POM-V Prescription Required Companion Animal

Apravet 100 000 IU/g Premix for Medicated Feeding Stuff for Pigs and Rabbits

Active ingredient: Apramycin

Form

Premix

Species

Pigs Rabbits

Manufacturer

Huvepharma NV

VMD MA No.

30282/4026

What it's used for

Rabbits: Reduction in mortality and clinical signs related to epizootic enterocolitis due to Escherichia Coli. The presence of the disease in the group mus...

Full indications, dosage and side effects ↓

View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for Apramycin

1

Ask your vet for a written prescription

They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

Fill it at a registered online retailer

The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Your prescription rights → VMD register of retailers →

Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Apravet 100 000 IU/g Premix for Medicated Feeding Stuff for Pigs and Rabbits — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

Rabbits:
Reduction in mortality and clinical signs related to epizootic enterocolitis due to
Escherichia Coli.
The presence of the disease in the group must be established before the veterinary
medicinal product is used.

Pigs:
The dosage is 4 000-8 000 IU/kg of bodyweight per day (equivalent to 4-8 g of the
veterinary medicinal product per 100kg of bodyweight per day).
Administer as the sole feeding stuff for at least 21 days.
Rabbits:
The dosage is 12 000 IU/kg of bodyweight per day (equivalent to 12 g of the
veterinary medicinal product per 100kg of bodyweight per day) for a period up to 21
days.
To ensure a correct dosage, bodyweight should be determined as accurately as
possible.
For all species, the consumption of the medicated feed may depend of the clinical
condition of the animals. In order to guarantee a correct dosing, the concentration of
the veterinary medicinal product in the feed should be adjusted accordingly.
To adjust dosing properly following calculation can be used:
… g product/kg b.w./day x average b.w. (kg) = … kg of the product/ton of feed
average daily feed intake (kg/animal)
Mixing Instructions:
It is recommended to initially mix the veterinary medicinal product with a small
amount of the feeding stuff (20-50 kg) before incorporating it in the full amount of
feeding stuff.
AN: 02763/2024 & 02764/2024
Medicated feed may be pelleted using a pre-conditioning step for 5 minutes at a
temperature not exceeding 85°C.

Do not use in the cases of hypersensitivity to the active substance, to other
aminoglycosides or to any of the excipients.
Do not use in cats.
AN: 02763/2024 & 02764/2024

None known.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
the marketing authorisation holder or the national competent authority via the
national reporting system. See the package leaflet for respective contact details.
AN: 02763/2024 & 02764/2024

The uptake of medication by animals can be altered as a consequence of illness. In
case of insufficient uptake of feed animals should be treated parenterally.
The use of the veterinary medicinal product should be combined with good
management practices e.g. good hygiene, proper ventilation, no overstocking.

Special precautions for safe use in the target species:
Use of the veterinary medicinal product should be based on susceptibility testing of
the target pathogen(s). If this is not possible, therapy should be based on
epidemiological information and knowledge of susceptibility of the target pathogens
at farm level, or at local/regional level.Use of the veterinary medicinal product
deviating from the instructions given in the SPC may increase the prevalence of
bacteria resistant to the apramycin and may decrease the effectiveness of treatment
with aminoglycosides due to the potential for cross-resistance.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
People with known hypersensitivity to apramycin or any other aminoglycoside should
avoid contact with the veterinary medicinal product.
This veterinary medicinal product may cause irritation after skin or eye contact or
inhalation. During preparation and administration of the medicated feedingstuff, skin,
eye and oral contact with the veterinary medicinal product, as well as inhalation of
dust, should be avoided. Wear a protective suit, gloves and an appropriate dust mask
(either a disposable half mask respirator conforming to European Standard EN149 or
a non-disposable respirator conforming to European Standard EN140 with a filter to
EN 143) when mixing and handling the veterinary medicinal product.
In the event of eye contact, rinse the affected area with plenty of water. In the event
of skin contact, wash thoroughly with soap and water. If irritation persists, seek
medical advice. Wash hands after use. In the event of accidental ingestion, seek
medical assistance immediately and show the package label to the physician. In case
of onset of symptoms after exposure such as skin rash, seek medical advice
immediately and show the package label to the physician. Swelling of the lips, face
and eyes or difficulty breathing are more serious symptoms and require urgent
medical assistance.

Aminoglycosides may have a negative influence on the kidney function. The
administration of these agents to animals suffering from renal impairment or in
combination with agents that also affect renal function may therefore present a risk of
intoxication.
Do not administer with other aminoglycosides due to their nephrotoxic potential”.
Aminoglycosides may cause neuromuscular blockade. It is therefore recommended
to take such an effect into account when anaesthetising treated animals.
In certain conditions with a high degree of humidity there might be an apparent
interaction with lectins.

Veterinary medicinal product as packaged for sale: Do not store above 25C. Store in
the original bag. Protect from moisture.
Veterinary medicinal product after first opening of the bag: Do not store above 25°C.
Store in the original bag Store in a dry place.
Medicated feed (mashed and pelleted): Do not store above 25°C.

Pigs: meat and offal - 21 days.
Rabbits: meat and offal - 1 day.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.