Alpramil 4 mg/10 mg Film-coated Tablets for Cats Weighing at Least 0.5 kg
Active ingredients: Milbemycin Oxime (A3 and A4), Praziquantel
Form
Tablet
Species
Manufacturer
Alfasan Nederland B.V.
VMD MA No.
36408/5001
What it's used for
Echinococcus multilocularis - Nematodes: Ancylostoma tubaeforme Toxocara cati Prevention of heartworm disease (Dirofilaria immitis) if concomitant treatmen...
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Alpramil 4 mg/10 mg Film-coated Tablets for Cats Weighing at Least 0.5 kg — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.
- Nematodes:
Ancylostoma tubaeforme
Toxocara cati
Prevention of heartworm disease (Dirofilaria immitis) if concomitant treatment against
cestodes is indicated.
possible.
Minimum recommended dose rate: 2 mg of milbemycin oxime and 5 mg of
praziquantel per kg are given orally as a single dose.
The veterinary medicinal product should be administered with or after some food.
Doing so ensures optimum protection against heartworm disease.
Depending on the bodyweight of the cat and the availability of tablet strengths,
practical dosing examples are as follows:
Weight
(kg)
4 mg/10 mg tablet0.5 – 1½ tablet> 1 – 2 1 tablet> 2 – 3
1½ tablets> 3 – 4
2 tablets
The veterinary medicinal product can be inserted into a programme for prevention of
heartworm disease if at the same time treatment against tapeworms is indicated. The
veterinary medicinal product has a duration of heartworm prevention of one month.
For regular prevention of heartworm disease, the use of a monosubstance is
preferred.
Do not use in cases of hypersensitivity to the active substances or to any of the
excipients.
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Hypersensitivity reaction
;
Systemic disorders (e.g. lethargy)
;
Neurological disorders (e.g. muscle tremor and
ataxia)
;
Digestive tract disorders (e.g. emesis and
diarrhoea)
.
Especially in young cats.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.
information and the risk of exposure of the cat should be taken into account.
It is recommended to treat all the animals living in the same household
concomitantly.
When infection with the cestode D. caninum has been confirmed, concomitant
treatment against intermediate hosts, such as fleas and lice, should be discussed
with a veterinarian to prevent re-infection.
Parasite resistance to any particular class of anthelmintic may develop following
frequent, repeated use of an anthelmintic of that class. Unnecessary use of
antiparasitics or use deviating from the instructions may increase the resistance
selection pressure and lead to reduced efficacy.
Special precautions for safe use in the target species:
No studies have been performed with severely debilitated cats or individuals with
seriously compromised kidney or liver function. The veterinary medicinal product is
not recommended for such animals or only according to a benefit/risk assessment by
the responsible veterinarian.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
This veterinary medicinal product may be harmful when ingested, particularly for
children.
Avoid accidental ingestion.
AN: 02391/2025 & 02646/2025
Any unused tablet parts should be discarded or returned to the open blister, inserted
back into the outer packaging and used at the next administration. The veterinary
medicinal product should be stored in a safe place.
In case of accidental ingestion, seek medical advice immediately and show the
package leaflet or the label to the physician.
Wash hands after use.
Special precautions for the protection of the environment:
Not applicable.
Other precautions:
Echinococcosis represents a hazard for humans. As Echinococcosis is a notifiable
disease to the World Organisation for Animal Health (WOAH), specific guidelines on
the treatment and follow-up and on the safeguard of persons need to be obtained
from the relevant competent authority.
tolerated. No interactions were observed when the recommended dose of the
macrocyclic lactone selamectin was administered during treatment with the veterinary
medicinal product at the recommended dose.
AN: 02391/2025 & 02646/2025
Although not recommended, the concomitant use of the veterinary medicinal product
with a spot on containing moxidectin and imidacloprid at recommended dose rates
following a single application was well tolerated in one laboratory study in 10 kittens.
The safety and efficacy of the concurrent use have not been investigated in field
studies. In the absence of further studies, caution should be taken in the case of
concurrent use of the veterinary medicinal product with any other macrocyclic
lactone. Also, no such studies have been performed with reproducing animals.
4.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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Related Conditions
Other Products Containing Milbemycin Oxime (A3 and A4)
These products share the same active ingredient and may be suitable alternatives. Always consult your vet.
Aderexa 12.5 mg/125 mg Chewable Tablets for Dogs Weighing at Least 5 kg
POM-VKRKA, d.d., Novo mesto
Aderexa 2.5 mg/25 mg Chewable Tablets for Small Dogs and Puppies Weighing at Least 0.5 kg
POM-VKRKA, d.d., Novo mesto
Alpramil 12 mg/30 mg Film-coated Tablets for Cats Weighing at Least 3 kg
POM-VAlfasan Nederland B.V.
Alpramil 12 mg/30 mg Film-coated Tablets for Cats Weighing at Least 3 kg
POM-VAlfasan Nederland B.V.
Alpramil 12.5 mg/125 mg Tablets for Dogs Weighing at Least 5 kg
POM-VAlfasan Nederland B.V.
Alpramil 12.5 mg/125 mg Tablets for Dogs Weighing at Least 5 kg
POM-VAlfasan Nederland B.V.
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