Advantix 600 mg + 3000 mg Spot-on Solution for Dogs (> 40 kg ≤ 60 kg)

It is recommended to apply the treatment at least three days before expected
exposure to Ehrlichia. canis. With regard to E. canis, studies have demonstrated a
reduced risk of canine ehrlichiosis in dogs exposed to Rhipicephalus sanguineus
ticks infected with E. canis from three days following application of the veterinary
medicinal product and to persist for four weeks.
Immediate protection against sandflies bites is not documented. Treated dogs for the
reduction of the risk of infection with Leishmania infantum via transmission by
sandflies Phlebotomus. perniciosus
the first 24 hours after the initial treatment application.
To reduce re-infestation from emergence of new fleas, it is recommended to treat all
dogs in a household. Other animals living in the same household should also be
treated with a suitable product. To aid further in reducing environmental challenge,
the additional use of a suitable environmental treatment against adult fleas and their
developmental stages is recommended.
The veterinary medicinal product remains effective if the animal becomes wet.
However, prolonged, intense exposure to water should be avoided. In cases of
frequent water exposure the persistent efficacy may be reduced. In these cases do
not retreat more frequently than once weekly. If a dog requires a shampoo, it should
be administered before applying the veterinary medicinal product or at least 2 weeks
after application, to optimise efficacy of the veterinary medicinal product.
The possibility that other animals in the same household can be a source of re-
infection with fleas, biting lice, ticks, mosquitoes and flies should be considered, and
these should be treated as necessary with an appropriate product.
In the absence of risk of co-infection, a narrow spectrum veterinary product should be
used. The use of this veterinary medicinal product should take into account local
information about susceptibility of the target parasites, where available.
Unnecessary use of antiparasitics or use deviating from the instructions given in the
SPC may increase the resistance selection pressure and lead to reduced efficacy.
The decision to use the product should be based on confirmation of the parasitic
species and burden, or of the risk of infestation based on its epidemiological features,
for each individual animal.
In Europe, resistance to pyrethroids has been reported in isolated cases of
Rhipicephalus sanguineusStomoxys calcitrans. Current knowledge suggests
that resistance in both parasites is conferred by gene mutations at the target site
while other factors like metabolic detoxification may also play a role.

Special precautions for safe use in the target species:
Care should be taken to avoid the content of the pipette coming into contact with the
eyes or mouth of the recipient dogs.
Care should be taken to administer the veterinary medicinal product correctly as
described under section 3.9. In particular oral uptake due to the licking of the
application site by treated or in contact animals should be avoided.
Do not use on cats.
This veterinary medicinal product is extremely poisonous to cats and could be fatal
due to the unique physiology of cats which is unable to metabolise certain
compounds including permethrin. To prevent cats from being accidentally exposed to
the veterinary medicinal product, keep treated dogs away from cats after treatment
until the application site is dry. It is important to ensure that cats do not groom the site
of application on a dog, which has been treated with this veterinary medicinal
product. Seek veterinary advice immediately if this occurs.
Consult your veterinary surgeon before using the veterinary medicinal product on sick
and debilitated dogs.
Ticks will be killed and fall off the host within 24 to 48 hours after infestation without
having a blood meal, as a rule. An attachment of single ticks after treatment cannot
be excluded. For this reason, a transmission of infectious diseases by ticks cannot be
completely excluded if conditions are unfavourable.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Avoid contact between the veterinary medicinal product and skin, eyes or mouth.
Do not eat, drink or smoke during application.
Wash hands thoroughly after use.
In case of accidental spillage onto skin, wash off immediately with soap and water.
People with known skin sensitivity may be particularly sensitive to this product.
People with known hypersensitivity to imidacloprid and permethrin should administer
the veterinary medicinal product with caution. The predominant clinical symptoms
that in extremely rare case may be shown are transient sensory irritations of the skin
like tingling, burning sensation or numbness.
If the veterinary medicinal product gets accidentally into the eyes, the eyes should be
thoroughly flushed with water.
If skin or if eye irritation persists, seek medical advice immediately and show the
package leaflet or the label to the physician.
Do not ingest. In case of accidental ingestion, seek medical advice immediately and
show the package leaflet or the label to the physician.
Treated dogs should not be handled especially by children until the application site is
dry. This may be ensured by treating the dogs e.g. in the evening. Recently treated
dogs should not be allowed to sleep together with their owner, especially children.
In order to prevent children from getting access to pipettes, keep the pipette in the
original packaging until ready for use and dispose of used pipettes immediately.
Laboratory studies in rabbits and rats with the excipient N-methylpyrrolidone have
shown evidence of foetotoxic effects. The veterinary medicinal product should not be
administered by pregnant women and women suspected of being pregnant. Personal
protective equipment consisting of gloves should be worn when handling the
veterinary medicinal product by women of childbearing age.
Special precautions for the protection of the environment:
As the veterinary medicinal product is dangerous to aquatic organisms, treated dogs
must not under any circumstances be allowed into any type of surface water for at
least 48 hours after treatment.
Other precautions:
The solvent in this veterinary medicinal product may stain certain materials including
leather, fabrics, plastics and finished surfaces. Allow the application site to dry before
permitting contact with such materials.