mild and transient.
In very rare cases, neurological signs (seizures, tremors, ataxia, excitation) and
anaphylactic reactions can also occur.
Local reactions at injection site
In pigs, after intramuscular administration of the product, inflammatory reactions
may occur. They may persist up to 28 days after the injection.
In dogs, a moderate and transient local reaction (such as oedema) may occur.
In rabbits, reactions (from reddening to ulcerative lesions with deep loss of
tissue), may occur. They may persist at least up to 17 days after the injection.
In reptiles and birds, muscle bruising may occur in very rare cases.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals displaying adverse reactions during
the course of one treatment)
- common (more than 1 but less than 10 animals in 100 animals)
- uncommon (more than 1 but less than 10 animals in 1,000 animals)
- rare (more than 1 but less than 10 animals in 10,000 animals)
- very rare (less than 1 animal in 10,000 animals, including isolated reports).
Revised: September 2025
AN: 01467/2025
very rare cases. These signs are generally mild and transient.
In very rare cases, neurological signs (seizures, tremors, ataxia, excitation) and
anaphylactic reactions can also occur.
Local reactions at injection site
In pigs, after intramuscular administration of the product, inflammatory reactions
may occur. They may persist up to 28 days after the injection.
In dogs, a moderate and transient local reaction (such as oedema) may occur.
In rabbits, reactions (from reddening to ulcerative lesions with deep loss of
tissue), may occur. They may persist at least up to 17 days after the injection.
In reptiles and birds, muscle bruising may occur in very rare cases.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals displaying adverse reactions during
the course of one treatment)
- common (more than 1 but less than 10 animals in 100 animals)
- uncommon (more than 1 but less than 10 animals in 1,000 animals)
- rare (more than 1 but less than 10 animals in 10,000 animals)
- very rare (less than 1 animal in 10,000 animals, including isolated reports).
Revised: September 2025
AN: 01467/2025
None.
i) Special precautions for use in animals
Official and local antimicrobial policies should be taken into account when the
product is used.
Fluoroquinolones should be reserved for the treatment of clinical conditions
which have responded poorly, or are expected to respond poorly, to other
classes of antimicrobials.
Whenever possible fluoroquinolones should only be used based on
susceptibility testing.
Use of the product including use deviating from the instructions given in the
SPC may increase the prevalence of bacteria resistant to enrofloxacin and may
decrease the effectiveness of treatment with all fluoroquinolones due to the
potential for cross-resistance.
Revised: September 2025
AN: 01467/2025
Special caution should be taken when using enrofloxacin in animals with
impaired renal function.
Special caution should be taken when using enrofloxacin in cats because
higher doses than recommended can cause retinal damage and blindness (see
section 4.10).
ii) Special precautions to be taken by the person administering the veterinary
medicinal product to animals
Enrofloxacin may cause hypersensitivity (allergic reactions). People with known
hypersensitivity to fluoroquinolones (e.g., enrofloxacin or ciprofloxacin) should
avoid any contact with the product.
The product may be irritant to skin and eyes. In case of contact with skin or eyes,
wash the affected area with clear running water.
Wash hands after use. Do not eat, drink or smoke whilst handling the product.
Care should be taken to avoid accidental self-injection. If accidental self-
injection occurs seek medical advice immediately.
iii) Other precautions
In countries where feeding of fallen stock to scavenger bird populations is
permitted as a conservation measure (see Commission Decision
2003/322/EC), the possible risk to hatching success should be considered
before feeding carcasses of livestock recently treated with this product.
i) Special precautions for use in animals
Official and local antimicrobial policies should be taken into account when the
product is used.
Fluoroquinolones should be reserved for the treatment of clinical conditions
which have responded poorly, or are expected to respond poorly, to other
classes of antimicrobials.
Whenever possible fluoroquinolones should only be used based on
susceptibility testing.
Use of the product including use deviating from the instructions given in the
SPC may increase the prevalence of bacteria resistant to enrofloxacin and may
decrease the effectiveness of treatment with all fluoroquinolones due to the
potential for cross-resistance.
Revised: September 2025
AN: 01467/2025
Special caution should be taken when using enrofloxacin in animals with
impaired renal function.
Special caution should be taken when using enrofloxacin in cats because
higher doses than recommended can cause retinal damage and blindness (see
section 4.10).
ii) Special precautions to be taken by the person administering the veterinary
medicinal product to animals
Enrofloxacin may cause hypersensitivity (allergic reactions). People with known
hypersensitivity to fluoroquinolones (e.g., enrofloxacin or ciprofloxacin) should
avoid any contact with the product.
The product may be irritant to skin and eyes. In case of contact with skin or eyes,
wash the affected area with clear running water.
Wash hands after use. Do not eat, drink or smoke whilst handling the product.
Care should be taken to avoid accidental self-injection. If accidental self-
injection occurs seek medical advice immediately.
iii) Other precautions
In countries where feeding of fallen stock to scavenger bird populations is
permitted as a conservation measure (see Commission Decision
2003/322/EC), the possible risk to hatching success should be considered
before feeding carcasses of livestock recently treated with this product.
Do not use enrofloxacin concomitantly with antimicrobial substances acting
antagonistically to quinolones (e.g. macrolides, tetracyclines or phenicols).
Do not use concurrently with theophylline as the elimination of theophylline may
be delayed.
Care should be taken during the concomitant use of flunixin and enrofloxacin in
dogs to avoid adverse drug reactions. The decrease in drug clearances as a
result of co-administration of flunixin and enrofloxacin indicates that these
substances interact during the elimination phase. Thus, in dogs, the co-
administration of enrofloxacin and flunixin increased the AUC and the
elimination half-life of flunixin and increased the elimination half-life and
reduced the Cmax of enrofloxacin.
antagonistically to quinolones (e.g. macrolides, tetracyclines or phenicols).
Do not use concurrently with theophylline as the elimination of theophylline may
be delayed.
Care should be taken during the concomitant use of flunixin and enrofloxacin in
dogs to avoid adverse drug reactions. The decrease in drug clearances as a
result of co-administration of flunixin and enrofloxacin indicates that these
substances interact during the elimination phase. Thus, in dogs, the co-
administration of enrofloxacin and flunixin increased the AUC and the
elimination half-life of flunixin and increased the elimination half-life and
reduced the Cmax of enrofloxacin.
Advice for handling: Do not refrigerate or freeze.
Revised: September 2023
AN: 03529/2022
Revised: September 2023
AN: 03529/2022
Pigs:
Meat and offal: 13 days.
Rabbits:
Meat and offal: 6 days.
Do not use in birds intended for human consumption.
5.
Meat and offal: 13 days.
Rabbits:
Meat and offal: 6 days.
Do not use in birds intended for human consumption.
5.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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