Advocate Spot-on Solution for Large Dogs

The product’s efficacy has not been tested in ferrets weighing over 2 kg and
therefore the duration of effect might be shorter in these animals.
Brief contact of the animal with water on one or two occasions between monthly
treatments is unlikely to significantly reduce the efficacy of the product. However,
frequent shampooing or immersion of the animal in water after treatment may
reduce the efficacy of the product.
Parasite resistance to any particular class of anthelmintic may develop following
frequent, repeated use of an anthelmintic of that class. Therefore, the use of this
product should be based on the assessment of each individual case and on local
epidemiological information about the current susceptibility of the target species in
order to limit the possibility of a future selection for resistance.
The use of the product should be based on the confirmed diagnosis of mixed
infection (or risk of infection, where prevention applies) at the same time (see also
sections 4.2 and 4.9).

Revised: December 2025
MA split from NI Expiry following AN: 02105/2025
4.5
i) Special precautions for use in animals
The treatment of cats weighing less than 1 kg and ferrets weighing less than 0.8 kg
should be based on a benefit-risk assessment.
There is limited experience on the use of the product in sick and debilitated animals,
thus the product should only be used based on a benefit-risk assessment for these
animals.
Do not apply in the mouth, in the eyes or the ears of the animal.
Care should be taken that the product is not ingested by animals and does not come
into contact with the eyes or mouth of the recipient and/or other animals.
Consider carefully the correct application method described in section 4.9,
especially that the product should be applied at the base of the skull in order to
minimise the risk for the animal to lick the product.
Do not allow recently treated animals to groom each other. Do not allow treated
animals to come into contact with untreated animals until the application site is dry.
It is recommended that cats and ferrets living in, or travelling to areas endemic for
heartworm are treated monthly with the product to protect them from heartworm
disease.
Whilst the accuracy of diagnosis of heartworm infection is limited, it is recommended
that attempts be made to check the heartworm status of any cat and ferret aged
over 6 months, before beginning prophylactic treatment, as use of the product on
cats or ferrets which have adult heartworms may cause serious adverse effects,
including death. If adult heartworm infection is diagnosed, the infection should be
treated in accordance with current scientific knowledge.
In certain individual cats
cases concomitant supportive treatment is necessary as treatment with the product
alone may not be sufficient to prevent death of the animal.
The safety of the product has not been established in cats with severe clinical
signs of . Use of the product in such cases should be based on the
benefit-risk assessment of the veterinarian.
Imidacloprid is toxic for birds, especially canaries.
ii) Special precautions to be taken by the person administering the veterinary
medicinal product to animals
Avoid contact with skin, eyes or mouth.
Do not eat, drink or smoke during application.

Revised: December 2025
MA split from NI Expiry following AN: 02105/2025
In order to prevent children getting access to pipettes, keep the pipette in the
original packaging until ready for use and dispose of used pipettes immediately.
Wash hands thoroughly after use.
After application do not stroke or groom animals until the application site is dry.
This may be ensured by treating animals in the evening. Do not allow recently
treated animals to sleep with owners, especially children.
In case of accidental spillage onto skin, wash off immediately with soap and water.
People with known hypersensitivity to benzyl alcohol, imidacloprid or moxidectin
should administer the product with caution. In very rare cases the product may
cause skin sensitisation or transient skin reactions (for example numbness,
irritation or burning/tingling sensation).
In very rare cases the product may cause respiratory irritation in sensitive
individuals. If the product accidentally gets into eyes, they should be thoroughly
flushed with water. If skin or eye symptoms persist or if the product is accidentally
swallowed, seek medical advice immediately and show the package leaflet or the
label to the physician.
iii) Other precautions
The solvent in the product may stain or damage certain materials including leather,
fabrics, plastics and finished surfaces. Allow the application site to dry before
permitting contact with such materials.
4.6
Use of the product may result in transient pruritus in cats. On rare occasions greasy
fur, erythema and vomiting can occur. These signs disappear without further
treatment. The product may, in rare cases, cause local hypersensitivity reactions. If
the animal licks the application site after treatment, neurological signs (most of
which are transient) may be observed in very rare cases (see section 4.10).
The product tastes bitter. Salivation may occasionally occur if the animal licks the
application site immediately after treatment. This is not a sign of intoxication and
disappears within some minutes without treatment. Correct application will minimise
licking of the application site.
The product may in very rare cases cause at the application site a sensation
resulting in transient behavioural changes such as lethargy, agitation, and
inappetence.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated
reports).

Revised: December 2025
MA split from NI Expiry following AN: 02105/2025
4.7
The safety of the veterinary medicinal product has not been established during
pregnancy and lactation in the target species. Therefore, the use of the product is
not recommended in animals intended for breeding or during pregnancy and
lactation.
4.8
During treatment with this veterinary medicinal product no other antiparasitic
macrocyclic lactone should be administered.
No interactions between this veterinary medicinal product and routinely used
veterinary medicinal products or medical or surgical procedures have been
observed.
4.9
Dosage schedule for cats:
The recommended minimum doses are 10 mg/kg bodyweight imidacloprid and 1.0
mg/kg bodyweight moxidectin, equivalent to 0.1 ml of this product per kg
bodyweight.
The treatment schedule should be based on individual veterinary diagnosis and on
the local epidemiological situation.
Weight of cat
[kg]
Pipette size to be
used
Volume
[ml]
Imidacloprid
[mg/kg bw]
Moxidect
in [mg/kg
bw]
￿ 4 kgEndectrid for small
cats and ferrets
0.4minimum of
minimum of 1Cats weighing over 4 kg bodyweight: use Endectrid spot-on solution for large cats
Flea treatment and prevention (Ctenocephalides felis)
One treatment prevents future flea infestation for 4 weeks. Existing pupae in the
environment may emerge for 6 weeks or longer after treatment is initiated,
depending upon climatic conditions. Therefore, it may be necessary to combine the
treatment with this product with environmental treatments aimed at breaking the flea
life cycle in the surroundings. This can result in a more rapid reduction in the
household flea population. The product should be administered at monthly intervals
when used as part of a treatment strategy for flea allergy dermatitis.

Revised: December 2025
MA split from NI Expiry following AN: 02105/2025
Treatment of ear mite infestation (Otodectes cynotis)
A single dose of the product should be administered. A further veterinary
examination 30 days after treatment is recommended as some animals may require
a second treatment. Do not apply directly to the ear canal.
Treatment of notoedric mange (Notoedres cati)
A single dose of the product should be administered.
Treatment of the lungworm Eucoleus aerophilus (syn. Capillaria aerophila) (adults)
A single dose of the product should be administered.
Prevention of Aelurostrongylus abstrusus
The product should be administered monthly.
Treatment of Aelurostrongylus abstrusus
The product should be administered monthly for three consecutive months.
Treatment of Troglostrongylus brevior (adults)
Advocate should be administered monthly for two consecutive months.
Treatment of the eye worm Thelazia callipaeda (adults)
A single dose of the product should be administered.
Heartworm prevention (Dirofilaria immitis)
Cats in areas endemic for heartworm, or those which have travelled to endemic
areas, may be infected with adult heartworms. Therefore prior to treatment with this
product, the advice provided in section 4.5 should be considered.
For prevention of heartworm disease, the product must be applied at regular
monthly intervals during the time of the year when mosquitoes (the intermediate
hosts which carry and transmit heartworm larvae) are present. The product may be
administered throughout the year or at least 1 month before the first expected
exposure to mosquitoes. Treatment should continue at regular monthly intervals
until 1 month after the last exposure to mosquitoes. To establish a treatment routine,
it is recommended that the same day or date be used each month. When replacing
another heartworm preventative product in a heartworm prevention programme, the
first treatment with this product must be given within 1 month of the last dose of the
former medication.
In non-endemic areas there should be no risk of cats having heartworm. Therefore,
they can be treated without special precautions.

Revised: December

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