POM-V Prescription Required Companion Animal

Apravet 552 IU/mg Powder for Use in Drinking Water/Milk for Pigs, Calves, Chickens and Rabbits

Active ingredient: Apramycin

Form

Powder

Species

Cattle Chickens Pigs Rabbits

Manufacturer

Huvepharma NV

VMD MA No.

30282/4030

What it's used for

Cattle (pre-ruminant): Treatment of bacterial enteritis caused by Escherichia coli and clinical outbreaks due to subsp. enterica (Salmonella Dublin) suscep...

Full indications, dosage and side effects ↓

View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for Apramycin

1

Ask your vet for a written prescription

They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

Fill it at a registered online retailer

The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

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Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Apravet 552 IU/mg Powder for Use in Drinking Water/Milk for Pigs, Calves, Chickens and Rabbits — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

Cattle (pre-ruminant): Treatment of bacterial enteritis caused by Escherichia coli and
clinical outbreaks due to subsp. enterica
(Salmonella Dublin) susceptible to apramycin. Treatment should be based on prior
confirmation of the Salmonella serovars involved or at least the availability of
epidemiological data confirming the presence of this serovar.
Chickens (broilers): Treatment of colibacillosis caused by Escherichia coli susceptible to
apramycin.
Rabbits: Treatment and metaphylaxis of bacterial enteritis caused by Escherichia coli
susceptible to apramycin. The presence of the disease in the herd must be established
before the veterinary medicinal product is used.

In the case of cattle (pre-ruminant) it can be administered in milk or milk replacer.
Amounts to be administered:
Pigs (weaned piglets):
Administer 12,500 IU apramycin sulfate per kilogram of bodyweight (corresponding to
22.5 mg of veterinary medicinal product/kg bw), daily for 7 consecutive days.
Cattle (pre-ruminant):
Administer 40,000 IU apramycin sulfate per kilogram of bodyweight (corresponding to
72 mg of veterinary medicinal product/kg bw), daily for 5 consecutive days.
Chickens (broilers):
Administer 80,000 IU apramycin sulfate per kilogram of bodyweight (corresponding to
144 mg of veterinary medicinal product/kg bw), daily for 5 consecutive days.
Rabbits:
Administer 20,000 IU apramycin sulfate per kilogram of bodyweight (corresponding to
36 mg of veterinary medicinal product/kg bw), daily for 5 consecutive days.
The intake of medicated water depends on the clinical condition of the animals. In order
to obtain the correct dose, the concentration of the has active substance may need to
be adjusted accordingly.
Based on the recommended dose and the number and weight of animals to be treated,
the exact daily concentration of the veterinary medicinal product should be calculated
according to the following formula:
(mg veterinary
medicinal
product/kg body
weight per day)
X
average body weight
(kg) of animals to be
treated
=
mg veterinary medicinal
product per litre of drinking
water/milk
Average daily water intake (l/animal)
To ensure a correct dosage, bodyweight should be determined as accurately as
possible. Prepare the solution with fresh tap water (or milk/milk replacer for calves)
immediately before use. Medicated drinking water should be refreshed or replaced
every 24 hours. Milk replacer should be prepared prior to the addition of the powder.
AN: 03211/2024 & 03212/2024
The solution should be vigorously stirred for 5 minutes. Medicated milk/milk replacer
should be consumed immediately after preparation Water uptake should be monitored
at frequent intervals during medication. In order to ensure consumption of the
medicated water, animals should not have access to other water supplies whilst being
treated. After the end of the medication period, the water supply system should be
cleaned appropriately to avoid intake of sub-therapeutic amounts of the active
substance. If it is not possible to obtain sufficient uptake of medicated water, animals
should be treated parenterally (where appropriate). The maximum solubility of the
product in water and milk replacer is approximately 1000 g/L. The use of suitably
calibrated measuring equipment is recommended.

Do not use in cases of hypersensitivity to the active substance.
Do not use in cattle (pre-ruminant) with functional rumen.
AN: 03211/2024 & 03212/2024
Do not use in animals suffering from kidney disorders.

None known.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
the marketing authorisation holder. See the package leaflet for contact details.

None.

Special precautions for safe use in the target species:
Use of the veterinary medicinal product should be based on susceptibility testing of the
bacteria isolated from the animal. If this is not possible, therapy should be based on local
(regional, farm level) epidemiological information about susceptibility of the target
bacteria.
Where a diagnosis of Dublin is made on the farm, then control measures
including on-going monitoring of disease status, vaccination, biosecurity and movement
controls should be considered. National control programmes should be followed where
available.
Use of the veterinary medicinal product deviating from the instructions given in the
Summary of Product Characteristics may increase the prevalence of bacteria resistant to
the apramycin and may decrease the effectiveness of treatment with aminoglycosides
due to the potential for cross-resistance.
Official, national and regional antimicrobial policies should be taken into account when
the veterinary medicinal product is used.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
People with known hypersensitivity to apramycin or any other aminoglycoside should
avoid contact with the veterinary medicinal product.
This veterinary medicinal product may cause irritation or sensitisation after skin or eye
contact or inhalation.
Avoid contact with the eyes, skin and mucous membranes and inhalation of dust while
preparing the medicated water/milk.
Use personal protective equipment consisting of gloves, mask, goggles and protective
clothing while handling the veterinary medicinal product.
Wash hands after use.
In case of eye contact, rinse the affected area with plenty of water. In case of skin contact,
wash thoroughly with soap and water. If irritation persists, seek medical advice.
In the case of accidental ingestion, seek medical advice immediately and show the
package leaflet or the label to the physician.
In case of onset of symptoms after exposure such as skin rash, seek medical advice
immediately and show the package leaflet or the label to the physician. Swelling of the
face, lips and eyes or difficult breathing are more serious symptoms and require urgent
medical assistance.
AN: 03211/2024 & 03212/2024
Special precautions for the protection of the environment:
Not applicable.

Store below 25 °C.

Pigs (weaned piglets):
- Meat and offal: Zero days.
Cattle (pre-ruminant):
-Meat and offal: 28 days.
Chickens (broilers):
-Meat and offal: Zero days.
AN: 03211/2024 & 03212/2024
-Not for use in birds producing eggs for human consumption. Do not use within 4
weeks of the start of the laying period.
Rabbits:
-Meat and offal: Zero days.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.